(61 nodes) Homologous chromosome segregation network (Callithrix jacchus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	BRIP1	Uncharacterized protein. (213 aa)
	CCNE2	G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
	CCDC155	Coiled-coil domain containing 155. (562 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (864 aa)
	CCNE1	G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
	MND1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (205 aa)
	TERB2	Telomere repeat binding bouquet formation protein 2. (221 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1268 aa)
	MSH5	DNA_MISMATCH_REPAIR_2 domain-containing protein. (834 aa)
	SGO1	Shugoshin 1. (528 aa)
	CCDC36	Coiled-coil domain containing 36. (600 aa)
	SGO2	Shugoshin 2. (1259 aa)
	SYCE2	Synaptonemal complex central element protein 2. (216 aa)
	TMEM48	NDC1 transmembrane nucleoporin. (674 aa)
	PSMC3IP	PSMC3 interacting protein. (217 aa)
	MSH4	MutS homolog 4. (935 aa)
	TEX11	Testis expressed 11. (925 aa)
	CCNB1IP1	E3 ubiquitin-protein ligase CCNB1IP1. (277 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	PRDM7	Uncharacterized protein. (814 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (339 aa)
	TEX12	Testis expressed 12. (123 aa)
	SYCP1	Synaptonemal complex protein 1. (906 aa)
	SYCE1L	Synaptonemal complex central element protein 1 like. (240 aa)
	MEIOB	Meiosis specific with OB-fold. (470 aa)
	ZCWPW1	Zinc finger CW-type and PWWP domain containing 1. (647 aa)
	STAG3	Stromal antigen 3. (1225 aa)
	FANCD2	FA complementation group D2. (1453 aa)
	TERB1	Telomere repeat binding bouquet formation protein 1. (725 aa)
	MAEL	Maelstrom spermatogenic transposon silencer. (403 aa)
	C1orf146	Chromosome 1 open reading frame 146. (180 aa)
	SIRT7	NAD-dependent protein deacetylase sirtuin-7. (400 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2121 aa)
	SYCP2	Synaptonemal complex protein 2. (1623 aa)
	C14orf39	Chromosome 14 open reading frame 39. (586 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (396 aa)
	PTTG1	PTTG1 regulator of sister chromatid separation, securin. (202 aa)
	SPATA22	Uncharacterized protein. (363 aa)
	MLH3	MutL homolog 3. (1456 aa)
	PLK1	Serine/threonine-protein kinase PLK. (597 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (384 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (954 aa)
	P3H4	Prolyl 3-hydroxylase family member 4 (non-enzymatic). (437 aa)
	HORMAD1	HORMA domain containing 1. (393 aa)
	SUN1	Sad1 and UNC84 domain containing 1. (910 aa)
	ENSCJAP00000055029	Ubiquitin-like domain-containing protein. (1028 aa)
	ENSCJAP00000055243	Uncharacterized protein. (363 aa)
	ENSCJAP00000058369	Cyclin_C domain-containing protein; Belongs to the cyclin family. (358 aa)
	TEX15	Testis expressed 15, meiosis and synapsis associated. (3169 aa)
	SYCE3	Synaptonemal complex central element protein 3. (88 aa)
	MEIKIN	Meiotic kinetochore factor. (373 aa)
	ANKRD31	Ankyrin repeat domain 31. (1929 aa)
	MLH1	MutL homolog 1. (820 aa)
	ENSCJAP00000071263	Helicase ATP-binding domain-containing protein. (88 aa)
	TERF1	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (452 aa)
	CENPC	Centromere protein C. (1150 aa)
	SYCE1	Synaptonemal complex central element protein 1. (341 aa)
	BAG6	Ubiquitin-like domain-containing protein. (1119 aa)
	ENSCJAP00000074663	Uncharacterized protein. (347 aa)
	REC8	REC8 meiotic recombination protein. (528 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (469 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD31	CCDC36	ENSCJAP00000066856	ENSCJAP00000006819	Ankyrin repeat domain 31.	Coiled-coil domain containing 36.	0.550
ANKRD31	PRDM7	ENSCJAP00000066856	ENSCJAP00000019247	Ankyrin repeat domain 31.	Uncharacterized protein.	0.469
ANKRD31	SYCE1	ENSCJAP00000066856	ENSCJAP00000074200	Ankyrin repeat domain 31.	Synaptonemal complex central element protein 1.	0.473
ANKRD31	SYCE2	ENSCJAP00000066856	ENSCJAP00000008596	Ankyrin repeat domain 31.	Synaptonemal complex central element protein 2.	0.422
ANKRD31	SYCP1	ENSCJAP00000066856	ENSCJAP00000023315	Ankyrin repeat domain 31.	Synaptonemal complex protein 1.	0.524
ANKRD31	TEX15	ENSCJAP00000066856	ENSCJAP00000058967	Ankyrin repeat domain 31.	Testis expressed 15, meiosis and synapsis associated.	0.425
ATM	BRIP1	ENSCJAP00000018844	ENSCJAP00000077778	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.810
ATM	DMC1	ENSCJAP00000018844	ENSCJAP00000021648	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.721
ATM	ENSCJAP00000071263	ENSCJAP00000018844	ENSCJAP00000071263	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Helicase ATP-binding domain-containing protein.	0.684
ATM	FANCD2	ENSCJAP00000018844	ENSCJAP00000030098	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group D2.	0.851
ATM	HORMAD1	ENSCJAP00000018844	ENSCJAP00000050371	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	HORMA domain containing 1.	0.474
ATM	MEIOB	ENSCJAP00000018844	ENSCJAP00000027204	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiosis specific with OB-fold.	0.812
ATM	MLH1	ENSCJAP00000018844	ENSCJAP00000069380	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 1.	0.894
ATM	MLH3	ENSCJAP00000018844	ENSCJAP00000038288	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 3.	0.830
ATM	MSH4	ENSCJAP00000018844	ENSCJAP00000012606	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutS homolog 4.	0.737
ATM	MSH5	ENSCJAP00000018844	ENSCJAP00000005058	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.643
ATM	PLK1	ENSCJAP00000018844	ENSCJAP00000038355	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase PLK.	0.515
ATM	SPO11	ENSCJAP00000018844	ENSCJAP00000035571	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SPO11 initiator of meiotic double stranded breaks.	0.763
ATM	SYCP1	ENSCJAP00000018844	ENSCJAP00000023315	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Synaptonemal complex protein 1.	0.460
ATM	TERF1	ENSCJAP00000018844	ENSCJAP00000071851	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.	0.657