STRINGSTRING
SOX9 SOX9 HAND2 HAND2 BMP4 BMP4 MKS1 MKS1 SMAD4 SMAD4 EYA1 EYA1 BMP10 BMP10 CTNNB1 CTNNB1 NOTCH1 NOTCH1 ISL1 ISL1 TBX5 TBX5 TBX3 TBX3 PIM1 PIM1 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
BMP4Bone morphogenetic protein 4 preproprotein. (408 aa)
MKS1Meckel syndrome type 1 protein isoform 1. (559 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (643 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
CTNNB1Catenin beta 1. (774 aa)
NOTCH1Notch receptor 1. (2551 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
TBX5T-box transcription factor TBX5 isoform 1. (518 aa)
TBX3T-box transcription factor TBX3 isoform 2. (743 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.