(17 nodes) Kidney mesenchyme development network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	PAX2	Paired box 2. (448 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
	TCF21	Transcription factor 21. (179 aa)
	BMP4	Bone morphogenetic protein 4 preproprotein. (408 aa)
	BMP7	Bone morphogenetic protein 7. (430 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
	SIX2	Homeobox protein SIX2. (291 aa)
	FOXD1	Forkhead box D1. (474 aa)
	STAT1	Signal transducer and activator of transcription. (791 aa)
	WT1	WT1 transcription factor. (522 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (973 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	AMER1	APC membrane recruitment protein 1. (1134 aa)
	SIX4	SIX homeobox 4. (781 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	SIX1	Homeobox protein SIX1. (284 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMER1	WT1	ENSCJAP00000032929	ENSCJAP00000010882	APC membrane recruitment protein 1.	WT1 transcription factor.	0.501
BMP4	BMP7	ENSCJAP00000070142	ENSCJAP00000070399	Bone morphogenetic protein 4 preproprotein.	Bone morphogenetic protein 7.	0.824
BMP4	SHH	ENSCJAP00000070142	ENSCJAP00000037954	Bone morphogenetic protein 4 preproprotein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.736
BMP4	SIX2	ENSCJAP00000070142	ENSCJAP00000072397	Bone morphogenetic protein 4 preproprotein.	Homeobox protein SIX2.	0.414
BMP4	SMAD4	ENSCJAP00000070142	ENSCJAP00000056533	Bone morphogenetic protein 4 preproprotein.	Mothers against decapentaplegic homolog.	0.919
BMP7	BMP4	ENSCJAP00000070399	ENSCJAP00000070142	Bone morphogenetic protein 7.	Bone morphogenetic protein 4 preproprotein.	0.824
BMP7	SHH	ENSCJAP00000070399	ENSCJAP00000037954	Bone morphogenetic protein 7.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.504
BMP7	SMAD4	ENSCJAP00000070399	ENSCJAP00000056533	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.592
BMP7	WNT4	ENSCJAP00000070399	ENSCJAP00000067759	Bone morphogenetic protein 7.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.467
BMP7	WT1	ENSCJAP00000070399	ENSCJAP00000010882	Bone morphogenetic protein 7.	WT1 transcription factor.	0.490
FOXD1	SMAD4	ENSCJAP00000078199	ENSCJAP00000056533	Forkhead box D1.	Mothers against decapentaplegic homolog.	0.418
FOXD1	WT1	ENSCJAP00000078199	ENSCJAP00000010882	Forkhead box D1.	WT1 transcription factor.	0.415
OSR1	SIX2	ENSCJAP00000013731	ENSCJAP00000072397	Odd-skipped related transcription factor 1.	Homeobox protein SIX2.	0.453
PAX2	SHH	ENSCJAP00000066740	ENSCJAP00000037954	Paired box 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.424
PAX2	SIX1	ENSCJAP00000066740	ENSCJAP00000053864	Paired box 2.	Homeobox protein SIX1.	0.662
PAX2	SIX2	ENSCJAP00000066740	ENSCJAP00000072397	Paired box 2.	Homeobox protein SIX2.	0.659
PAX2	SIX4	ENSCJAP00000066740	ENSCJAP00000035525	Paired box 2.	SIX homeobox 4.	0.420
PAX2	WNT4	ENSCJAP00000066740	ENSCJAP00000067759	Paired box 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.434
PAX2	WT1	ENSCJAP00000066740	ENSCJAP00000010882	Paired box 2.	WT1 transcription factor.	0.662
PDGFRB	STAT1	ENSCJAP00000072743	ENSCJAP00000010811	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	Signal transducer and activator of transcription.	0.513