STRINGSTRING
ENSCJAP00000071263 ENSCJAP00000071263 HDAC1 HDAC1 PIP4P2 PIP4P2 ENSCJAP00000078920 ENSCJAP00000078920 TAF4 TAF4 KAT5 KAT5 BRIP1 BRIP1 TOPBP1 TOPBP1 ENSCJAP00000077446 ENSCJAP00000077446 ENSCJAP00000077268 ENSCJAP00000077268 EHMT1 EHMT1 NUAK1 NUAK1 ENSCJAP00000076896 ENSCJAP00000076896 ENSCJAP00000075918 ENSCJAP00000075918 ENSCJAP00000075765 ENSCJAP00000075765 ENSCJAP00000075742 ENSCJAP00000075742 NBN NBN HDAC2 HDAC2 TP53INP1 TP53INP1 TAF1 TAF1 ENSCJAP00000074162 ENSCJAP00000074162 ENSCJAP00000073788 ENSCJAP00000073788 ENSCJAP00000073702 ENSCJAP00000073702 ENSCJAP00000073650 ENSCJAP00000073650 ENSCJAP00000073389 ENSCJAP00000073389 ENSCJAP00000073047 ENSCJAP00000073047 PRKAG3 PRKAG3 SMYD2 SMYD2 ENSCJAP00000072519 ENSCJAP00000072519 ENSCJAP00000071975 ENSCJAP00000071975 ENSCJAP00000071842 ENSCJAP00000071842 ENSCJAP00000071689 ENSCJAP00000071689 NUAK2 NUAK2 USP7 USP7 MBD3 MBD3 PPP1R13L PPP1R13L AKT1 AKT1 ENSCJAP00000070871 ENSCJAP00000070871 ENSCJAP00000070800 ENSCJAP00000070800 GATAD2B GATAD2B ENSCJAP00000070008 ENSCJAP00000070008 ENSCJAP00000069313 ENSCJAP00000069313 TP53INP2 TP53INP2 ENSCJAP00000068152 ENSCJAP00000068152 ENSCJAP00000067889 ENSCJAP00000067889 LOC100385218 LOC100385218 RFC4 RFC4 ENSCJAP00000067540 ENSCJAP00000067540 MAPK14 MAPK14 ENSCJAP00000067340 ENSCJAP00000067340 TP53 TP53 RPS27A-2 RPS27A-2 ENSCJAP00000065499 ENSCJAP00000065499 RBBP4 RBBP4 ENSCJAP00000064728 ENSCJAP00000064728 PIP4K2B PIP4K2B ENSCJAP00000064266 ENSCJAP00000064266 ENSCJAP00000064102 ENSCJAP00000064102 CDK2 CDK2 TP53RK TP53RK RBBP8 RBBP8 MAPKAPK5 MAPKAPK5 RFFL RFFL PRDM1 PRDM1 ENSCJAP00000062353 ENSCJAP00000062353 ZNF385C ZNF385C RAD1 RAD1 ENSCJAP00000060911 ENSCJAP00000060911 ENSCJAP00000060543 ENSCJAP00000060543 CDK1 CDK1 SSRP1 SSRP1 ENSCJAP00000059313 ENSCJAP00000059313 TP73 TP73 LOC100411827 LOC100411827 CDK5R1 CDK5R1 ENSCJAP00000057911 ENSCJAP00000057911 UBC UBC TAF7 TAF7 BANP BANP LOC100385843 LOC100385843 TAF12 TAF12 ENSCJAP00000055417 ENSCJAP00000055417 POU4F1 POU4F1 RFC5 RFC5 STK11 STK11 PPP2R1B PPP2R1B GATAD2A GATAD2A ENSCJAP00000053805 ENSCJAP00000053805 PIN1 PIN1 TP63 TP63 ENSCJAP00000052511 ENSCJAP00000052511 FOXP4 FOXP4 PPP2CA PPP2CA AURKB AURKB HIPK4 HIPK4 TOP3A TOP3A UBA52 UBA52 LOC100398346 LOC100398346 PPP2R5C PPP2R5C PRKAB1 PRKAB1 RBBP7 RBBP7 DYRK2 DYRK2 TAF11 TAF11 BRD9 BRD9 RPS27A RPS27A CHEK2 CHEK2 BLM BLM TAF6 TAF6 F6Q3J9_CALJA F6Q3J9_CALJA F7FKC4_CALJA F7FKC4_CALJA ZNF385B ZNF385B HIPK3 HIPK3 RMI1 RMI1 MBD3L1 MBD3L1 F7IQS9_CALJA F7IQS9_CALJA DAXX DAXX RECQL4 RECQL4 POU4F3 POU4F3 CSNK2A1 CSNK2A1 PRKAG1 PRKAG1 TPX2 TPX2 TAF4B TAF4B TAF3 TAF3 TBP TBP PRKAG2 PRKAG2 CDK5 CDK5 JMY JMY TAF9B TAF9B DNA2 DNA2 MTA2 MTA2 ZNF385A ZNF385A RHNO1 RHNO1 DYRK3 DYRK3 RFC3 RFC3 TAF5 TAF5 CCNA1 CCNA1 PML PML PHF20 PHF20 EXO1 EXO1 PPP1R13B PPP1R13B AKT3 AKT3 MDM4 MDM4 KMT5A KMT5A BRD1 BRD1 RAD17 RAD17 BRPF1 BRPF1 RMI2 RMI2 BRPF3 BRPF3 PRKAA2 PRKAA2 L3MBTL4 L3MBTL4 CCNG1 CCNG1 MLST8 MLST8 TAF15 TAF15 EXD2 EXD2 C17orf113 C17orf113 PDPK1 PDPK1 CHD3 CHD3 MEIOB MEIOB HUS1 HUS1 TXNDC11 TXNDC11 AKT2 AKT2 ING1 ING1 TAF10 TAF10 CDK3 CDK3 AIRE AIRE HIPK2 HIPK2 HIPK1 HIPK1 BRCA1 BRCA1 WRN WRN PPP2CB PPP2CB CSNK2A2 CSNK2A2 BARD1 BARD1 NOC2L NOC2L AURKA AURKA PPP2R1A PPP2R1A SLF1 SLF1 ATM ATM TTC5 TTC5 PIP4P1 PIP4P1 RAD9B RAD9B SUPT16H SUPT16H PRMT5 PRMT5 CHD4 CHD4 PIP4K2A PIP4K2A RICTOR RICTOR KXD1 KXD1 PRKAA1 PRKAA1 PIP4K2C PIP4K2C MAPKAP1 MAPKAP1 TAF2 TAF2 ING2 ING2 EP300 EP300 TAF7L TAF7L KAT6A KAT6A PLK3 PLK3 MRE11 MRE11 RFC2 RFC2 L3MBTL1 L3MBTL1 TDRD3 TDRD3 L3MBTL3 L3MBTL3 CCNA2 CCNA2 LY6G5B LY6G5B CSNK2B CSNK2B ATRIP ATRIP TBPL1 TBPL1 SGK1 SGK1 TAF13 TAF13 EHMT2 EHMT2 POU4F2 POU4F2 MTOR MTOR SETD9 SETD9 MEAF6 MEAF6 BRD7 BRD7 ATR ATR RPA1 RPA1 RNF34 RNF34 RAD9A RAD9A RPA3 RPA3 F6SBU8_CALJA F6SBU8_CALJA MAP2K6 MAP2K6 CHD5 CHD5 AURKC AURKC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCJAP00000071263Helicase ATP-binding domain-containing protein. (88 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa)
PIP4P2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
ENSCJAP00000078920Uncharacterized protein. (247 aa)
TAF4TATA-box binding protein associated factor 4. (1085 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (556 aa)
BRIP1Uncharacterized protein. (213 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1563 aa)
ENSCJAP00000077446Uncharacterized protein. (317 aa)
ENSCJAP00000077268Uncharacterized protein. (146 aa)
EHMT1Euchromatic histone lysine methyltransferase 1. (1510 aa)
NUAK1NUAK family SNF1-like kinase 1. (667 aa)
ENSCJAP00000076896Uncharacterized protein. (567 aa)
ENSCJAP00000075918Protein kinase domain-containing protein. (253 aa)
ENSCJAP00000075765Uncharacterized protein. (260 aa)
ENSCJAP00000075742Ubiquitin-like domain-containing protein. (156 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (748 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
TAF1Transcription initiation factor TFIID subunit. (1927 aa)
ENSCJAP00000074162CtIP_N domain-containing protein. (468 aa)
ENSCJAP00000073788RRM domain-containing protein. (610 aa)
ENSCJAP00000073702Uncharacterized protein. (153 aa)
ENSCJAP00000073650Ubiquitin-like domain-containing protein. (156 aa)
ENSCJAP00000073389Uncharacterized protein. (194 aa)
ENSCJAP00000073047Uncharacterized protein. (179 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (571 aa)
SMYD2N-lysine methyltransferase SMYD2. (433 aa)
ENSCJAP00000072519Peptidyl-prolyl cis-trans isomerase. (152 aa)
ENSCJAP00000071975Uncharacterized protein. (341 aa)
ENSCJAP00000071842TAFII28 domain-containing protein. (203 aa)
ENSCJAP00000071689Uncharacterized protein. (111 aa)
NUAK2NUAK family kinase 2. (650 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1136 aa)
MBD3Methyl-CpG binding domain protein 3. (380 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (837 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
ENSCJAP00000070871Ubiquitin-like domain-containing protein. (181 aa)
ENSCJAP00000070800TAFII28 domain-containing protein. (203 aa)
GATAD2BGATA zinc finger domain containing 2B. (617 aa)
ENSCJAP00000070008Uncharacterized protein. (89 aa)
ENSCJAP00000069313Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
ENSCJAP00000068152Uncharacterized protein. (132 aa)
ENSCJAP00000067889Hist_deacetyl domain-containing protein. (209 aa)
LOC100385218Ubiquitin-like domain-containing protein. (144 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSCJAP00000067540TAFII28 domain-containing protein. (203 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSCJAP00000067340Ubiquitin-like domain-containing protein. (143 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
RPS27A-2ubiquitin-40S ribosomal protein S27a. (156 aa)
ENSCJAP00000065499Uncharacterized protein. (77 aa)
RBBP4RB binding protein 4, chromatin remodeling factor. (425 aa)
ENSCJAP00000064728Uncharacterized protein. (276 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
ENSCJAP00000064266Ubiquitin-like domain-containing protein. (155 aa)
ENSCJAP00000064102Ubiquitin-like domain-containing protein. (147 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (345 aa)
TP53RKTP53-regulating kinase. (253 aa)
RBBP8RB binding protein 8, endonuclease. (872 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform 2. (473 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (364 aa)
PRDM1PR/SET domain 1. (838 aa)
ENSCJAP00000062353Protein kinase domain-containing protein. (229 aa)
ZNF385CZinc finger protein 385C. (496 aa)
RAD1RAD1 checkpoint DNA exonuclease. (283 aa)
ENSCJAP00000060911Ubiquitin-like domain-containing protein. (144 aa)
ENSCJAP00000060543Uncharacterized protein. (520 aa)
CDK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (297 aa)
SSRP1HMG box domain-containing protein. (828 aa)
ENSCJAP00000059313Uncharacterized protein. (153 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (635 aa)
LOC100411827Ubiquitin-like domain-containing protein. (127 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ENSCJAP00000057911Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (81 aa)
UBCUncharacterized protein. (305 aa)
TAF7Transcription initiation factor TFIID subunit 7. (349 aa)
BANPUncharacterized protein. (121 aa)
LOC100385843Uncharacterized protein. (147 aa)
TAF12Transcription initiation factor TFIID subunit 12. (161 aa)
ENSCJAP00000055417Ubiquitin-like domain-containing protein. (156 aa)
POU4F1POU domain protein. (421 aa)
RFC5Replication factor C subunit 5 isoform 1. (340 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (765 aa)
GATAD2AGATA zinc finger domain containing 2A. (748 aa)
ENSCJAP00000053805Uncharacterized protein. (124 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ENSCJAP00000052511Ubiquitin-like domain-containing protein. (77 aa)
FOXP4Forkhead box protein P4 isoform 1. (679 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (345 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
UBA52Ubiquitin-like domain-containing protein. (137 aa)
LOC100398346RAD50 homolog isoform 1 (Predicted). (1312 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (555 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (464 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa)
TAF11Transcription initiation factor TFIID subunit 11 isoform 1. (211 aa)
BRD9Bromodomain containing 9. (599 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CHEK2Uncharacterized protein. (543 aa)
BLMBLM RecQ like helicase. (1415 aa)
TAF6TATA-box binding protein associated factor 6. (713 aa)
F6Q3J9_CALJAUbiquitin-like domain-containing protein. (155 aa)
F7FKC4_CALJAFHA domain-containing protein. (300 aa)
ZNF385BZinc finger protein 385B. (499 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform 1. (1216 aa)
RMI1RecQ-mediated genome instability protein 1. (625 aa)
MBD3L1Methyl-CpG binding domain protein 3 like 1. (222 aa)
F7IQS9_CALJAUbiquitin-like domain-containing protein. (155 aa)
DAXXDeath domain-associated protein 6 isoform a. (742 aa)
RECQL4RecQ like helicase 4. (1204 aa)
POU4F3POU domain protein. (338 aa)
CSNK2A1Casein kinase II subunit alpha isoform a; Belongs to the protein kinase superfamily. (391 aa)
PRKAG1Uncharacterized protein. (340 aa)
TPX2TPX2 microtubule nucleation factor. (741 aa)
TAF4BTATA-box binding protein associated factor 4b. (868 aa)
TAF3TATA-box binding protein associated factor 3. (931 aa)
TBPTATA-box binding protein. (332 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (569 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (306 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (988 aa)
TAF9BTATA-box binding protein associated factor 9b. (312 aa)
DNA2DNA replication helicase/nuclease 2. (987 aa)
MTA2Metastasis associated 1 family member 2. (668 aa)
ZNF385AZinc finger protein 385A. (389 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1. (240 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (580 aa)
RFC3Replication factor C subunit 3 isoform 1. (356 aa)
TAF5Transcription initiation factor TFIID subunit 5. (800 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
PMLPromyelocytic leukemia. (881 aa)
PHF20PHD finger protein 20. (1012 aa)
EXO1Exonuclease 1. (852 aa)
PPP1R13BProtein phosphatase 1 regulatory subunit 13B. (1090 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
KMT5ALysine methyltransferase 5A. (352 aa)
BRD1Bromodomain containing 1. (1189 aa)
RAD17Cell cycle checkpoint protein RAD17 isoform 2. (681 aa)
BRPF1Uncharacterized protein. (1220 aa)
RMI2Uncharacterized protein. (84 aa)
BRPF3Bromodomain and PHD finger-containing protein 3. (1205 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
L3MBTL4L3MBTL histone methyl-lysine binding protein 4. (630 aa)
CCNG1Cyclin-G1; Belongs to the cyclin family. (295 aa)
MLST8Target of rapamycin complex subunit LST8 isoform a. (326 aa)
TAF15TATA-box binding protein associated factor 15. (592 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2 isoform 1. (621 aa)
C17orf113Chromosome 17 open reading frame 113. (675 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform 1. (556 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2056 aa)
MEIOBMeiosis specific with OB-fold. (470 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
TXNDC11Thioredoxin domain-containing protein 11. (954 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ING1Inhibitor of growth protein. (285 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (217 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
AIREAutoimmune regulator. (392 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform 1. (1196 aa)
HIPK1Uncharacterized protein. (1416 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
WRNWRN RecQ like helicase. (1433 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
CSNK2A2Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
BARD1BRCA1 associated RING domain 1. (853 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (921 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (401 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
SLF1Ankyrin repeat domain-containing protein 32. (1059 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
TTC5Tetratricopeptide repeat domain 5. (440 aa)
PIP4P1Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
CHD4Chromodomain-helicase-DNA-binding protein 4. (1912 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (406 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
KXD1KxDL motif containing 1. (175 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a. (421 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1 isoform 1. (522 aa)
TAF2TATA-box binding protein associated factor 2. (1323 aa)
ING2Inhibitor of growth protein. (279 aa)
EP300E1A binding protein p300. (2426 aa)
TAF7LTATA-box binding protein associated factor 7 like. (496 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2005 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (709 aa)
RFC2Replication factor C subunit 2. (352 aa)
L3MBTL1Uncharacterized protein. (853 aa)
TDRD3Tudor domain containing 3. (744 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (796 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (432 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (200 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (234 aa)
ATRIPATR-interacting protein isoform 1. (790 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
SGK1Non-specific serine/threonine protein kinase. (725 aa)
TAF13Transcription initiation factor TFIID subunit 13. (124 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1268 aa)
POU4F2POU domain protein. (408 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SETD9SET domain-containing protein 9 isoform 1. (299 aa)
MEAF6Chromatin modification-related protein MEAF6 isoform 1. (201 aa)
BRD7Bromodomain containing 7. (652 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (628 aa)
RNF34E3 ubiquitin-protein ligase RNF34 isoform 2. (372 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
F6SBU8_CALJAUncharacterized protein. (386 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CHD5Chromodomain helicase DNA binding protein 5. (2007 aa)
AURKCAurora kinase C isoform 1; Belongs to the protein kinase superfamily. (309 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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