(91 nodes) Cellular response to interferon-gamma network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAB43	RAB43, member RAS oncogene family. (212 aa)
	SP100	SP100 nuclear antigen. (880 aa)
	IRF1	Interferon regulatory factor. (324 aa)
	ENSCJAP00000060083	Uncharacterized protein. (748 aa)
	GSN	Gelsolin isoform a. (782 aa)
	XCL1	SCY domain-containing protein. (114 aa)
	VPS26B	VPS26, retromer complex component B. (325 aa)
	CCL14	C-C motif chemokine. (116 aa)
	ENSCJAP00000064616	Glyceraldehyde-3-phosphate dehydrogenase. (328 aa)
	ENSCJAP00000064935	annotation not available (335 aa)
	FLNB	Filamin-B isoform 1. (2633 aa)
	ENSCJAP00000066250	Glyceraldehyde-3-phosphate dehydrogenase. (357 aa)
	ENSCJAP00000066473	SCY domain-containing protein. (88 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	CCL17	C-C motif chemokine. (148 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (429 aa)
	ENSCJAP00000069011	GB1/RHD3-type G domain-containing protein. (148 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1157 aa)
	TDGF1	Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (186 aa)
	CCL25	SCY domain-containing protein. (275 aa)
	ENSCJAP00000072057	Uncharacterized protein. (170 aa)
	ENSCJAP00000072171	Uncharacterized protein. (145 aa)
	ENSCJAP00000072244	SCY domain-containing protein. (108 aa)
	CCL19	C-C motif chemokine. (104 aa)
	CCL5	C-C motif chemokine. (91 aa)
	ENSCJAP00000073867	Uncharacterized protein. (149 aa)
	IFNGR1	Interferon gamma receptor 1. (475 aa)
	FCAR	Fc fragment of IgA receptor. (285 aa)
	ENSCJAP00000075496	C-C motif chemokine. (137 aa)
	ENSCJAP00000075963	CFC domain-containing protein. (176 aa)
	RAB20	Uncharacterized protein. (396 aa)
	GBP6	Guanylate binding protein family member 6. (633 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
	STX8	Syntaxin 8. (245 aa)
	CAJA-DPA1	MHC class II protein; Belongs to the MHC class II family. (260 aa)
	ENSCJAP00000076923	GB1/RHD3-type G domain-containing protein. (148 aa)
	LOC100405150	GB1/RHD3-type G domain-containing protein. (605 aa)
	CCL2	C-C motif chemokine. (98 aa)
	RAB7B	Uncharacterized protein. (382 aa)
	ENSCJAP00000077552	Uncharacterized protein; Belongs to the actin family. (213 aa)
	CCL1	SCY domain-containing protein. (103 aa)
	EPRS1	Uncharacterized protein. (1537 aa)
	STX4	Syntaxin 4; Belongs to the syntaxin family. (414 aa)
	LOC100406244	GB1/RHD3-type G domain-containing protein. (632 aa)
	GBP2	Guanylate binding protein 2. (596 aa)
	GBP3	Guanylate binding protein 3. (597 aa)
	MYO1C	Unconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
	WAS	WASP actin nucleation promoting factor. (502 aa)
	STXBP3	Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
	NMI	N-myc and STAT interactor. (328 aa)
	SLC26A6	Solute carrier family 26 member 6. (758 aa)
	SYNCRIP	Synaptotagmin binding cytoplasmic RNA interacting protein. (623 aa)
	DAPK1	Death-associated protein kinase 1. (1430 aa)
	STAT1	Signal transducer and activator of transcription. (791 aa)
	CD58	Lymphocyte function-associated antigen 3 isoform 1. (252 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	F7EMI9_CALJA	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	MRC1	Mannose receptor C-type 1. (1454 aa)
	CCL21	C-C motif chemokine ligand 21. (134 aa)
	ZYX	Zyxin. (570 aa)
	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif 13. (1486 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (426 aa)
	STXBP4	Syntaxin binding protein 4. (554 aa)
	CCL20	C-C motif chemokine. (96 aa)
	KIF5B	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (963 aa)
	ACTR3	Uncharacterized protein; Belongs to the actin family. (428 aa)
	HPX	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (459 aa)
	DAPK3	Death associated protein kinase 3; Belongs to the protein kinase superfamily. (455 aa)
	CCL16	C-C motif chemokine. (135 aa)
	LOC100415219	C-C motif chemokine. (93 aa)
	JAK1	Tyrosine-protein kinase. (1154 aa)
	CCL24	C-C motif chemokine ligand 24. (119 aa)
	IRF8	Interferon regulatory factor 8. (426 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (328 aa)
	PDE12	2',5'-phosphodiesterase 12. (608 aa)
	ASS1	Argininosuccinate synthase 1. (412 aa)
	AQP4	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (358 aa)
	SIRPA	Tyrosine-protein phosphatase non-receptor type substrate 1. (510 aa)
	F7H580_CALJA	Glyceraldehyde-3-phosphate dehydrogenase. (319 aa)
	ACOD1	Aconitate decarboxylase 1. (487 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (466 aa)
	F7I1B4_CALJA	CARD domain-containing protein. (106 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	ACTR3B	Uncharacterized protein; Belongs to the actin family. (430 aa)
	IFNGR2	Interferon gamma receptor 2. (338 aa)
	ENSCJAP00000053284	Glyceraldehyde-3-phosphate dehydrogenase. (332 aa)
	CCL8	C-C motif chemokine ligand 8. (99 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	LOC100385441	SCY domain-containing protein. (103 aa)
	IL12RB1	Interleukin 12 receptor subunit beta 1. (663 aa)
	CDC42EP2	Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (210 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTR3	ACTR3B	ENSCJAP00000025976	ENSCJAP00000052521	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.944
ACTR3	MYO1C	ENSCJAP00000025976	ENSCJAP00000003776	Uncharacterized protein; Belongs to the actin family.	Unconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.514
ACTR3	WAS	ENSCJAP00000025976	ENSCJAP00000004280	Uncharacterized protein; Belongs to the actin family.	WASP actin nucleation promoting factor.	0.829
ACTR3B	ACTR3	ENSCJAP00000052521	ENSCJAP00000025976	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.944
ACTR3B	ENSCJAP00000077552	ENSCJAP00000052521	ENSCJAP00000077552	Uncharacterized protein; Belongs to the actin family.	Uncharacterized protein; Belongs to the actin family.	0.467
ACTR3B	MYO1C	ENSCJAP00000052521	ENSCJAP00000003776	Uncharacterized protein; Belongs to the actin family.	Unconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.502
ACTR3B	WAS	ENSCJAP00000052521	ENSCJAP00000004280	Uncharacterized protein; Belongs to the actin family.	WASP actin nucleation promoting factor.	0.807
AQP4	VIM	ENSCJAP00000038580	ENSCJAP00000045438	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Vimentin; Belongs to the intermediate filament family.	0.422
ASS1	EPRS1	ENSCJAP00000038228	ENSCJAP00000079038	Argininosuccinate synthase 1.	Uncharacterized protein.	0.479
CASP1	CCL2	ENSCJAP00000018093	ENSCJAP00000077107	Uncharacterized protein; Belongs to the peptidase C14A family.	C-C motif chemokine.	0.537
CASP1	CCL5	ENSCJAP00000018093	ENSCJAP00000072650	Uncharacterized protein; Belongs to the peptidase C14A family.	C-C motif chemokine.	0.443
CASP1	IFNG	ENSCJAP00000018093	ENSCJAP00000056963	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.711
CASP1	IRF1	ENSCJAP00000018093	ENSCJAP00000059836	Uncharacterized protein; Belongs to the peptidase C14A family.	Interferon regulatory factor.	0.489
CASP1	STAT1	ENSCJAP00000018093	ENSCJAP00000010811	Uncharacterized protein; Belongs to the peptidase C14A family.	Signal transducer and activator of transcription.	0.485
CASP1	TLR3	ENSCJAP00000018093	ENSCJAP00000076329	Uncharacterized protein; Belongs to the peptidase C14A family.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.614
CCL1	CCL16	ENSCJAP00000078154	ENSCJAP00000027728	SCY domain-containing protein.	C-C motif chemokine.	0.679
CCL1	CCL17	ENSCJAP00000078154	ENSCJAP00000068577	SCY domain-containing protein.	C-C motif chemokine.	0.733
CCL1	CCL19	ENSCJAP00000078154	ENSCJAP00000072526	SCY domain-containing protein.	C-C motif chemokine.	0.470
CCL1	CCL2	ENSCJAP00000078154	ENSCJAP00000077107	SCY domain-containing protein.	C-C motif chemokine.	0.589
CCL1	CCL20	ENSCJAP00000078154	ENSCJAP00000023952	SCY domain-containing protein.	C-C motif chemokine.	0.536