STRINGSTRING
AREG AREG RORB RORB SMAD3 SMAD3 FNDC3B FNDC3B SKI SKI MEN1 MEN1 TNFAIP6 TNFAIP6 NOCT NOCT HOXA2 HOXA2 TNN TNN UCMA UCMA HDAC7 HDAC7 NOTCH1 NOTCH1 SFRP1 SFRP1 BAMBI BAMBI GDF10 GDF10 CHRD CHRD AXIN2 AXIN2 SUFU SUFU SEMA4D SEMA4D CITED1 CITED1 TNF TNF VEGFC VEGFC C14orf169 C14orf169 NOG NOG SMAD6 SMAD6 GREM2 GREM2 PTCH1 PTCH1 RANBP3L RANBP3L ENSCJAP00000070021 ENSCJAP00000070021 FGF23 FGF23 IGFBP5 IGFBP5 TMEM64 TMEM64 SOX9 SOX9 CRIM1 CRIM1 CDK6 CDK6 ID3 ID3 TWSG1 TWSG1 HAND2 HAND2 OSTN OSTN ENSCJAP00000076540 ENSCJAP00000076540 TRPM4 TRPM4 F7GYC0_CALJA F7GYC0_CALJA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AREGAmphiregulin. (275 aa)
RORBRAR related orphan receptor B. (470 aa)
SMAD3Mothers against decapentaplegic homolog. (437 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1204 aa)
SKISKI proto-oncogene. (729 aa)
MEN1Menin isoform 2 (Predicted). (606 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (277 aa)
NOCTNocturnin. (428 aa)
HOXA2Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (375 aa)
TNNTenascin N. (1299 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (132 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (990 aa)
NOTCH1Notch receptor 1. (2551 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (478 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (967 aa)
AXIN2Axin-2. (842 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (485 aa)
SEMA4DSemaphorin-4D isoform 1; Belongs to the semaphorin family. (862 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform 2. (220 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (402 aa)
C14orf169Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (631 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD6Mothers against decapentaplegic homolog. (498 aa)
GREM2Gremlin. (168 aa)
PTCH1Protein patched homolog 1 isoform L. (1449 aa)
RANBP3LRAN binding protein 3 like. (465 aa)
ENSCJAP00000070021Uncharacterized protein. (129 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (300 aa)
IGFBP5Insulin like growth factor binding protein 5. (275 aa)
TMEM64Transmembrane protein 64. (401 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
CRIM1Cysteine rich transmembrane BMP regulator 1. (1036 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
ID3DNA-binding protein inhibitor ID-3. (119 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (219 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
OSTNOsteocrin. (172 aa)
ENSCJAP00000076540BHLH domain-containing protein. (120 aa)
TRPM4Uncharacterized protein. (31 aa)
F7GYC0_CALJAUncharacterized protein. (227 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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