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AGTR2 AGTR2 DDAH2 DDAH2 ATP2B4 ATP2B4 DDAH1 DDAH1 NOD1 NOD1 SCARB1 SCARB1 APOE APOE HTR2B HTR2B TERF2 TERF2 IL1B IL1B LEP LEP NPR3 NPR3 HIF1A HIF1A ESR1 ESR1 PTK2B PTK2B ENG ENG NUS1 NUS1 PIK3CB PIK3CB ENSCJAP00000056213 ENSCJAP00000056213 NOS1AP NOS1AP TERT TERT ENSCJAP00000068201 ENSCJAP00000068201 GCH1 GCH1 AKT1 AKT1 APOA4 APOA4 FCER2 FCER2 ENSCJAP00000073271 ENSCJAP00000073271 ACVR2A ACVR2A EGFR EGFR CAV3 CAV3 GLA GLA ENSCJAP00000078425 ENSCJAP00000078425
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
DDAH2N(G),N(G)-dimethylarginine dimethylaminohydrolase 2. (285 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1169 aa)
DDAH1N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 1. (285 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (525 aa)
APOEApolipoprotein E. (320 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (535 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
NPR3Natriuretic peptide receptor 3. (545 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (850 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ENGEndoglin. (655 aa)
NUS1Nogo-B receptor. (293 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSCJAP00000056213Uncharacterized protein. (92 aa)
NOS1APPID domain-containing protein. (695 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (287 aa)
ENSCJAP00000068201Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (964 aa)
GCH1GTP cyclohydrolase 1 isoform 1. (250 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
APOA4Apolipoprotein A4. (400 aa)
FCER2Fc fragment of IgE receptor II. (352 aa)
ENSCJAP00000073271Uncharacterized protein. (293 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
GLAAlpha-galactosidase. (469 aa)
ENSCJAP00000078425Uncharacterized protein. (268 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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