(54 nodes) Demethylation network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ALKBH5	Putative alpha-ketoglutarate-dependent dioxygenase ABH5. (394 aa)
	KDM2A	Lysine demethylase 2A. (1163 aa)
	KDM2B	Lysine demethylase 2B. (1246 aa)
	FBXL19	F-box and leucine rich repeat protein 19. (694 aa)
	KDM4A	Lysine-specific demethylase 4A. (1064 aa)
	APOBEC2	Apolipoprotein B mRNA editing enzyme catalytic subunit 2. (224 aa)
	MMACHC	Methylmalonic aciduria and homocystinuria type C protein. (282 aa)
	APOBEC1	Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (221 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (876 aa)
	KDM5B	Lysine demethylase 5B. (1544 aa)
	PHF8	PHD finger protein 8. (1060 aa)
	KDM3B	Lysine-specific demethylase 3B. (1763 aa)
	KDM1B	Lysine demethylase 1B. (823 aa)
	KDM5A	Lysine demethylase 5A. (1690 aa)
	JMJD1C	Jumonji domain containing 1C. (2540 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	ALKBH2	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform 1. (261 aa)
	KDM4C	Lysine-specific demethylase 4C isoform 1. (1056 aa)
	APOBEC3H	Apolipoprotein B mRNA editing enzyme catalytic subunit 3H. (195 aa)
	POR	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (680 aa)
	KDM7A	Lysine demethylase 7A. (941 aa)
	TDG	G/T mismatch-specific thymine DNA glycosylase. (410 aa)
	KDM6B	Lysine-specific demethylase 6B. (1675 aa)
	CYP3A5	Uncharacterized protein. (503 aa)
	TET2	Tet methylcytosine dioxygenase 2. (1998 aa)
	PPME1	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (400 aa)
	HSF4	Heat shock transcription factor 4. (494 aa)
	ALKBH1	Alkylated DNA repair protein alkB homolog 1. (389 aa)
	PHF2	Lysine-specific demethylase PHF2. (1102 aa)
	KDM4B	Lysine demethylase 4B. (1130 aa)
	TET3	Tet methylcytosine dioxygenase 3. (1795 aa)
	AICDA	Activation induced cytidine deaminase. (198 aa)
	TET1	Tet methylcytosine dioxygenase 1. (2134 aa)
	KDM3A	Lysine-specific demethylase 3A. (1321 aa)
	HR	HR lysine demethylase and nuclear receptor corepressor. (1252 aa)
	F7IBW6_CALJA	Lysine demethylase 8. (416 aa)
	KDM4D	Lysine-specific demethylase 4D. (523 aa)
	ALKBH3	AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (284 aa)
	CYP2C8	Cytochrome P450 family 2 subfamily C member 8. (461 aa)
	CYP3A21	Cytochrome P450 3A21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (527 aa)
	F7DNZ2_CALJA	Uncharacterized protein. (752 aa)
	EOMES	Eomesodermin. (706 aa)
	C14orf169	Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. (631 aa)
	ENSCJAP00000054069	2OG-FeII_Oxy_2 domain-containing protein. (382 aa)
	ENSCJAP00000055709	Uncharacterized protein. (302 aa)
	PAX6	Paired box 6. (472 aa)
	KDM6A	Lysine demethylase 6A. (1429 aa)
	ALKBH4	AlkB homolog 4, lysine demethylase. (306 aa)
	JMJD6	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (414 aa)
	FTO	FTO alpha-ketoglutarate dependent dioxygenase. (559 aa)
	ENSCJAP00000068039	Cytochrome P450 3A21. (540 aa)
	KDM5C	Lysine demethylase 5C. (1601 aa)
	ENSCJAP00000074376	Uncharacterized protein. (138 aa)
	KDM4F	Lysine demethylase 4F. (457 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AICDA	TDG	ENSCJAP00000035085	ENSCJAP00000026754	Activation induced cytidine deaminase.	G/T mismatch-specific thymine DNA glycosylase.	0.599
AICDA	TET2	ENSCJAP00000035085	ENSCJAP00000028985	Activation induced cytidine deaminase.	Tet methylcytosine dioxygenase 2.	0.453
AICDA	TET3	ENSCJAP00000035085	ENSCJAP00000032958	Activation induced cytidine deaminase.	Tet methylcytosine dioxygenase 3.	0.413
ALKBH1	ALKBH2	ENSCJAP00000031165	ENSCJAP00000018663	Alkylated DNA repair protein alkB homolog 1.	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform 1.	0.645
ALKBH1	ALKBH3	ENSCJAP00000031165	ENSCJAP00000043361	Alkylated DNA repair protein alkB homolog 1.	AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase.	0.518
ALKBH1	ALKBH4	ENSCJAP00000031165	ENSCJAP00000060615	Alkylated DNA repair protein alkB homolog 1.	AlkB homolog 4, lysine demethylase.	0.649
ALKBH1	ALKBH5	ENSCJAP00000031165	ENSCJAP00000001667	Alkylated DNA repair protein alkB homolog 1.	Putative alpha-ketoglutarate-dependent dioxygenase ABH5.	0.516
ALKBH1	ENSCJAP00000054069	ENSCJAP00000031165	ENSCJAP00000054069	Alkylated DNA repair protein alkB homolog 1.	2OG-FeII_Oxy_2 domain-containing protein.	0.516
ALKBH1	FTO	ENSCJAP00000031165	ENSCJAP00000065416	Alkylated DNA repair protein alkB homolog 1.	FTO alpha-ketoglutarate dependent dioxygenase.	0.795
ALKBH2	ALKBH1	ENSCJAP00000018663	ENSCJAP00000031165	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform 1.	Alkylated DNA repair protein alkB homolog 1.	0.645
ALKBH2	ALKBH4	ENSCJAP00000018663	ENSCJAP00000060615	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform 1.	AlkB homolog 4, lysine demethylase.	0.535
ALKBH2	FTO	ENSCJAP00000018663	ENSCJAP00000065416	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform 1.	FTO alpha-ketoglutarate dependent dioxygenase.	0.465
ALKBH3	ALKBH1	ENSCJAP00000043361	ENSCJAP00000031165	AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase.	Alkylated DNA repair protein alkB homolog 1.	0.518
ALKBH4	ALKBH1	ENSCJAP00000060615	ENSCJAP00000031165	AlkB homolog 4, lysine demethylase.	Alkylated DNA repair protein alkB homolog 1.	0.649
ALKBH4	ALKBH2	ENSCJAP00000060615	ENSCJAP00000018663	AlkB homolog 4, lysine demethylase.	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 isoform 1.	0.535
ALKBH4	APEX1	ENSCJAP00000060615	ENSCJAP00000017864	AlkB homolog 4, lysine demethylase.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.598
ALKBH5	ALKBH1	ENSCJAP00000001667	ENSCJAP00000031165	Putative alpha-ketoglutarate-dependent dioxygenase ABH5.	Alkylated DNA repair protein alkB homolog 1.	0.516
ALKBH5	FTO	ENSCJAP00000001667	ENSCJAP00000065416	Putative alpha-ketoglutarate-dependent dioxygenase ABH5.	FTO alpha-ketoglutarate dependent dioxygenase.	0.929
APEX1	ALKBH4	ENSCJAP00000017864	ENSCJAP00000060615	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	AlkB homolog 4, lysine demethylase.	0.598
APEX1	TDG	ENSCJAP00000017864	ENSCJAP00000026754	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	G/T mismatch-specific thymine DNA glycosylase.	0.796