(29 nodes) Mammary gland duct morphogenesis network (Callithrix jacchus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	CSMD1	CUB and Sushi multiple domains 1. (3562 aa)
	PGR	Progesterone receptor. (935 aa)
	CSMD2	CUB and Sushi multiple domains 2. (3702 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (549 aa)
	AR	Androgen receptor. (887 aa)
	MST1	Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
	KDM5B	Lysine demethylase 5B. (1544 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	EPHA2	EPH receptor A2. (976 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
	TBX3	T-box transcription factor TBX3 isoform 2. (743 aa)
	AREG	Amphiregulin. (275 aa)
	VDR	Vitamin D receptor. (427 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	PML	Promyelocytic leukemia. (881 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (913 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	PTCH1	Protein patched homolog 1 isoform L. (1449 aa)
	SOSTDC1	CTCK domain-containing protein. (230 aa)
	NTN1	Netrin-1. (604 aa)
	FGFR2	Fibroblast growth factor receptor. (822 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	SRC	Tyrosine-protein kinase. (553 aa)
	SCRIB	Uncharacterized protein. (1686 aa)
	LRRC1	Leucine-rich repeat-containing protein 1. (524 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ESR1	ENSCJAP00000006494	ENSCJAP00000036232	Androgen receptor.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.767
AR	FGF10	ENSCJAP00000006494	ENSCJAP00000053129	Androgen receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.403
AR	MED1	ENSCJAP00000006494	ENSCJAP00000015874	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.628
AR	PGR	ENSCJAP00000006494	ENSCJAP00000001019	Androgen receptor.	Progesterone receptor.	0.680
AR	SRC	ENSCJAP00000006494	ENSCJAP00000073877	Androgen receptor.	Tyrosine-protein kinase.	0.840
AREG	CSF1R	ENSCJAP00000025471	ENSCJAP00000039242	Amphiregulin.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.668
AREG	EPHA2	ENSCJAP00000025471	ENSCJAP00000015479	Amphiregulin.	EPH receptor A2.	0.682
AREG	ESR1	ENSCJAP00000025471	ENSCJAP00000036232	Amphiregulin.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.452
AREG	PGR	ENSCJAP00000025471	ENSCJAP00000001019	Amphiregulin.	Progesterone receptor.	0.657
AREG	SRC	ENSCJAP00000025471	ENSCJAP00000073877	Amphiregulin.	Tyrosine-protein kinase.	0.516
CSF1	CSF1R	ENSCJAP00000005866	ENSCJAP00000039242	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.999
CSF1	EPHA2	ENSCJAP00000005866	ENSCJAP00000015479	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	EPH receptor A2.	0.685
CSF1	FGFR2	ENSCJAP00000005866	ENSCJAP00000065661	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Fibroblast growth factor receptor.	0.461
CSF1	SRC	ENSCJAP00000005866	ENSCJAP00000073877	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Tyrosine-protein kinase.	0.580
CSF1	TGFB1	ENSCJAP00000005866	ENSCJAP00000037471	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Transforming growth factor beta; Belongs to the TGF-beta family.	0.512
CSF1R	AREG	ENSCJAP00000039242	ENSCJAP00000025471	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Amphiregulin.	0.668
CSF1R	CSF1	ENSCJAP00000039242	ENSCJAP00000005866	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.999
CSF1R	FGF10	ENSCJAP00000039242	ENSCJAP00000053129	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.752
CSF1R	SRC	ENSCJAP00000039242	ENSCJAP00000073877	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tyrosine-protein kinase.	0.512
CSF1R	TGFB1	ENSCJAP00000039242	ENSCJAP00000037471	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.436