(40 nodes) DNA damage response, signal transduction by p53 class mediator network (Callithrix jacchus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	PIDD1	P53-induced death domain protein 1. (910 aa)
	TFAP4	Transcription factor AP-4. (338 aa)
	ING4	Inhibitor of growth protein. (249 aa)
	PRAP1	Uncharacterized protein. (220 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
	NDRG1	Uncharacterized protein. (494 aa)
	CHEK2	Uncharacterized protein. (543 aa)
	ATRX	Uncharacterized protein. (2497 aa)
	PPP2R5C	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (555 aa)
	BATF	Basic leucine zipper transcriptional factor ATF-like. (125 aa)
	SESN2	Sestrin-2. (480 aa)
	ENSCJAP00000054712	Uncharacterized protein. (115 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	GML	Glycosylphosphatidylinositol anchored molecule like. (158 aa)
	H9KXQ2_CALJA	Uncharacterized protein. (115 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	E2F7	E2F transcription factor 7. (910 aa)
	SP100	SP100 nuclear antigen. (880 aa)
	TRIAP1	TP53-regulated inhibitor of apoptosis 1. (76 aa)
	BCL3	BCL3 transcription coactivator. (454 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (158 aa)
	CASP2	Caspase-2 isoform 1 preproprotein; Belongs to the peptidase C14A family. (452 aa)
	ENSCJAP00000067777	Uncharacterized protein. (80 aa)
	MUC1	SEA domain-containing protein. (257 aa)
	ENSCJAP00000072280	Uncharacterized protein. (107 aa)
	ENSCJAP00000074699	RRM domain-containing protein. (240 aa)
	MIF	Macrophage migration inhibitory factor. (115 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (556 aa)
	ENSCJAP00000078861	RRM domain-containing protein. (241 aa)
	RPS6KA6	Ribosomal protein S6 kinase. (767 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1262 aa)
	PPM1D	Protein phosphatase, Mg2+/Mn2+ dependent 1D. (605 aa)
	PAXIP1	PAX interacting protein 1. (1053 aa)
	RBM38	RNA-binding protein 38 isoform a. (239 aa)
	FOXM1	Forkhead box M1. (763 aa)
	BRCA2	BRCA2 DNA repair associated. (3409 aa)
	PML	Promyelocytic leukemia. (881 aa)
	MDM4	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
	HIPK2	Homeodomain-interacting protein kinase 2 isoform 1. (1196 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATRX	ENSCJAP00000018844	ENSCJAP00000048346	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.713
ATM	BRCA2	ENSCJAP00000018844	ENSCJAP00000034250	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.966
ATM	CDKN1A	ENSCJAP00000018844	ENSCJAP00000061908	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1.	0.499
ATM	CDKN1B	ENSCJAP00000018844	ENSCJAP00000044442	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1B.	0.407
ATM	CHEK2	ENSCJAP00000018844	ENSCJAP00000046383	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.998
ATM	HIPK2	ENSCJAP00000018844	ENSCJAP00000024462	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Homeodomain-interacting protein kinase 2 isoform 1.	0.529
ATM	KAT5	ENSCJAP00000018844	ENSCJAP00000078212	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.899
ATM	MDM4	ENSCJAP00000018844	ENSCJAP00000031287	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.	0.861
ATM	PAXIP1	ENSCJAP00000018844	ENSCJAP00000000270	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX interacting protein 1.	0.932
ATM	PIDD1	ENSCJAP00000018844	ENSCJAP00000021788	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced death domain protein 1.	0.723
ATM	PPM1D	ENSCJAP00000018844	ENSCJAP00000002144	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein phosphatase, Mg2+/Mn2+ dependent 1D.	0.567
ATM	SP100	ENSCJAP00000018844	ENSCJAP00000058456	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SP100 nuclear antigen.	0.549
ATRX	ATM	ENSCJAP00000048346	ENSCJAP00000018844	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.713
ATRX	BRCA2	ENSCJAP00000048346	ENSCJAP00000034250	Uncharacterized protein.	BRCA2 DNA repair associated.	0.555
ATRX	CHEK2	ENSCJAP00000048346	ENSCJAP00000046383	Uncharacterized protein.	Uncharacterized protein.	0.434
ATRX	PML	ENSCJAP00000048346	ENSCJAP00000033100	Uncharacterized protein.	Promyelocytic leukemia.	0.401
ATRX	SP100	ENSCJAP00000048346	ENSCJAP00000058456	Uncharacterized protein.	SP100 nuclear antigen.	0.877
BCL3	KAT5	ENSCJAP00000059600	ENSCJAP00000078212	BCL3 transcription coactivator.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.410
BRCA2	ATM	ENSCJAP00000034250	ENSCJAP00000018844	BRCA2 DNA repair associated.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.966
BRCA2	ATRX	ENSCJAP00000034250	ENSCJAP00000048346	BRCA2 DNA repair associated.	Uncharacterized protein.	0.555