(84 nodes) Multicellular organism growth network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AR	Androgen receptor. (887 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (839 aa)
	WWTR1	WW domain-containing protein. (400 aa)
	SPTBN2	Spectrin beta chain; Belongs to the spectrin family. (2394 aa)
	COMP	Cartilage oligomeric matrix protein. (757 aa)
	ETNK2	Ethanolamine kinase 2. (525 aa)
	DUOX2	Dual oxidase 2. (1546 aa)
	ARID5B	AT-rich interaction domain 5B. (1188 aa)
	ERCC1	Uncharacterized protein. (356 aa)
	ATF5	Activating transcription factor 5. (285 aa)
	RBBP6	Uncharacterized protein. (1831 aa)
	TAL2	T-cell acute lymphocytic leukemia protein 2. (108 aa)
	PLEC	Plectin. (6199 aa)
	SLC1A2	Amino acid transporter. (603 aa)
	ZFP36L1	Uncharacterized protein. (338 aa)
	PCDH15	Protocadherin related 15. (1951 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)
	PALB2	Partner and localizer of BRCA2. (1182 aa)
	LOC103787209	Protein NESP55 isoform NESP55. (253 aa)
	PPP1R13L	Protein phosphatase 1 regulatory subunit 13 like. (837 aa)
	ADARB1	Adenosine deaminase RNA specific B1. (789 aa)
	TNS2	Tensin 2. (1491 aa)
	TMED2	Transmembrane emp24 domain-containing protein 2. (208 aa)
	XRCC2	DNA repair protein XRCC2. (280 aa)
	STK40	Serine/threonine-protein kinase 40. (440 aa)
	ENSCJAP00000062412	Kruppel like factor 2. (353 aa)
	CCM2	CCM2 scaffold protein. (444 aa)
	NOTCH2	Notch receptor 2. (2470 aa)
	CLIC4	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
	KDM6A	Lysine demethylase 6A. (1429 aa)
	SLC4A10	Anion exchange protein. (1118 aa)
	STIL	STIL centriolar assembly protein. (1287 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	EN1	Homeobox protein engrailed-like. (391 aa)
	HESX1	Homeobox expressed in ES cells 1. (185 aa)
	ENSCJAP00000053035	Uncharacterized protein. (381 aa)
	CCDC151	Coiled-coil domain containing 151. (594 aa)
	RARG	Retinoic acid receptor gamma isoform 1. (454 aa)
	RASAL2	Ras GTPase-activating protein nGAP isoform 2. (1280 aa)
	TBL1XR1	F-box-like/WD repeat-containing protein TBL1XR1. (514 aa)
	FKBP8	Peptidylprolyl isomerase. (316 aa)
	ATRX	Uncharacterized protein. (2497 aa)
	F7GX44_CALJA	Peptidylprolyl isomerase. (248 aa)
	ATN1	Atrophin 1. (1194 aa)
	WDTC1	WD and tetratricopeptide repeats protein 1 isoform a. (677 aa)
	RMI1	RecQ-mediated genome instability protein 1. (625 aa)
	SLITRK1	SLIT and NTRK like family member 1. (696 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (683 aa)
	RC3H2	RING finger and CCCH-type zinc finger domain-containing protein 2 isoform 1. (1191 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2653 aa)
	CELA1	Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (254 aa)
	TTC8	Tetratricopeptide repeat domain 8. (515 aa)
	SLC12A5	Solute carrier family 12 member 5 isoform 1. (1139 aa)
	PLAG1	PLAG1 zinc finger. (500 aa)
	SLC25A25	Calcium-binding mitochondrial carrier protein SCaMC-2 isoform b; Belongs to the mitochondrial carrier (TC 2.A.29) family. (514 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	FLVCR1	Feline leukemia virus subgroup C receptor-related protein 1. (555 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1333 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	PKDCC	Protein kinase domain-containing protein, cytoplasmic. (493 aa)
	CTC1	CST telomere replication complex component 1. (1217 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (217 aa)
	GIGYF2	PERQ amino acid-rich with GYF domain-containing protein 2 isoform b. (1296 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1490 aa)
	RARA	Uncharacterized protein. (468 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit isoform 1. (760 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
	SELENOM	Sep15_SelM domain-containing protein. (143 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1166 aa)
	HOXA5	Homeobox A5 (Predicted). (270 aa)
	SP2	Sp2 transcription factor. (613 aa)
	WDR11	WD repeat domain 11. (1228 aa)
	HELT	Helt bHLH transcription factor. (242 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	COL3A1	Collagen alpha-1(III) chain preproprotein. (1465 aa)
	EP300	E1A binding protein p300. (2426 aa)
	RARB	Retinoic acid receptor beta isoform 1. (448 aa)
	SLITRK6	SLIT and NTRK like family member 6. (840 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	EP300	ENSCJAP00000006494	ENSCJAP00000008779	Androgen receptor.	E1A binding protein p300.	0.789
AR	KDM6A	ENSCJAP00000006494	ENSCJAP00000060312	Androgen receptor.	Lysine demethylase 6A.	0.405
ATM	ATRX	ENSCJAP00000018844	ENSCJAP00000048346	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.713
ATM	EP300	ENSCJAP00000018844	ENSCJAP00000008779	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E1A binding protein p300.	0.557
ATM	ERCC1	ENSCJAP00000018844	ENSCJAP00000076581	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.756
ATM	ERCC2	ENSCJAP00000018844	ENSCJAP00000023359	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TFIIH basal transcription factor complex helicase XPD subunit isoform 1.	0.835
ATM	ERCC6	ENSCJAP00000018844	ENSCJAP00000024749	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ERCC excision repair 6, chromatin remodeling factor.	0.402
ATM	MTOR	ENSCJAP00000018844	ENSCJAP00000004176	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.640
ATM	PALB2	ENSCJAP00000018844	ENSCJAP00000072948	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Partner and localizer of BRCA2.	0.922
ATM	RMI1	ENSCJAP00000018844	ENSCJAP00000042098	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RecQ-mediated genome instability protein 1.	0.662
ATM	XRCC2	ENSCJAP00000018844	ENSCJAP00000065986	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein XRCC2.	0.726
ATN1	UNC79	ENSCJAP00000047568	ENSCJAP00000034048	Atrophin 1.	Unc-79 homolog, NALCN channel complex subunit.	0.646
ATRX	ATM	ENSCJAP00000048346	ENSCJAP00000018844	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.713
ATRX	RMI1	ENSCJAP00000048346	ENSCJAP00000042098	Uncharacterized protein.	RecQ-mediated genome instability protein 1.	0.400
CTC1	STK40	ENSCJAP00000026707	ENSCJAP00000065068	CST telomere replication complex component 1.	Serine/threonine-protein kinase 40.	0.837
DUOX2	SP2	ENSCJAP00000078321	ENSCJAP00000014318	Dual oxidase 2.	Sp2 transcription factor.	0.625
ENSCJAP00000062412	EP300	ENSCJAP00000062412	ENSCJAP00000008779	Kruppel like factor 2.	E1A binding protein p300.	0.501
EP300	AR	ENSCJAP00000008779	ENSCJAP00000006494	E1A binding protein p300.	Androgen receptor.	0.789
EP300	ATM	ENSCJAP00000008779	ENSCJAP00000018844	E1A binding protein p300.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.557
EP300	ENSCJAP00000062412	ENSCJAP00000008779	ENSCJAP00000062412	E1A binding protein p300.	Kruppel like factor 2.	0.501