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BARD1 | BRCA1 associated RING domain 1. (853 aa) | ||||
BRIP1 | Uncharacterized protein. (213 aa) | ||||
TOPBP1 | DNA topoisomerase II binding protein 1. (1563 aa) | ||||
ENSCJAP00000071263 | Helicase ATP-binding domain-containing protein. (88 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa) |