(52 nodes) Astrocyte differentiation network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TTC21B	Tetratricopeptide repeat domain 21B. (1315 aa)
	STAT3	Signal transducer and activator of transcription. (771 aa)
	F7HFW4_CALJA	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (852 aa)
	HES5	Hes family bHLH transcription factor 5. (162 aa)
	SOX8	SRY-box transcription factor 8. (538 aa)
	LAMB2	Laminin subunit beta 2. (1798 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (89 aa)
	LRP1	Prolow-density lipoprotein receptor-related protein 1. (4544 aa)
	LAMC3	Laminin subunit gamma 3. (1577 aa)
	ADORA2A	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (413 aa)
	GRN	Granulin precursor. (592 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
	NOTCH1	Notch receptor 1. (2551 aa)
	GCM1	Glial cells missing transcription factor 1. (437 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
	EIF2B5	Eukaryotic translation initiation factor 2B subunit epsilon. (866 aa)
	APP	Amyloid beta A4 protein isoform a. (770 aa)
	NF1	Neurofibromin 1. (2839 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
	PLPP3	Lipid phosphate phosphohydrolase 3. (311 aa)
	LAMB1	Laminin subunit beta 1. (1788 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	PLP1	Myelin proteolipid protein isoform 1. (277 aa)
	F7FT97_CALJA	Homeobox domain-containing protein. (286 aa)
	GPR37L1	G protein-coupled receptor 37 like 1. (481 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
	ENSCJAP00000075321	Ig-like domain-containing protein. (197 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (388 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (421 aa)
	AGER	Advanced glycosylation end-product specific receptor. (419 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (921 aa)
	EOMES	Eomesodermin. (706 aa)
	ENSCJAP00000054059	Ig-like domain-containing protein. (88 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	PAX6	Paired box 6. (472 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	ID4	Inhibitor of DNA binding 4, HLH protein. (161 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (504 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (761 aa)
	TSPAN2	Tetraspanin. (221 aa)
	ENSCJAP00000072238	Homeobox domain-containing protein. (270 aa)
	S100A9	S100 calcium binding protein A9; Belongs to the S-100 family. (125 aa)
	C1QA	Complement C1q subcomponent subunit A. (245 aa)
	BMP2	Bone morphogenetic protein 2. (401 aa)
	IFNGR1	Interferon gamma receptor 1. (475 aa)
	ENSCJAP00000077270	Homeobox domain-containing protein. (263 aa)
	ENSCJAP00000077578	Kringle domain-containing protein. (125 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	MAPK1	ENSCJAP00000066744	ENSCJAP00000045173	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.575
ABL1	MAPK3	ENSCJAP00000066744	ENSCJAP00000058446	Tyrosine-protein kinase.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.504
ABL1	STAT3	ENSCJAP00000066744	ENSCJAP00000000719	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.436
AGER	APP	ENSCJAP00000046914	ENSCJAP00000025684	Advanced glycosylation end-product specific receptor.	Amyloid beta A4 protein isoform a.	0.637
AGER	LRP1	ENSCJAP00000046914	ENSCJAP00000013997	Advanced glycosylation end-product specific receptor.	Prolow-density lipoprotein receptor-related protein 1.	0.418
AGER	S100A9	ENSCJAP00000046914	ENSCJAP00000072393	Advanced glycosylation end-product specific receptor.	S100 calcium binding protein A9; Belongs to the S-100 family.	0.602
APP	AGER	ENSCJAP00000025684	ENSCJAP00000046914	Amyloid beta A4 protein isoform a.	Advanced glycosylation end-product specific receptor.	0.637
APP	GFAP	ENSCJAP00000025684	ENSCJAP00000066163	Amyloid beta A4 protein isoform a.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.636
APP	LRP1	ENSCJAP00000025684	ENSCJAP00000013997	Amyloid beta A4 protein isoform a.	Prolow-density lipoprotein receptor-related protein 1.	0.707
APP	NOTCH1	ENSCJAP00000025684	ENSCJAP00000020179	Amyloid beta A4 protein isoform a.	Notch receptor 1.	0.476
APP	PSEN1	ENSCJAP00000025684	ENSCJAP00000026553	Amyloid beta A4 protein isoform a.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.984
APP	SHH	ENSCJAP00000025684	ENSCJAP00000037954	Amyloid beta A4 protein isoform a.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.401
APP	TREM2	ENSCJAP00000025684	ENSCJAP00000045567	Amyloid beta A4 protein isoform a.	Triggering receptor expressed on myeloid cells 2.	0.607
BMP2	SHH	ENSCJAP00000073814	ENSCJAP00000037954	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.438
BMP2	SOX9	ENSCJAP00000073814	ENSCJAP00000067837	Bone morphogenetic protein 2.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.534
C1QA	TREM2	ENSCJAP00000073701	ENSCJAP00000045567	Complement C1q subcomponent subunit A.	Triggering receptor expressed on myeloid cells 2.	0.699
CDK6	NOTCH1	ENSCJAP00000062161	ENSCJAP00000020179	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Notch receptor 1.	0.452
CDK6	STAT3	ENSCJAP00000062161	ENSCJAP00000000719	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription.	0.635
DLL1	HES5	ENSCJAP00000069799	ENSCJAP00000004630	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 5.	0.628
DLL1	NOTCH1	ENSCJAP00000069799	ENSCJAP00000020179	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.958