(51 nodes) Negative regulation of signaling receptor activity network (Callithrix jacchus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CNRIP1	Cannabinoid receptor interacting protein 1. (164 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (462 aa)
	SLC6A9	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (664 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	ENSCJAP00000067845	UPAR/Ly6 domain-containing protein. (138 aa)
	IL1RN	Interleukin-1. (165 aa)
	PXDN	Uncharacterized protein. (691 aa)
	SLURP2	Secreted LY6/PLAUR domain containing 2. (95 aa)
	LYPD6B	LY6/PLAUR domain containing 6B. (206 aa)
	ZFYVE28	Zinc finger FYVE-type containing 28. (687 aa)
	FAM72A	Uncharacterized protein. (149 aa)
	FST	Follistatin isoform FST344. (344 aa)
	CBLB	Cbl proto-oncogene B. (992 aa)
	IGSF1	Immunoglobulin superfamily member 1. (1341 aa)
	TNF	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (388 aa)
	CALCR	G_PROTEIN_RECEP_F2_3 domain-containing protein. (162 aa)
	F6SZI7_CALJA	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (461 aa)
	SPINT3	Serine peptidase inhibitor, Kunitz type 3. (89 aa)
	GPRC5A	G protein-coupled receptor class C group 5 member A. (357 aa)
	LY6H	UPAR/Ly6 domain-containing protein. (326 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (576 aa)
	SOCS4	Suppressor of cytokine signaling 4. (440 aa)
	IL18BP	Interleukin-18-binding protein isoform c. (198 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1183 aa)
	ADH7	Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide. (385 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
	LYPD1	Ly6/PLAUR domain-containing protein 1 isoform a. (141 aa)
	CBL	E3 ubiquitin-protein ligase CBL. (909 aa)
	IL36RN	Interleukin-1. (155 aa)
	VPS25	Vacuolar protein-sorting-associated protein 25. (176 aa)
	LRPAP1	Alpha-2-macroglobulin receptor-associated protein. (358 aa)
	CBLC	Cbl proto-oncogene C. (454 aa)
	WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (554 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (205 aa)
	ZGPAT	Zinc finger CCCH-type with G patch domain-containing protein isoform c. (501 aa)
	DKK4	Dickkopf WNT signaling pathway inhibitor 4. (224 aa)
	EPHB2	EPH receptor B2. (987 aa)
	CHMP6	Charged multivesicular body protein 6. (201 aa)
	LY6G6D	Uncharacterized protein. (174 aa)
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha. (468 aa)
	DKKL1	Dickkopf like acrosomal protein 1. (242 aa)
	ENSCJAP00000078071	MHC_I-like_Ag-recog domain-containing protein; Belongs to the MHC class I family. (389 aa)
	DKK1	Dickkopf_N domain-containing protein. (332 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (690 aa)
	LYPD6	Ly6/PLAUR domain-containing protein 6. (171 aa)
	DKK2	Dickkopf_N domain-containing protein. (259 aa)
	RAMP3	Receptor activity-modifying protein 3. (148 aa)
	ACE2	Angiotensin I converting enzyme 2. (844 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	AGTR2	ENSCJAP00000073088	ENSCJAP00000004568	Angiotensin I converting enzyme 2.	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.720
ACE2	PXDN	ENSCJAP00000073088	ENSCJAP00000071540	Angiotensin I converting enzyme 2.	Uncharacterized protein.	0.462
ACE2	TNF	ENSCJAP00000073088	ENSCJAP00000053053	Angiotensin I converting enzyme 2.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.627
AGTR2	ACE2	ENSCJAP00000004568	ENSCJAP00000073088	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	Angiotensin I converting enzyme 2.	0.720
CALCR	RAMP3	ENSCJAP00000048945	ENSCJAP00000074758	G_PROTEIN_RECEP_F2_3 domain-containing protein.	Receptor activity-modifying protein 3.	0.970
CBL	CBLB	ENSCJAP00000025794	ENSCJAP00000056567	E3 ubiquitin-protein ligase CBL.	Cbl proto-oncogene B.	0.923
CBL	CBLC	ENSCJAP00000025794	ENSCJAP00000024137	E3 ubiquitin-protein ligase CBL.	Cbl proto-oncogene C.	0.907
CBLB	CBL	ENSCJAP00000056567	ENSCJAP00000025794	Cbl proto-oncogene B.	E3 ubiquitin-protein ligase CBL.	0.923
CBLB	CBLC	ENSCJAP00000056567	ENSCJAP00000024137	Cbl proto-oncogene B.	Cbl proto-oncogene C.	0.909
CBLC	CBL	ENSCJAP00000024137	ENSCJAP00000025794	Cbl proto-oncogene C.	E3 ubiquitin-protein ligase CBL.	0.907
CBLC	CBLB	ENSCJAP00000024137	ENSCJAP00000056567	Cbl proto-oncogene C.	Cbl proto-oncogene B.	0.909
CHMP6	VPS25	ENSCJAP00000005941	ENSCJAP00000024397	Charged multivesicular body protein 6.	Vacuolar protein-sorting-associated protein 25.	0.996
DKK1	DKK2	ENSCJAP00000076557	ENSCJAP00000074894	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.962
DKK1	DKK3	ENSCJAP00000076557	ENSCJAP00000049622	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 3.	0.759
DKK1	DKK4	ENSCJAP00000076557	ENSCJAP00000014770	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 4.	0.949
DKK1	DKKL1	ENSCJAP00000076557	ENSCJAP00000000174	Dickkopf_N domain-containing protein.	Dickkopf like acrosomal protein 1.	0.529
DKK2	DKK1	ENSCJAP00000074894	ENSCJAP00000076557	Dickkopf_N domain-containing protein.	Dickkopf_N domain-containing protein.	0.962
DKK2	DKK3	ENSCJAP00000074894	ENSCJAP00000049622	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 3.	0.824
DKK2	DKK4	ENSCJAP00000074894	ENSCJAP00000014770	Dickkopf_N domain-containing protein.	Dickkopf WNT signaling pathway inhibitor 4.	0.932
DKK2	DKKL1	ENSCJAP00000074894	ENSCJAP00000000174	Dickkopf_N domain-containing protein.	Dickkopf like acrosomal protein 1.	0.581