STRINGSTRING
RHOH RHOH STAT5B STAT5B NFKBIZ NFKBIZ CD27 CD27 ZMIZ1 ZMIZ1 SART1 SART1 AMBRA1 AMBRA1 PRKCZ PRKCZ SMARCC1 SMARCC1 RUNX1 RUNX1 CD46 CD46 IL4I1 IL4I1 TGFBR2 TGFBR2 ADAM8 ADAM8 SYK SYK DUSP10 DUSP10 SMARCA4 SMARCA4 F7HE85_CALJA F7HE85_CALJA PBRM1 PBRM1 GLI3 GLI3 MYB MYB CD86 CD86 IL1RL2 IL1RL2 PNP PNP NFKBID NFKBID ARID1A ARID1A SHB SHB SMARCA2 SMARCA2 SMARCB1 SMARCB1 ZAP70 ZAP70 SMARCC2 SMARCC2 NLRP3 NLRP3 MDK MDK ZBTB16 ZBTB16 IL18 IL18 ITPKB ITPKB IL4 IL4 ARID2 ARID2 AP3D1 AP3D1 F7H2X0_CALJA F7H2X0_CALJA RARA RARA BCL6 BCL6 ACTL6B ACTL6B TNFSF9 TNFSF9 SOX13 SOX13 ADA ADA BAD BAD F6RII0_CALJA F6RII0_CALJA IL7R IL7R NCKAP1L NCKAP1L TESPA1 TESPA1 SMARCD2 SMARCD2 SMARCD3 SMARCD3 AP3B1 AP3B1 XBP1 XBP1 F6W0Z8_CALJA F6W0Z8_CALJA TGFB1 TGFB1 SHH SHH WNT10B WNT10B RASGRP1 RASGRP1 SMARCD1 SMARCD1 ZBTB7B ZBTB7B PTPRC PTPRC SMARCE1 SMARCE1 PIK3R6 PIK3R6 SASH3 SASH3 IL23R IL23R ZBTB1 ZBTB1 ENSCJAP00000053016 ENSCJAP00000053016 GATA3 GATA3 RUNX3 RUNX3 ENSCJAP00000054448 ENSCJAP00000054448 IHH IHH PHF10 PHF10 CBFB CBFB FOXP3 FOXP3 IFNG IFNG IL12RB1 IL12RB1 LEF1 LEF1 ENSCJAP00000058816 ENSCJAP00000058816 IL23A IL23A PCK1 PCK1 CD83 CD83 SOX12 SOX12 TNFSF4 TNFSF4 RAG1 RAG1 RIPK2 RIPK2 ENSCJAP00000065525 ENSCJAP00000065525 SOCS5 SOCS5 IL7 IL7 SOX4 SOX4 CD74 CD74 MALT1 MALT1 ANXA1 ANXA1 VSIR VSIR ENSCJAP00000069435 ENSCJAP00000069435 ENSCJAP00000070453 ENSCJAP00000070453 ENSCJAP00000071395 ENSCJAP00000071395 SOCS1 SOCS1 CCL19 CCL19 IL4R IL4R VNN1 VNN1 ARID1B ARID1B ENSCJAP00000075433 ENSCJAP00000075433 KAT5 KAT5 IL2RG IL2RG CD80 CD80 EGR3 EGR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOHRas homolog family member H. (191 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
NFKBIZNF-kappa-B inhibitor zeta isoform a. (712 aa)
CD27CD27 molecule. (320 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1066 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (798 aa)
AMBRA1Uncharacterized protein. (473 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1105 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
CD46Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). (407 aa)
IL4I1Amine oxidase. (590 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (593 aa)
ADAM8ADAM metallopeptidase domain 8. (825 aa)
SYKUncharacterized protein. (636 aa)
DUSP10Dual specificity protein phosphatase 10 isoform a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1669 aa)
F7HE85_CALJAHMG box domain-containing protein. (411 aa)
PBRM1Polybromo 1. (1725 aa)
GLI3GLI family zinc finger 3. (1578 aa)
MYBMYB proto-oncogene, transcription factor. (761 aa)
CD86Ig-like domain-containing protein. (361 aa)
IL1RL2Interleukin 1 receptor like 2. (620 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
NFKBIDNFKB inhibitor delta. (467 aa)
ARID1AAT-rich interaction domain 1A. (2288 aa)
SHBSH2 domain containing adaptor protein B. (509 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1590 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (409 aa)
ZAP70Zeta chain of T cell receptor associated protein kinase 70. (648 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa)
NLRP3NLR family pyrin domain containing 3. (1034 aa)
MDKMidkine isoform a. (144 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (947 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (151 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
AP3D1Adaptor related protein complex 3 subunit delta 1. (1217 aa)
F7H2X0_CALJAGLI family zinc finger 2. (1586 aa)
RARAUncharacterized protein. (468 aa)
BCL6B-cell lymphoma 6 protein isoform 1. (706 aa)
ACTL6BActin-like protein 6B; Belongs to the actin family. (426 aa)
TNFSF9TNF superfamily member 9; Belongs to the tumor necrosis factor family. (251 aa)
SOX13SRY-box transcription factor 13. (615 aa)
ADAAdenosine deaminase. (363 aa)
BADBcl2 antagonist of cell death. (167 aa)
F6RII0_CALJAUncharacterized protein. (692 aa)
IL7RInterleukin-7 receptor subunit alpha; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity); Belongs to the type I cytokine receptor family. Type 4 subfamily. (459 aa)
NCKAP1LNCK associated protein 1 like. (1128 aa)
TESPA1Thymocyte expressed, positive selection associated 1. (522 aa)
SMARCD2SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2. (531 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (600 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa)
XBP1BZIP domain-containing protein. (371 aa)
F6W0Z8_CALJAAIG1-type G domain-containing protein. (306 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
RASGRP1RAS guanyl releasing protein 1. (826 aa)
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1. (515 aa)
ZBTB7BZinc finger and BTB domain-containing protein 7B isoform 2. (573 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1252 aa)
SMARCE1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1. (411 aa)
PIK3R6Uncharacterized protein. (754 aa)
SASH3SAM and SH3 domain-containing protein 3. (380 aa)
IL23RInterleukin 23 receptor. (630 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
ENSCJAP00000053016WD_REPEATS_REGION domain-containing protein. (1298 aa)
GATA3GATA binding protein 3. (444 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (430 aa)
ENSCJAP00000054448Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PHF10PHD finger protein 10. (562 aa)
CBFBCore-binding factor subunit beta isoform 1. (187 aa)
FOXP3Forkhead box P3. (478 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
IL12RB1Interleukin 12 receptor subunit beta 1. (663 aa)
LEF1Lymphoid enhancer binding factor 1. (419 aa)
ENSCJAP00000058816Uncharacterized protein. (103 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
CD83CD83 antigen isoform a. (201 aa)
SOX12Transcription factor SOX. (314 aa)
TNFSF4Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (539 aa)
ENSCJAP00000065525SWIB domain-containing protein. (481 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
SOX4Transcription factor SOX. (472 aa)
CD74CD74 molecule. (300 aa)
MALT1MALT1 paracaspase. (824 aa)
ANXA1Annexin. (403 aa)
VSIRIg-like domain-containing protein. (364 aa)
ENSCJAP00000069435HMG box domain-containing protein. (110 aa)
ENSCJAP00000070453Uncharacterized protein. (466 aa)
ENSCJAP00000071395BZIP domain-containing protein. (345 aa)
SOCS1Suppressor of cytokine signaling 1. (211 aa)
CCL19C-C motif chemokine. (104 aa)
IL4RFibronectin type-III domain-containing protein. (1028 aa)
VNN1Vanin 1. (547 aa)
ARID1BAT-rich interaction domain 1B. (2420 aa)
ENSCJAP00000075433HMG box domain-containing protein. (137 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (556 aa)
IL2RGFibronectin type-III domain-containing protein. (374 aa)
CD80Uncharacterized protein. (348 aa)
EGR3Early growth response protein 3 isoform 1. (387 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (18%) [HD]