STRINGSTRING
HOXA11 HOXA11 GZF1 GZF1 IRX3 IRX3 SALL1 SALL1 HES5 HES5 SOX8 SOX8 GPC3 GPC3 WT1 WT1 KLHL3 KLHL3 LGR4 LGR4 PKD2 PKD2 GREB1 GREB1 HS2ST1 HS2ST1 OSR1 OSR1 TMEM59L TMEM59L GLI3 GLI3 GDNF GDNF SMO SMO WNT6 WNT6 WNK4 WNK4 DLG1 DLG1 WNT11 WNT11 KIF26B KIF26B FGF8 FGF8 CTNNB1 CTNNB1 SHH SHH PGF PGF WNT1 WNT1 FGF1 FGF1 EYA1 EYA1 GATA3 GATA3 NOG NOG SIX1 SIX1 LZTS2 LZTS2 HOXD11 HOXD11 SMAD4 SMAD4 COMMD5 COMMD5 PTCH1 PTCH1 TACSTD2 TACSTD2 HS3ST3A1 HS3ST3A1 BCL2 BCL2 PAX2 PAX2 DSPP DSPP IRX1 IRX1 HS3ST3B1 HS3ST3B1 CTNNBIP1 CTNNBIP1 WNT4 WNT4 SOX9 SOX9 TCF21 TCF21 IRX2 IRX2 ERBB4 ERBB4 BMP4 BMP4 BMP7 BMP7 LHX1 LHX1 AHI1 AHI1 SIX2 SIX2 ADAMTS16 ADAMTS16 PDGFRB PDGFRB BMP2 BMP2 FGF2 FGF2 FOXD1 FOXD1 GREB1L GREB1L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXA11Homeobox protein Hox-A11. (314 aa)
GZF1GDNF-inducible zinc finger protein 1. (709 aa)
IRX3Iroquois homeobox 3. (501 aa)
SALL1Spalt like transcription factor 1. (1322 aa)
HES5Hes family bHLH transcription factor 5. (162 aa)
SOX8SRY-box transcription factor 8. (538 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
WT1WT1 transcription factor. (522 aa)
KLHL3Kelch like family member 3. (608 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (973 aa)
GREB1Growth regulating estrogen receptor binding 1. (1952 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1 isoform 1. (356 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
TMEM59LTransmembrane protein 59 like. (338 aa)
GLI3GLI family zinc finger 3. (1578 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNK4WNK lysine deficient protein kinase 4. (1232 aa)
DLG1Uncharacterized protein; Belongs to the MAGUK family. (938 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (476 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1985 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CTNNB1Catenin beta 1. (774 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (225 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (643 aa)
GATA3GATA binding protein 3. (444 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SIX1Homeobox protein SIX1. (284 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
HOXD11Homeobox D11. (338 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
COMMD5COMM domain containing 5. (224 aa)
PTCH1Protein patched homolog 1 isoform L. (1449 aa)
TACSTD2Tumor associated calcium signal transducer 2. (320 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
PAX2Paired box 2. (448 aa)
DSPPDentin sialophosphoprotein. (1080 aa)
IRX1Iroquois homeobox 1. (480 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
TCF21Transcription factor 21. (179 aa)
IRX2Iroquois homeobox 2. (501 aa)
ERBB4Receptor protein-tyrosine kinase. (1331 aa)
BMP4Bone morphogenetic protein 4 preproprotein. (408 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
LHX1LIM homeobox 1. (456 aa)
AHI1Abelson helper integration site 1. (1227 aa)
SIX2Homeobox protein SIX2. (291 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1259 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
BMP2Bone morphogenetic protein 2. (401 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
FOXD1Forkhead box D1. (474 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.