(53 nodes) Cardiac muscle cell development network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LMNA	Uncharacterized protein; Belongs to the intermediate filament family. (677 aa)
	MYH11	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1944 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	F6PY39_CALJA	PDZ and LIM domain 5. (681 aa)
	FHL2	Four and a half LIM domains 2. (403 aa)
	SGCB	Sarcoglycan beta. (319 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	NKX2-6	NK2 homeobox 6. (301 aa)
	LRRC10B	Leucine-rich repeat-containing protein 10B. (292 aa)
	OBSL1	Obscurin like 1. (1896 aa)
	PROX1	Prospero homeobox protein 1. (737 aa)
	NEBL	Nebulette. (977 aa)
	ASB2	Ankyrin repeat and SOCS box protein 2 isoform 1. (635 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	TBX3	T-box transcription factor TBX3 isoform 2. (743 aa)
	TBX5	T-box transcription factor TBX5 isoform 1. (518 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	AKAP13	A-kinase anchoring protein 13. (2816 aa)
	ACTN2	Actinin alpha 2. (1067 aa)
	SLC8A1	Sodium/calcium exchanger 1 isoform A; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
	BVES	Blood vessel epicardial substance. (360 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	GATA4	GATA binding protein 4. (442 aa)
	TCAP	Telethonin. (167 aa)
	DCUN1D2	Uncharacterized protein. (1868 aa)
	MAP2K4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (410 aa)
	LRRC10	Leucine rich repeat containing 10. (279 aa)
	TBX18	T-box transcription factor 18. (607 aa)
	ENSCJAP00000061225	Myocyte enhancer factor 2A. (501 aa)
	ENSCJAP00000061401	Formin homology 2 domain containing 3. (1623 aa)
	ADRA1A	Adrenoceptor alpha 1A. (466 aa)
	CXADR	CXADR Ig-like cell adhesion molecule. (375 aa)
	SHOX2	Short stature homeobox 2. (319 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (1013 aa)
	HEY2	Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
	TTN	Titin. (32000 aa)
	CSRP3	Cysteine and glycine rich protein 3. (250 aa)
	SGCD	Delta-sarcoglycan isoform 1. (290 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
	ALPK3	Alpha kinase 3. (1882 aa)
	PLEC	Plectin. (6199 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	NKX2-5	NK2 homeobox 5. (324 aa)
	ENSCJAP00000075743	Uncharacterized protein. (125 aa)
	NRAP	Nebulin related anchoring protein. (1749 aa)
	ENSCJAP00000077596	Uncharacterized protein. (100 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	SORBS2	Sorbin and SH3 domain containing 2. (1594 aa)
	MYO18B	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2477 aa)
	NEB	Nebulin. (6636 aa)
	ALPK2	Alpha kinase 2. (2171 aa)
	SRF	Serum response factor. (509 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CSRP3	ENSCJAP00000025417	ENSCJAP00000069764	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.756
ACTN2	ENSCJAP00000075743	ENSCJAP00000025417	ENSCJAP00000075743	Actinin alpha 2.	Uncharacterized protein.	0.448
ACTN2	F6PY39_CALJA	ENSCJAP00000025417	ENSCJAP00000012805	Actinin alpha 2.	PDZ and LIM domain 5.	0.448
ACTN2	MYH11	ENSCJAP00000025417	ENSCJAP00000010268	Actinin alpha 2.	Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.452
ACTN2	MYO18B	ENSCJAP00000025417	ENSCJAP00000005690	Actinin alpha 2.	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.439
ACTN2	NEB	ENSCJAP00000025417	ENSCJAP00000006001	Actinin alpha 2.	Nebulin.	0.593
ACTN2	NEBL	ENSCJAP00000025417	ENSCJAP00000015196	Actinin alpha 2.	Nebulette.	0.409
ACTN2	NRAP	ENSCJAP00000025417	ENSCJAP00000076296	Actinin alpha 2.	Nebulin related anchoring protein.	0.519
ACTN2	OBSL1	ENSCJAP00000025417	ENSCJAP00000044181	Actinin alpha 2.	Obscurin like 1.	0.450
ACTN2	TCAP	ENSCJAP00000025417	ENSCJAP00000052625	Actinin alpha 2.	Telethonin.	0.805
ACTN2	TTN	ENSCJAP00000025417	ENSCJAP00000068335	Actinin alpha 2.	Titin.	0.868
ALPK3	OBSL1	ENSCJAP00000074671	ENSCJAP00000044181	Alpha kinase 3.	Obscurin like 1.	0.447
ATG5	MTOR	ENSCJAP00000011649	ENSCJAP00000004176	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.732
BMP10	BMPR1A	ENSCJAP00000035446	ENSCJAP00000050246	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.629
BMPR1A	BMP10	ENSCJAP00000050246	ENSCJAP00000035446	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.629
BVES	MYO18B	ENSCJAP00000003020	ENSCJAP00000005690	Blood vessel epicardial substance.	Myosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.719
CAV3	LRRC10	ENSCJAP00000075223	ENSCJAP00000058892	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Leucine rich repeat containing 10.	0.503
CAV3	SGCD	ENSCJAP00000075223	ENSCJAP00000072025	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Delta-sarcoglycan isoform 1.	0.489
CAV3	TTN	ENSCJAP00000075223	ENSCJAP00000068335	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Titin.	0.463
CSRP3	ACTN2	ENSCJAP00000069764	ENSCJAP00000025417	Cysteine and glycine rich protein 3.	Actinin alpha 2.	0.756