STRINGSTRING
SIRT4 SIRT4 CASR CASR KCNJ11 KCNJ11 SYT7 SYT7 PICK1 PICK1 VSNL1 VSNL1 EFNA5 EFNA5 NNAT NNAT JAGN1 JAGN1 NR1H4 NR1H4 DOC2B DOC2B TFAP2B TFAP2B ENSCJAP00000065650 ENSCJAP00000065650 CDV3 CDV3 TRH TRH CDV3-2 CDV3-2 NDUFAF2 NDUFAF2 CDK16 CDK16 SOX4 SOX4 PIM3 PIM3 PPP3CA PPP3CA ENSCJAP00000068405 ENSCJAP00000068405 CAPN10 CAPN10 FOXO1 FOXO1 EIPR1 EIPR1 SRI SRI ALOX5 ALOX5 KCNA5 KCNA5 ENSCJAP00000071063 ENSCJAP00000071063 ENSCJAP00000071129 ENSCJAP00000071129 PRKN PRKN IRS1 IRS1 HMGN3 HMGN3 RBP4 RBP4 SLC8B1 SLC8B1 CCL5 CCL5 PER2 PER2 SYT9 SYT9 ENSCJAP00000073312 ENSCJAP00000073312 PDX1 PDX1 GPER1 GPER1 PSMD9 PSMD9 ENSCJAP00000074997 ENSCJAP00000074997 ENSCJAP00000075133 ENSCJAP00000075133 STX4 STX4 ENSCJAP00000077629 ENSCJAP00000077629 F7GYC0_CALJA F7GYC0_CALJA UCN3 UCN3 ANO1 ANO1 GHSR GHSR BLK BLK REST REST ADCY8 ADCY8 RFX6 RFX6 SYTL4 SYTL4 CFTR CFTR CCN3 CCN3 FOXA2 FOXA2 SLC30A8 SLC30A8 GPLD1 GPLD1 ENSA ENSA ACSL4 ACSL4 MCU MCU ADCY5 ADCY5 GCK GCK GIPR GIPR ABCC8 ABCC8 NR0B2 NR0B2 ARNTL ARNTL ISL1 ISL1 SFRP1 SFRP1 C1QTNF12 C1QTNF12 STXBP4 STXBP4 NEUROD1 NEUROD1 ABCA12 ABCA12 SLC25A22 SLC25A22 UQCC2 UQCC2 PTPN11 PTPN11 SIDT2 SIDT2 HNF1A HNF1A C2CD2L C2CD2L SIRT6 SIRT6 F7B7Z6_CALJA F7B7Z6_CALJA SLC9B2 SLC9B2 LRP5 LRP5 CPT1A CPT1A HADH HADH NR1D1 NR1D1 OSBP OSBP IL1B IL1B NLGN2 NLGN2 GHRL GHRL MPC2 MPC2 ABAT ABAT PFKL PFKL LEP LEP HNF4A HNF4A BAD BAD CHGA CHGA CLOCK CLOCK RPH3AL RPH3AL HIF1A HIF1A BIRC5 BIRC5 FAM3D FAM3D LRRC8A LRRC8A GPR68 GPR68 KCNB1 KCNB1 SREBF1 SREBF1 EPHA5 EPHA5 PLA2G6 PLA2G6 GIP GIP RFX3 RFX3 IL6 IL6 PCK2 PCK2 ICA1 ICA1 PRKCE PRKCE KLF7 KLF7 PPARD PPARD TNF TNF IRS2 IRS2 MIDN MIDN FKBP1B FKBP1B CARTPT CARTPT IFNG IFNG ACVR1C ACVR1C TUNAR TUNAR G6PC2 G6PC2 TRPM4 TRPM4 INHBB INHBB FFAR1 FFAR1 TM7SF3 TM7SF3 STXBP5L STXBP5L PPP3CB PPP3CB SLC16A1 SLC16A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
CASRCalcium sensing receptor. (1089 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11 isoform 1. (390 aa)
SYT7Uncharacterized protein. (879 aa)
PICK1Protein interacting with PRKCA 1. (448 aa)
VSNL1Visinin like 1. (257 aa)
EFNA5Ephrin-A5; Belongs to the ephrin family. (228 aa)
NNATUncharacterized protein. (125 aa)
JAGN1Protein jagunal homolog 1. (183 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
TFAP2BTranscription factor AP-2 beta. (569 aa)
ENSCJAP00000065650Transcription factor 7 like 2. (649 aa)
CDV3Protein CDV3 homolog isoform b. (258 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (242 aa)
CDV3-2Uncharacterized protein. (209 aa)
NDUFAF2Uncharacterized protein. (108 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
SOX4Transcription factor SOX. (472 aa)
PIM3Pim-3 proto-oncogene, serine/threonine kinase. (596 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
ENSCJAP00000068405Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (210 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (783 aa)
FOXO1Fork-head domain-containing protein. (654 aa)
EIPR1EARP complex and GARP complex interacting protein 1. (387 aa)
SRIUncharacterized protein. (259 aa)
ALOX5Arachidonate 5-lipoxygenase. (737 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (602 aa)
ENSCJAP00000071063PFK domain-containing protein. (150 aa)
ENSCJAP00000071129Fork-head domain-containing protein. (540 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (476 aa)
IRS1Insulin receptor substrate 1. (1254 aa)
HMGN3High mobility group nucleosomal binding domain 3. (130 aa)
RBP4Retinol binding protein 4; Belongs to the calycin superfamily. Lipocalin family. (303 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (600 aa)
CCL5C-C motif chemokine. (91 aa)
PER2Period circadian regulator 2. (1309 aa)
SYT9Synaptotagmin 9. (492 aa)
ENSCJAP00000073312Uncharacterized protein. (131 aa)
PDX1Homeobox domain-containing protein. (282 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (375 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform 1. (223 aa)
ENSCJAP00000074997LSDAT_euk domain-containing protein. (136 aa)
ENSCJAP00000075133Uncharacterized protein. (332 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (414 aa)
ENSCJAP00000077629Uncharacterized protein. (150 aa)
F7GYC0_CALJAUncharacterized protein. (227 aa)
UCN3Urocortin-3 preproprotein. (161 aa)
ANO1Anoctamin. (538 aa)
GHSRGhrelin receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
BLKTyrosine-protein kinase. (464 aa)
RESTRE1 silencing transcription factor. (1076 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
RFX6Regulatory factor X6. (928 aa)
SYTL4Synaptotagmin like 4. (670 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1481 aa)
CCN3Cellular communication network factor 3. (357 aa)
FOXA2Forkhead box A2. (456 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (840 aa)
ENSAAlpha-endosulfine isoform 3; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (121 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (799 aa)
MCUCalcium uniporter protein, mitochondrial isoform 1. (350 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1261 aa)
GCKPhosphotransferase. (478 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
ABCC8ATP binding cassette subfamily C member 8. (1582 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform a. (626 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
C1QTNF12C1q and TNF related 12. (298 aa)
STXBP4Syntaxin binding protein 4. (554 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
SLC25A22Solute carrier family 25 member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
UQCC2Ubiquinol-cytochrome c reductase complex assembly factor 2. (126 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
SIDT2SID1 transmembrane family member 2. (853 aa)
HNF1AHNF1 homeobox A. (638 aa)
C2CD2LC2CD2 like. (707 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform 1. (355 aa)
F7B7Z6_CALJAUncharacterized protein. (58 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
CPT1ACarnitine O-palmitoyltransferase 1, liver isoform isoform 1; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
HADHHydroxyacyl-CoA dehydrogenase. (407 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (807 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
NLGN2Neuroligin 2. (838 aa)
GHRLAppetite-regulating hormone isoform 1 preproprotein. (117 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (542 aa)
PFKLPFK domain-containing protein. (409 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
BADBcl2 antagonist of cell death. (167 aa)
CHGAChromogranin A. (457 aa)
CLOCKCircadian locomoter output cycles protein kaput. (850 aa)
RPH3ALRabphilin 3A like (without C2 domains). (312 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
BIRC5Baculoviral IAP repeat-containing protein 5 isoform 1. (142 aa)
FAM3DFamily with sequence similarity 3 member D. (224 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1178 aa)
EPHA5Ephrin type-A receptor 5 isoform a. (1038 aa)
PLA2G6Uncharacterized protein. (836 aa)
GIPGastric inhibitory polypeptide. (153 aa)
RFX3Regulatory factor X3. (588 aa)
IL6Interleukin 6. (212 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform 1. (640 aa)
ICA1AH domain-containing protein. (509 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
KLF7Krueppel-like factor 7 isoform 1. (302 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform 1. (441 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
MIDNMidnolin. (714 aa)
FKBP1BPeptidylprolyl isomerase. (111 aa)
CARTPTCocaine-and amphetamine-regulated transcript protein preproprotein. (116 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
ACVR1CTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (579 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
G6PC2Uncharacterized protein. (80 aa)
TRPM4Uncharacterized protein. (31 aa)
INHBBInhibin subunit beta B. (407 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
STXBP5LSyntaxin binding protein 5 like. (1156 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
SLC16A1Monocarboxylate transporter 1. (500 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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