STRINGSTRING
BTC BTC ENSCJAP00000078416 ENSCJAP00000078416 PPP4R1 PPP4R1 FLT3LG FLT3LG PIK3CD PIK3CD KLB KLB LCK LCK ERBB2 ERBB2 FGF6 FGF6 PPP2R5E PPP2R5E FNDC3B FNDC3B FAM102B FAM102B PPP2R5B PPP2R5B GAB1 GAB1 HGF HGF STRN STRN EGF EGF PPP2R5D PPP2R5D FYN FYN PDGFA PDGFA MET MET STRN3 STRN3 PIP4K2C PIP4K2C FGFR4 FGFR4 PIP5K1A PIP5K1A NRG1 NRG1 PIP4K2A PIP4K2A CD86 CD86 IL1RL1 IL1RL1 FNDC3A FNDC3A FGF3 FGF3 MYD88 MYD88 PPP2R1A PPP2R1A TRAF6 TRAF6 FGF20 FGF20 ERBB3 ERBB3 NRG4 NRG4 PPP2CB PPP2CB PTPN11 PTPN11 FGF22 FGF22 PIK3CA PIK3CA IRAK4 IRAK4 AREG AREG PIK3R2 PIK3R2 IL1RAP IL1RAP FGF4 FGF4 IRAK1 IRAK1 NARS2 NARS2 PPP2R5A PPP2R5A PIK3R1 PIK3R1 SPEM2 SPEM2 SPEM1 SPEM1 WDR64 WDR64 FGF8 FGF8 CD80 CD80 CD276 CD276 FGF19 FGF19 INS INS KL KL PDGFRA PDGFRA TGFA TGFA FLT3 FLT3 ESR1 ESR1 ESR2 ESR2 KITLG KITLG PIP5KL1 PIP5KL1 FAM102A FAM102A FNBP4 FNBP4 FGF17 FGF17 PIK3R3 PIK3R3 VAV1 VAV1 FGF1 FGF1 MAPK1 MAPK1 NRG2 NRG2 FRS2 FRS2 EPGN EPGN PPP2R5C PPP2R5C TRAT1 TRAT1 FGF5 FGF5 PPP2CA PPP2CA PIK3CB PIK3CB FGF10 FGF10 INSR INSR RHOG RHOG IRS2 IRS2 PPP2R1B PPP2R1B KIT KIT HBEGF HBEGF ENSCJAP00000056577 ENSCJAP00000056577 F7GTV7_CALJA F7GTV7_CALJA PIK3AP1 PIK3AP1 MAPK3 MAPK3 FGF16 FGF16 FGFR3 FGFR3 NRG3 NRG3 IL33 IL33 IER3 IER3 PPP4R4 PPP4R4 PDGFB PDGFB EREG EREG PIP4K2B PIP4K2B PIP5K1B PIP5K1B FGFR2 FGFR2 RELCH RELCH EPGN-2 EPGN-2 GRB2 GRB2 CD28 CD28 ICOS ICOS ERBB4 ERBB4 FGF23 FGF23 CD19 CD19 AKT1 AKT1 IRS1 IRS1 PIP5K1C PIP5K1C PDGFRB PDGFRB ENSCJAP00000072746 ENSCJAP00000072746 FGFR1 FGFR1 CALCB CALCB SRC SRC FGF18 FGF18 EGFR EGFR FGF9 FGF9 FGF7 FGF7 BANK1 BANK1 STRN4 STRN4 FGF2 FGF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BTCProbetacellulin. (178 aa)
ENSCJAP00000078416Uncharacterized protein. (918 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (984 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (224 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KLBKlotho beta. (1045 aa)
LCKTyrosine-protein kinase. (539 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1204 aa)
FAM102BFamily with sequence similarity 102 member B. (360 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (646 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (813 aa)
STRNStriatin. (780 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (600 aa)
FYNTyrosine-protein kinase. (537 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (443 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1353 aa)
STRN3Striatin-3 isoform 1. (797 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform a. (421 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2. (550 aa)
NRG1Neuregulin 1. (713 aa)
PIP4K2APhosphatidylinositol 5-phosphate 4-kinase type-2 alpha. (406 aa)
CD86Ig-like domain-containing protein. (361 aa)
IL1RL1Interleukin 1 receptor like 1. (557 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform 1. (1198 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (537 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3 isoform 1. (1341 aa)
NRG4Neuregulin 4. (115 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (600 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform a. (460 aa)
AREGAmphiregulin. (275 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform 3. (687 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
IRAK1Interleukin-1 receptor-associated kinase 1 isoform 1 (Predicted). (712 aa)
NARS2GRB2-associated-binding protein 2 isoform a. (676 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1. (724 aa)
SPEM2SPEM family member 2. (496 aa)
SPEM1Spermatid maturation 1. (308 aa)
WDR64WD repeat domain 64. (1121 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CD80Uncharacterized protein. (348 aa)
CD276CD276 molecule. (534 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
KLKlotho. (1012 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
TGFATransforming growth factor alpha. (165 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (993 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ESR2Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (530 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PIP5KL1Phosphatidylinositol-4-phosphate 5-kinase like 1. (454 aa)
FAM102AFamily with sequence similarity 102 member A. (384 aa)
FNBP4Formin-binding protein 4. (1019 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
NRG2Neuregulin 2. (847 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
EPGNEGF-like domain-containing protein. (187 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (555 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (186 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1; Belongs to the PI3/PI4-kinase family. (1070 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
RHOGRho-related GTP-binding protein RhoG. (191 aa)
IRS2Insulin receptor substrate 2. (1327 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (765 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (976 aa)
HBEGFHeparin binding EGF like growth factor. (218 aa)
ENSCJAP00000056577Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (277 aa)
F7GTV7_CALJAUncharacterized protein. (151 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (805 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFR3Fibroblast growth factor receptor. (810 aa)
NRG3Neuregulin 3. (720 aa)
IL33Interleukin 33. (270 aa)
IER3Radiation-inducible immediate-early gene IEX-1. (156 aa)
PPP4R4Serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform 1. (873 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
EREGEpiregulin. (169 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (555 aa)
FGFR2Fibroblast growth factor receptor. (822 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1253 aa)
EPGN-2Epithelial mitogen. (187 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
CD28IGv domain-containing protein. (234 aa)
ICOSInducible T cell costimulator. (211 aa)
ERBB4Receptor protein-tyrosine kinase. (1331 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (300 aa)
CD19B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in [...] (623 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
IRS1Insulin receptor substrate 1. (1254 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1108 aa)
ENSCJAP00000072746Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (454 aa)
FGFR1Fibroblast growth factor receptor. (885 aa)
CALCBINSC_LBD domain-containing protein. (593 aa)
SRCTyrosine-protein kinase. (553 aa)
FGF18Uncharacterized protein; Belongs to the heparin-binding growth factors family. (378 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (332 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (796 aa)
STRN4Striatin 4. (743 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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