STRINGSTRING
CD80 CD80 ENSCJAP00000078416 ENSCJAP00000078416 PPP4R1 PPP4R1 BTC BTC FGF2 FGF2 STRN4 STRN4 BANK1 BANK1 FGF7 FGF7 FGF9 FGF9 EGFR EGFR FGF18 FGF18 SRC SRC CALCB CALCB FGFR1 FGFR1 ENSCJAP00000072746 ENSCJAP00000072746 PDGFRB PDGFRB PIP5K1C PIP5K1C ENSCJAP00000071975 ENSCJAP00000071975 IRS1 IRS1 AKT1 AKT1 CD19 CD19 FGF23 FGF23 ERBB4 ERBB4 ICOS ICOS CD28 CD28 GRB2 GRB2 EPGN-2 EPGN-2 RELCH RELCH FGFR2 FGFR2 PIP5K1B PIP5K1B PIP4K2B PIP4K2B EREG EREG PDGFB PDGFB PPP4R4 PPP4R4 IER3 IER3 IL33 IL33 NRG3 NRG3 FGFR3 FGFR3 FGF16 FGF16 MAPK3 MAPK3 PIK3AP1 PIK3AP1 F7GTV7_CALJA F7GTV7_CALJA ENSCJAP00000056577 ENSCJAP00000056577 HBEGF HBEGF PTEN PTEN KIT KIT PPP2R1B PPP2R1B IRS2 IRS2 RHOG RHOG INSR INSR FGF10 FGF10 PIK3CB PIK3CB PPP2CA PPP2CA FGF5 FGF5 TRAT1 TRAT1 PPP2R5C PPP2R5C EPGN EPGN FRS2 FRS2 NRG2 NRG2 MAPK1 MAPK1 FGF1 FGF1 VAV1 VAV1 PIK3R3 PIK3R3 TRIB3 TRIB3 FGF17 FGF17 FNBP4 FNBP4 FAM102A FAM102A PIP5KL1 PIP5KL1 KITLG KITLG ESR2 ESR2 ESR1 ESR1 FLT3 FLT3 TGFA TGFA PDGFRA PDGFRA KL KL INS INS FGF19 FGF19 CD276 CD276 LRRC40 LRRC40 FGF8 FGF8 WDR64 WDR64 AKT3 AKT3 SPEM1 SPEM1 SPEM2 SPEM2 PIK3R1 PIK3R1 PPP2R5A PPP2R5A PHLPP2 PHLPP2 NARS2 NARS2 AKT2 AKT2 IRAK1 IRAK1 FGF4 FGF4 IL1RAP IL1RAP PIK3R2 PIK3R2 AREG AREG IRAK4 IRAK4 PIK3CA PIK3CA FGF22 FGF22 PTPN11 PTPN11 PPP2CB PPP2CB NRG4 NRG4 ERBB3 ERBB3 FGF20 FGF20 TRAF6 TRAF6 PPP2R1A PPP2R1A MYD88 MYD88 FGF3 FGF3 FNDC3A FNDC3A IL1RL1 IL1RL1 CD86 CD86 PIP4K2A PIP4K2A NRG1 NRG1 THEM4 THEM4 PIP5K1A PIP5K1A FGFR4 FGFR4 PIP4K2C PIP4K2C STRN3 STRN3 MET MET PDGFA PDGFA FYN FYN PPP2R5D PPP2R5D EGF EGF STRN STRN HGF HGF PHLPP1 PHLPP1 GAB1 GAB1 PPP2R5B PPP2R5B FAM102B FAM102B FNDC3B FNDC3B PPP2R5E PPP2R5E FGF6 FGF6 ERBB2 ERBB2 LCK LCK KLB KLB PIK3CD PIK3CD FLT3LG FLT3LG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD80Uncharacterized protein. (348 aa)
ENSCJAP00000078416Uncharacterized protein. (918 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (984 aa)
BTCProbetacellulin. (178 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
STRN4Striatin 4. (743 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (796 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (332 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF18Uncharacterized protein; Belongs to the heparin-binding growth factors family. (378 aa)
SRCTyrosine-protein kinase. (553 aa)
CALCBINSC_LBD domain-containing protein. (593 aa)
FGFR1Fibroblast growth factor receptor. (885 aa)
ENSCJAP00000072746Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (454 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
ENSCJAP00000071975Uncharacterized protein. (341 aa)
IRS1Insulin receptor substrate 1. (1254 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
CD19B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] (623 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (300 aa)
ERBB4Receptor protein-tyrosine kinase. (1331 aa)
ICOSInducible T cell costimulator. (211 aa)
CD28IGv domain-containing protein. (234 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
EPGN-2Epithelial mitogen. (187 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1253 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (555 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
EREGEpiregulin. (169 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 1. (873 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (156 aa)
IL33Interleukin 33. (270 aa)
NRG3Neuregulin 3. (720 aa)
FGFR3Fibroblast growth factor receptor. (810 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (805 aa)
F7GTV7_CALJAUncharacterized protein. (151 aa)
ENSCJAP00000056577Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (277 aa)
HBEGFHeparin binding EGF like growth factor. (218 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (976 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (765 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1; Belongs to the PI3/PI4-kinase family. (1070 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (186 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (555 aa)
EPGNEGF-like domain-containing protein. (187 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
NRG2Neuregulin 2. (847 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FNBP4Formin-binding protein 4. (1019 aa)
FAM102AFamily with sequence similarity 102 member A. (384 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (454 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (530 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
TGFATransforming growth factor alpha. (165 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KLKlotho. (1012 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
CD276CD276 molecule. (534 aa)
LRRC40Leucine-rich repeat-containing protein 40. (602 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
WDR64WD repeat domain 64. (1121 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
SPEM1Spermatid maturation 1. (308 aa)
SPEM2SPEM family member 2. (496 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1. (724 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PHLPP2PPM-type phosphatase domain-containing protein. (1357 aa)
NARS2GRB2-associated-binding protein 2 isoform a. (676 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
IRAK1Interleukin-1 receptor-associated kinase 1 isoform 1 (Predicted). (712 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform 3. (687 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
AREGAmphiregulin. (275 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform a. (460 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
NRG4Neuregulin 4. (115 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3 isoform 1. (1341 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (537 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform 1. (1198 aa)
IL1RL1Interleukin 1 receptor like 1. (557 aa)
CD86Ig-like domain-containing protein. (361 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (406 aa)
NRG1Neuregulin 1. (713 aa)
THEM4Thioesterase superfamily member 4. (238 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2. (550 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a. (421 aa)
STRN3Striatin-3 isoform 1. (797 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1353 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (443 aa)
FYNTyrosine-protein kinase. (537 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (600 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
STRNStriatin. (780 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (813 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1710 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (646 aa)
FAM102BFamily with sequence similarity 102 member B. (360 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1204 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LCKTyrosine-protein kinase. (539 aa)
KLBKlotho beta. (1045 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (224 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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