(43 nodes) Oocyte development network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZGLP1	Zinc finger GATA like protein 1. (293 aa)
	ENSCJAP00000074992	Uncharacterized protein. (116 aa)
	REC8	REC8 meiotic recombination protein. (528 aa)
	TDRD6	Tudor domain containing 6. (2118 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (469 aa)
	RPS6KA2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (721 aa)
	PDE3A	Phosphodiesterase. (1141 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (954 aa)
	TUT4	Terminal uridylyltransferase 4 isoform a. (1634 aa)
	CDC25B	Cell division cycle 25B. (588 aa)
	PTK2B	Protein-tyrosine kinase 2-beta isoform a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	TDRD1	Tudor domain containing 1. (1184 aa)
	CTNNB1	Catenin beta 1. (774 aa)
	BRCA2	BRCA2 DNA repair associated. (3409 aa)
	PABPC1L	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (614 aa)
	YTHDC2	YTH domain containing 2. (1416 aa)
	F6Y5L6_CALJA	CSD_1 domain-containing protein. (358 aa)
	FBXO5	F-box protein 5. (444 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (339 aa)
	DMRT1	Doublesex and mab-3 related transcription factor 1. (378 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	TDRD5	Tudor domain containing 5. (1034 aa)
	TDRKH	Tudor and KH domain containing isoform a (Predicted). (560 aa)
	PLD6	Phospholipase D family member 6. (243 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1268 aa)
	EDNRA	Endothelin-1 receptor isoform a; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	TUT7	Terminal uridylyl transferase 7. (1490 aa)
	AURKC	Aurora kinase C isoform 1; Belongs to the protein kinase superfamily. (309 aa)
	YTHDF2	YTH domain family protein 2 isoform 1. (579 aa)
	WDR77	Methylosome protein 50. (342 aa)
	FIGLA	Folliculogenesis specific bHLH transcription factor. (219 aa)
	PDE5A	Phosphodiesterase. (875 aa)
	MTHFSD	Methenyltetrahydrofolate synthase domain-containing protein isoform 4. (382 aa)
	ENSCJAP00000057591	CSD_1 domain-containing protein. (358 aa)
	FOXL2	Forkhead box L2. (376 aa)
	INHBB	Inhibin subunit beta B. (407 aa)
	EDN1	Endothelin-1 isoform 1 preproprotein. (213 aa)
	TDRD10	Tudor domain containing 10. (365 aa)
	EREG	Epiregulin. (169 aa)
	BCL2	BCL2 apoptosis regulator. (240 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	KMT2D	Uncharacterized protein. (743 aa)
	TDRD15	Tudor domain containing 15. (1937 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	ENSCJAP00000018844	ENSCJAP00000066653	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.545
ATM	BRCA2	ENSCJAP00000018844	ENSCJAP00000034250	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.966
ATM	CDC25B	ENSCJAP00000018844	ENSCJAP00000039482	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cell division cycle 25B.	0.440
ATM	DMC1	ENSCJAP00000018844	ENSCJAP00000021648	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.721
AURKC	TRIP13	ENSCJAP00000000030	ENSCJAP00000077693	Aurora kinase C isoform 1; Belongs to the protein kinase superfamily.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.509
BCL2	ATM	ENSCJAP00000066653	ENSCJAP00000018844	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.545
BCL2	CTNNB1	ENSCJAP00000066653	ENSCJAP00000033154	BCL2 apoptosis regulator.	Catenin beta 1.	0.511
BCL2	DMRT1	ENSCJAP00000066653	ENSCJAP00000019669	BCL2 apoptosis regulator.	Doublesex and mab-3 related transcription factor 1.	0.448
BRCA2	ATM	ENSCJAP00000034250	ENSCJAP00000018844	BRCA2 DNA repair associated.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.966
BRCA2	DMC1	ENSCJAP00000034250	ENSCJAP00000021648	BRCA2 DNA repair associated.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.904
CDC25B	ATM	ENSCJAP00000039482	ENSCJAP00000018844	Cell division cycle 25B.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.440
CDC25B	PDE3A	ENSCJAP00000039482	ENSCJAP00000045375	Cell division cycle 25B.	Phosphodiesterase.	0.432
CDC25B	TRIP13	ENSCJAP00000039482	ENSCJAP00000077693	Cell division cycle 25B.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.448
CTNNB1	BCL2	ENSCJAP00000033154	ENSCJAP00000066653	Catenin beta 1.	BCL2 apoptosis regulator.	0.511
CTNNB1	DMRT1	ENSCJAP00000033154	ENSCJAP00000019669	Catenin beta 1.	Doublesex and mab-3 related transcription factor 1.	0.511
CTNNB1	ENSCJAP00000074992	ENSCJAP00000033154	ENSCJAP00000074992	Catenin beta 1.	Uncharacterized protein.	0.539
CTNNB1	KMT2D	ENSCJAP00000033154	ENSCJAP00000068992	Catenin beta 1.	Uncharacterized protein.	0.539
CTNNB1	WNT4	ENSCJAP00000033154	ENSCJAP00000067759	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.666
DMC1	ATM	ENSCJAP00000021648	ENSCJAP00000018844	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.721
DMC1	BRCA2	ENSCJAP00000021648	ENSCJAP00000034250	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	BRCA2 DNA repair associated.	0.904