STRINGSTRING
PRKDC PRKDC TOPAZ1 TOPAZ1 UNC5C UNC5C TEX11 TEX11 SOD1 SOD1 MAEL MAEL SYCP2 SYCP2 DDB1 DDB1 KITLG KITLG BCL2L1 BCL2L1 YBX3 YBX3 KIT KIT ENSCJAP00000056577 ENSCJAP00000056577 SYCE3 SYCE3 BAX BAX CASP2 CASP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4134 aa)
TOPAZ1Protein TOPAZ1; Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear. (1695 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
TEX11Testis expressed 11. (925 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
MAELMaelstrom spermatogenic transposon silencer. (403 aa)
SYCP2Synaptonemal complex protein 2. (1623 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
BCL2L1Bcl-2-like protein 1 isoform 1. (233 aa)
YBX3Y-box binding protein 3. (370 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (976 aa)
ENSCJAP00000056577Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (277 aa)
SYCE3Synaptonemal complex central element protein 3. (88 aa)
BAXBCL2 associated X, apoptosis regulator. (193 aa)
CASP2Caspase-2 isoform 1 preproprotein; Belongs to the peptidase C14A family. (452 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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