(23 nodes) BRCT domain superfamily network (Callithrix jacchus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	LIG3	DNA ligase. (1014 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
	XRCC1	X-ray repair cross complementing 1. (633 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1563 aa)
	ECT2	Epithelial cell transforming 2. (927 aa)
	REV1	REV1 DNA directed polymerase. (730 aa)
	RFC1	Replication factor C subunit 1. (1147 aa)
	POLM	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (510 aa)
	TERF2IP	Telomeric repeat-binding factor 2-interacting protein 1. (399 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (971 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1040 aa)
	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1105 aa)
	SLF1	Ankyrin repeat domain-containing protein 32. (1059 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1971 aa)
	PAXIP1	PAX interacting protein 1. (1053 aa)
	MCPH1	Microcephalin isoform 1. (840 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (588 aa)
	BARD1	BRCA1 associated RING domain 1. (853 aa)
	SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa)
	MDC1	Mediator of DNA damage checkpoint 1. (2172 aa)
	LIG4	DNA ligase. (911 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSCJAP00000021140	ENSCJAP00000023883	BRCA1 associated RING domain 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.999
BARD1	LIG3	ENSCJAP00000021140	ENSCJAP00000057467	BRCA1 associated RING domain 1.	DNA ligase.	0.427
BARD1	LIG4	ENSCJAP00000021140	ENSCJAP00000048625	BRCA1 associated RING domain 1.	DNA ligase.	0.407
BARD1	MDC1	ENSCJAP00000021140	ENSCJAP00000045692	BRCA1 associated RING domain 1.	Mediator of DNA damage checkpoint 1.	0.900
BARD1	NBN	ENSCJAP00000021140	ENSCJAP00000075636	BRCA1 associated RING domain 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.953
BARD1	PARP1	ENSCJAP00000021140	ENSCJAP00000072405	BRCA1 associated RING domain 1.	Poly [ADP-ribose] polymerase.	0.458
BARD1	PAXIP1	ENSCJAP00000021140	ENSCJAP00000000270	BRCA1 associated RING domain 1.	PAX interacting protein 1.	0.882
BARD1	PES1	ENSCJAP00000021140	ENSCJAP00000019595	BRCA1 associated RING domain 1.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.	0.517
BARD1	RFC1	ENSCJAP00000021140	ENSCJAP00000038500	BRCA1 associated RING domain 1.	Replication factor C subunit 1.	0.633
BARD1	SLF1	ENSCJAP00000021140	ENSCJAP00000019184	BRCA1 associated RING domain 1.	Ankyrin repeat domain-containing protein 32.	0.989
BARD1	TOPBP1	ENSCJAP00000021140	ENSCJAP00000077630	BRCA1 associated RING domain 1.	DNA topoisomerase II binding protein 1.	0.991
BARD1	TP53BP1	ENSCJAP00000021140	ENSCJAP00000045523	BRCA1 associated RING domain 1.	Tumor protein p53 binding protein 1.	0.901
BRCA1	BARD1	ENSCJAP00000023883	ENSCJAP00000021140	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1 associated RING domain 1.	0.999
BRCA1	CTDP1	ENSCJAP00000023883	ENSCJAP00000065789	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	0.470
BRCA1	ECT2	ENSCJAP00000023883	ENSCJAP00000079063	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Epithelial cell transforming 2.	0.424
BRCA1	LIG4	ENSCJAP00000023883	ENSCJAP00000048625	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA ligase.	0.811
BRCA1	MDC1	ENSCJAP00000023883	ENSCJAP00000045692	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Mediator of DNA damage checkpoint 1.	0.970
BRCA1	NBN	ENSCJAP00000023883	ENSCJAP00000075636	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.899
BRCA1	PARP1	ENSCJAP00000023883	ENSCJAP00000072405	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Poly [ADP-ribose] polymerase.	0.823
BRCA1	PAXIP1	ENSCJAP00000023883	ENSCJAP00000000270	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	PAX interacting protein 1.	0.806