(26 nodes) Embryonic camera-type eye morphogenesis network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP7	Bone morphogenetic protein 7. (430 aa)
	ENSCJAP00000069517	Uncharacterized protein. (251 aa)
	TH	Tyrosine hydroxylase. (623 aa)
	PAX2	Paired box 2. (448 aa)
	FOXF2	Forkhead box F2. (448 aa)
	SOX11	Transcription factor SOX. (448 aa)
	PHACTR4	Phosphatase and actin regulator. (713 aa)
	PAX6	Paired box 6. (472 aa)
	ENSCJAP00000054910	Uncharacterized protein. (406 aa)
	CITED2	Uncharacterized protein. (273 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	STRA6	Stimulated by retinoic acid 6. (706 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	ZEB1	Zinc finger E-box-binding homeobox 1 isoform f. (1126 aa)
	FZD5	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	HIPK2	Homeodomain-interacting protein kinase 2 isoform 1. (1196 aa)
	HIPK1	Uncharacterized protein. (1416 aa)
	SP3	Sp3 transcription factor. (782 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	KDM2B	Lysine demethylase 2B. (1246 aa)
	TBX2	T-box transcription factor 2. (713 aa)
	SIX3	SIX homeobox 3. (331 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1A3	STRA6	ENSCJAP00000031623	ENSCJAP00000051445	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	Stimulated by retinoic acid 6.	0.528
BMP7	IHH	ENSCJAP00000070399	ENSCJAP00000054739	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.662
CITED2	TFAP2A	ENSCJAP00000056544	ENSCJAP00000039671	Uncharacterized protein.	Transcription factor AP-2 alpha.	0.663
ENSCJAP00000069517	TFAP2A	ENSCJAP00000069517	ENSCJAP00000039671	Uncharacterized protein.	Transcription factor AP-2 alpha.	0.663
FZD5	SIX3	ENSCJAP00000041103	ENSCJAP00000001262	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	SIX homeobox 3.	0.408
FZD5	WNT16	ENSCJAP00000041103	ENSCJAP00000077657	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.849
FZD5	WNT5A	ENSCJAP00000041103	ENSCJAP00000014370	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.984
IHH	BMP7	ENSCJAP00000054739	ENSCJAP00000070399	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 7.	0.662
PAX6	SIX3	ENSCJAP00000057969	ENSCJAP00000001262	Paired box 6.	SIX homeobox 3.	0.787
PAX6	SOX11	ENSCJAP00000057969	ENSCJAP00000066035	Paired box 6.	Transcription factor SOX.	0.418
PAX6	SP3	ENSCJAP00000057969	ENSCJAP00000014566	Paired box 6.	Sp3 transcription factor.	0.431
PAX6	TH	ENSCJAP00000057969	ENSCJAP00000068563	Paired box 6.	Tyrosine hydroxylase.	0.535
SIX3	FZD5	ENSCJAP00000001262	ENSCJAP00000041103	SIX homeobox 3.	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family.	0.408
SIX3	PAX6	ENSCJAP00000001262	ENSCJAP00000057969	SIX homeobox 3.	Paired box 6.	0.787
SOX11	PAX6	ENSCJAP00000066035	ENSCJAP00000057969	Transcription factor SOX.	Paired box 6.	0.418
SP3	PAX6	ENSCJAP00000014566	ENSCJAP00000057969	Sp3 transcription factor.	Paired box 6.	0.431
STRA6	ALDH1A3	ENSCJAP00000051445	ENSCJAP00000031623	Stimulated by retinoic acid 6.	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family.	0.528
TFAP2A	CITED2	ENSCJAP00000039671	ENSCJAP00000056544	Transcription factor AP-2 alpha.	Uncharacterized protein.	0.663
TFAP2A	ENSCJAP00000069517	ENSCJAP00000039671	ENSCJAP00000069517	Transcription factor AP-2 alpha.	Uncharacterized protein.	0.663
TH	PAX6	ENSCJAP00000068563	ENSCJAP00000057969	Tyrosine hydroxylase.	Paired box 6.	0.535