(42 nodes) Thymus development network (Callithrix jacchus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (507 aa)
	FADD	Fas associated via death domain. (284 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	BCL2L11	BCL2 like 11. (249 aa)
	SRF	Serum response factor. (509 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1240 aa)
	PAX1	Paired box 1. (454 aa)
	RIPK3	Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (475 aa)
	HOXA3	Homeobox A3 isoform a (Predicted). (443 aa)
	BCL11B	BAF chromatin remodeling complex subunit BCL11B. (938 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
	BRAF	Uncharacterized protein. (805 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	CCNB2	Cyclin B2; Belongs to the cyclin family. (270 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (718 aa)
	BCL2	BCL2 apoptosis regulator. (240 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	ENSCJAP00000069517	Uncharacterized protein. (251 aa)
	CRKL	Crk-like protein. (303 aa)
	EPHB3	EPH receptor B3. (1013 aa)
	CACNB4	Voltage-dependent L-type calcium channel subunit beta-4 isoform c. (502 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	LMO4	Uncharacterized protein. (218 aa)
	CITED2	Uncharacterized protein. (273 aa)
	FOXE1	Forkhead box E1. (371 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	GATA3	GATA binding protein 3. (444 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (644 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	ASXL1	ASXL transcriptional regulator 1. (1542 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	SIX4	SIX homeobox 4. (781 aa)
	CTNNB1	Catenin beta 1. (774 aa)
	SLC46A2	Solute carrier family 46 member 2. (474 aa)
	TYR	Tyrosinase. (530 aa)
	TBX1	T-box transcription factor 1. (506 aa)
	CTC1	CST telomere replication complex component 1. (1217 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
	AIRE	Autoimmune regulator. (392 aa)
	FOXN1	Forkhead box N1. (647 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ASXL1	ENSCJAP00000066744	ENSCJAP00000038524	Tyrosine-protein kinase.	ASXL transcriptional regulator 1.	0.476
ABL1	ATM	ENSCJAP00000066744	ENSCJAP00000018844	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.902
ABL1	CRKL	ENSCJAP00000066744	ENSCJAP00000071541	Tyrosine-protein kinase.	Crk-like protein.	0.987
ABL1	CTNNB1	ENSCJAP00000066744	ENSCJAP00000033154	Tyrosine-protein kinase.	Catenin beta 1.	0.719
ABL1	EPHB3	ENSCJAP00000066744	ENSCJAP00000071736	Tyrosine-protein kinase.	EPH receptor B3.	0.919
ABL1	MAPK1	ENSCJAP00000066744	ENSCJAP00000045173	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.575
ABL1	MAPK3	ENSCJAP00000066744	ENSCJAP00000058446	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.504
AIRE	FOXN1	ENSCJAP00000025299	ENSCJAP00000023278	Autoimmune regulator.	Forkhead box N1.	0.685
AIRE	ZMPSTE24	ENSCJAP00000025299	ENSCJAP00000005168	Autoimmune regulator.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.414
ASXL1	ABL1	ENSCJAP00000038524	ENSCJAP00000066744	ASXL transcriptional regulator 1.	Tyrosine-protein kinase.	0.476
ATM	ABL1	ENSCJAP00000018844	ENSCJAP00000066744	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.902
ATM	BCL2	ENSCJAP00000018844	ENSCJAP00000066653	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.545
ATM	BRAF	ENSCJAP00000018844	ENSCJAP00000060924	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.582
ATM	TGFBR1	ENSCJAP00000018844	ENSCJAP00000020730	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.418
BCL11B	GATA3	ENSCJAP00000056776	ENSCJAP00000053176	BAF chromatin remodeling complex subunit BCL11B.	GATA binding protein 3.	0.434
BCL2	ATM	ENSCJAP00000066653	ENSCJAP00000018844	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.545
BCL2	BCL2L11	ENSCJAP00000066653	ENSCJAP00000008093	BCL2 apoptosis regulator.	BCL2 like 11.	0.973
BCL2	BRAF	ENSCJAP00000066653	ENSCJAP00000060924	BCL2 apoptosis regulator.	Uncharacterized protein.	0.622
BCL2	CTNNB1	ENSCJAP00000066653	ENSCJAP00000033154	BCL2 apoptosis regulator.	Catenin beta 1.	0.511
BCL2	FADD	ENSCJAP00000066653	ENSCJAP00000001586	BCL2 apoptosis regulator.	Fas associated via death domain.	0.683