(35 nodes) Myoblast differentiation network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCJAP00000073738	HMG box domain-containing protein. (322 aa)
	TBXT	T-box transcription factor T. (448 aa)
	PLEC	Plectin. (6199 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	RB1	Retinoblastoma-associated protein. (927 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	WNT10B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	DDX5	Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (614 aa)
	MEGF10	Multiple EGF like domains 10. (1142 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
	HINFP	Histone H4 transcription factor. (516 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (1087 aa)
	BCL9L	B-cell CLL/lymphoma 9-like protein. (1497 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (729 aa)
	NOTCH1	Notch receptor 1. (2551 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	SOX15	SRY-box transcription factor 15. (233 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (348 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	PLEKHM3	Pleckstrin homology domain-containing family M member 3. (760 aa)
	REST	RE1 silencing transcription factor. (1076 aa)
	MBNL1	Muscleblind-like protein 1 isoform c. (399 aa)
	IGF1	Insulin like growth factor 1. (197 aa)
	IFRD1	Interferon-related developmental regulator 1 isoform 1. (452 aa)
	ENSCJAP00000065650	Transcription factor 7 like 2. (649 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1013 aa)
	LGALS1	Galectin. (201 aa)
	MYOCD	Myocardin isoform 1. (982 aa)
	SRF	Serum response factor. (509 aa)
	NRG1	Neuregulin 1. (713 aa)
	PITX1	Homeobox protein. (314 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	EPAS1	Endothelial PAS domain protein 1. (871 aa)
	MAPK12	Mitogen-activated protein kinase. (466 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX17	DDX5	ENSCJAP00000021792	ENSCJAP00000035916	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	0.906
DDX17	MYOD1	ENSCJAP00000021792	ENSCJAP00000044953	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.566
DDX5	DDX17	ENSCJAP00000035916	ENSCJAP00000021792	Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.906
DDX5	MYOD1	ENSCJAP00000035916	ENSCJAP00000044953	Putative ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.484
EPAS1	IGF1	ENSCJAP00000072695	ENSCJAP00000056775	Endothelial PAS domain protein 1.	Insulin like growth factor 1.	0.646
EPAS1	NOTCH1	ENSCJAP00000072695	ENSCJAP00000020179	Endothelial PAS domain protein 1.	Notch receptor 1.	0.583
FGF6	IGF1	ENSCJAP00000002890	ENSCJAP00000056775	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin like growth factor 1.	0.549
FGF6	SDC1	ENSCJAP00000002890	ENSCJAP00000026814	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.579
FGF6	SHH	ENSCJAP00000002890	ENSCJAP00000037954	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.408
IGF1	EPAS1	ENSCJAP00000056775	ENSCJAP00000072695	Insulin like growth factor 1.	Endothelial PAS domain protein 1.	0.646
IGF1	FGF6	ENSCJAP00000056775	ENSCJAP00000002890	Insulin like growth factor 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.549
IGF1	MYOD1	ENSCJAP00000056775	ENSCJAP00000044953	Insulin like growth factor 1.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.552
IGF1	SHH	ENSCJAP00000056775	ENSCJAP00000037954	Insulin like growth factor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.478
ISL1	SHH	ENSCJAP00000020012	ENSCJAP00000037954	Insulin gene enhancer protein ISL-1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.514
ISL1	TBX2	ENSCJAP00000020012	ENSCJAP00000002233	Insulin gene enhancer protein ISL-1.	T-box transcription factor 2.	0.494
ITGB1	PLEC	ENSCJAP00000025265	ENSCJAP00000075152	Integrin beta; Belongs to the integrin beta chain family.	Plectin.	0.478
ITGB1	SDC1	ENSCJAP00000025265	ENSCJAP00000026814	Integrin beta; Belongs to the integrin beta chain family.	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.	0.512
ITGB1	SRF	ENSCJAP00000025265	ENSCJAP00000009562	Integrin beta; Belongs to the integrin beta chain family.	Serum response factor.	0.559
JAG1	MAML1	ENSCJAP00000039752	ENSCJAP00000066353	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind like transcriptional coactivator 1.	0.712
JAG1	NOTCH1	ENSCJAP00000039752	ENSCJAP00000020179	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.978