(152 nodes) KEAP1-NFE2L2 pathway network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCJAP00000067340	Ubiquitin-like domain-containing protein. (143 aa)
	MTFP1	Mitochondrial fission process protein 1 isoform a. (166 aa)
	PSMD3	26S proteasome non-ATPase regulatory subunit 3. (534 aa)
	HMOX1	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
	BACH2	BTB domain and CNC homolog 2. (844 aa)
	DPP3	Dipeptidyl peptidase 3; Belongs to the peptidase M49 family. (757 aa)
	NPLOC4	Nuclear protein localization protein 4 homolog. (608 aa)
	SPATA5L1	Spermatogenesis-associated protein 5-like protein 1. (753 aa)
	KLHL18	Kelch like family member 18. (654 aa)
	ATF4	Activating transcription factor 4. (351 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (234 aa)
	LY6G5B	Lymphocyte antigen 6 family member G5B. (200 aa)
	SLC7A11	Cystine/glutamate transporter. (501 aa)
	GSR	Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. (522 aa)
	SPATA5	Spermatogenesis associated 5. (811 aa)
	RBX1	E3 ubiquitin-protein ligase RBX1. (108 aa)
	EP300	E1A binding protein p300. (2426 aa)
	PRDX1	Peroxiredoxin-1. (199 aa)
	KIAA2012	KIAA2012. (1181 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (378 aa)
	SESN1	Sestrin-1 isoform 1. (551 aa)
	PSMB7	Proteasome subunit beta. (277 aa)
	KEAP1	Kelch-like ECH-associated protein 1. (624 aa)
	PSMC6	26S protease regulatory subunit 10B; Belongs to the AAA ATPase family. (403 aa)
	F6ZZS4_CALJA	Uncharacterized protein. (254 aa)
	TKT	Transketolase isoform 1. (623 aa)
	KXD1	KxDL motif containing 1. (175 aa)
	NFE2L1	Nuclear factor erythroid 2-related factor 1. (772 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	NFE2L3	Nuclear factor, erythroid 2 like 3. (684 aa)
	F7EMD2_CALJA	Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (247 aa)
	PSMD12	26S proteasome non-ATPase regulatory subunit 12 isoform 1. (456 aa)
	TRIM58	Tripartite motif containing 58. (490 aa)
	VCP	Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (806 aa)
	CUL1	Cullin-1; Belongs to the cullin family. (776 aa)
	SQSTM1	Sequestosome-1 isoform 1. (439 aa)
	NOTCH1	Notch receptor 1. (2551 aa)
	TXNRD3	Thioredoxin reductase 3; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (707 aa)
	CSNK2A2	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (350 aa)
	TALDO1	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
	MAFK	MAF bZIP transcription factor K. (149 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	CUL3	Cullin-3 isoform 1; Belongs to the cullin family. (768 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
	PSME3	Proteasome activator subunit 3. (267 aa)
	PSMD1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (959 aa)
	PSMD8	26S proteasome non-ATPase regulatory subunit 8. (350 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	PSMC4	26S protease regulatory subunit 6B isoform 1; Belongs to the AAA ATPase family. (418 aa)
	PSMD11	26S proteasome non-ATPase regulatory subunit 11. (422 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	TXNRD1	Thioredoxin reductase 1. (650 aa)
	PSMD7	26S proteasome non-ATPase regulatory subunit 7. (324 aa)
	TRIM21	E3 ubiquitin-protein ligase TRIM21. (475 aa)
	PSMB10	Proteasome subunit beta. (274 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (704 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (563 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	PSMC1	26S protease regulatory subunit 4; Belongs to the AAA ATPase family. (440 aa)
	AMER1	APC membrane recruitment protein 1. (1134 aa)
	GCLM	Gamma-glutamylcysteine synthetase regulatory subunit. (274 aa)
	UBXN7	UBX domain-containing protein 7. (489 aa)
	MAFG	MAF bZIP transcription factor G. (162 aa)
	SKP2	S-phase kinase associated protein 2. (422 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMC5	26S protease regulatory subunit 8 isoform 1; Belongs to the AAA ATPase family. (406 aa)
	CREBBP	CREB-binding protein isoform a. (2449 aa)
	PSMC3	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (439 aa)
	PSMD5	26S proteasome non-ATPase regulatory subunit 5 isoform 1. (504 aa)
	PSMB1	Proteasome subunit beta. (241 aa)
	PSMA8	Proteasome subunit alpha type. (256 aa)
	CSNK2A1	Casein kinase II subunit alpha isoform a; Belongs to the protein kinase superfamily. (391 aa)
	SRXN1	Sulfiredoxin. (137 aa)
	PSMC2	26S protease regulatory subunit 7 isoform 1; Belongs to the AAA ATPase family. (433 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	PSMB9	Proteasome subunit beta. (219 aa)
	F7IQS9_CALJA	Ubiquitin-like domain-containing protein. (155 aa)
	F7HPY0_CALJA	Uncharacterized protein. (238 aa)
	F7EAY8_CALJA	Uncharacterized protein. (239 aa)
	F6WC44_CALJA	Uncharacterized protein; Belongs to the SKP1 family. (160 aa)
	PSME2	Uncharacterized protein. (239 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (643 aa)
	ME1	Malic enzyme. (572 aa)
	F6Q3J9_CALJA	Ubiquitin-like domain-containing protein. (155 aa)
	PGD	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	PSMA2	Proteasome endopeptidase complex. (245 aa)
	UBA52	Ubiquitin-like domain-containing protein. (137 aa)
	PSMA5	Proteasome subunit alpha type. (241 aa)
	GSK3B	Glycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily. (433 aa)
	BACH1	BTB domain and CNC homolog 1. (736 aa)
	PSME4	Proteasome activator complex subunit 4. (1843 aa)
	ENSCJAP00000052511	Ubiquitin-like domain-containing protein. (77 aa)
	SESN2	Sestrin-2. (480 aa)
	PSMA6	Proteasome subunit alpha type. (246 aa)
	PSMD6	Proteasome 26S subunit, non-ATPase 6. (489 aa)
	ENSCJAP00000054053	AAA domain-containing protein; Belongs to the AAA ATPase family. (455 aa)
	PSME1	Proteasome activator complex subunit 1 isoform 2. (250 aa)
	ENSCJAP00000055417	Ubiquitin-like domain-containing protein. (156 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (527 aa)
	UBC	Uncharacterized protein. (305 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (468 aa)
	LOC100411827	Ubiquitin-like domain-containing protein. (127 aa)
	ENSCJAP00000059313	Uncharacterized protein. (153 aa)
	PSMB5	Proteasome subunit beta. (263 aa)
	MAP1LC3B	Microtubule-associated proteins 1A/1B light chain 3B. (125 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	UFD1	Uncharacterized protein. (424 aa)
	ENSCJAP00000060911	Ubiquitin-like domain-containing protein. (144 aa)
	PSMB3	Proteasome subunit beta. (206 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (158 aa)
	PSMF1	Proteasome inhibitor PI31 subunit. (271 aa)
	PSMD4	26S proteasome non-ATPase regulatory subunit 4. (380 aa)
	ENSCJAP00000063116	Rpn3_C domain-containing protein. (105 aa)
	ENSCJAP00000064102	Ubiquitin-like domain-containing protein. (147 aa)
	ENSCJAP00000064266	Ubiquitin-like domain-containing protein. (155 aa)
	ENSCJAP00000065377	PCI domain-containing protein. (454 aa)
	RPS27A-2	ubiquitin-40S ribosomal protein S27a. (156 aa)
	PSMD2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (622 aa)
	PSMA1	Proteasome subunit alpha type. (283 aa)
	ENSCJAP00000078155	MPN domain-containing protein. (309 aa)
	ENSCJAP00000077717	Uncharacterized protein. (173 aa)
	ENSCJAP00000075742	Ubiquitin-like domain-containing protein. (156 aa)
	ENSCJAP00000075036	AAA domain-containing protein. (245 aa)
	PSMD9	26S proteasome non-ATPase regulatory subunit 9 isoform 1. (223 aa)
	PSMB11	Proteasome subunit beta. (231 aa)
	PSMA4	Proteasome subunit alpha type. (284 aa)
	ENSCJAP00000074381	Malic domain-containing protein. (300 aa)
	ENSCJAP00000074230	Uncharacterized protein; Belongs to the SKP1 family. (115 aa)
	SKP1	S-phase kinase-associated protein 1 isoform b; Belongs to the SKP1 family. (163 aa)
	ENSCJAP00000073823	Zf-rbx1 domain-containing protein. (82 aa)
	NQO1	Flavodoxin_2 domain-containing protein. (280 aa)
	KLHL17	BTB domain-containing protein. (663 aa)
	ENSCJAP00000073650	Ubiquitin-like domain-containing protein. (156 aa)
	PSMD10	26S proteasome non-ATPase regulatory subunit 10 isoform 1. (226 aa)
	PALB2	Partner and localizer of BRCA2. (1182 aa)
	ENSCJAP00000072716	ANK_REP_REGION domain-containing protein. (154 aa)
	ENSCJAP00000072387	Uncharacterized protein. (161 aa)
	ENSCJAP00000071975	Uncharacterized protein. (341 aa)
	ENSCJAP00000071199	Thioredoxin domain-containing protein. (133 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (459 aa)
	ENSCJAP00000070951	AAA domain-containing protein. (421 aa)
	ENSCJAP00000070871	Ubiquitin-like domain-containing protein. (181 aa)
	ENSCJAP00000070591	PCI domain-containing protein. (238 aa)
	PRKCD	Protein kinase C delta. (775 aa)
	ENSCJAP00000068855	Uncharacterized protein. (222 aa)
	LOC100385218	Ubiquitin-like domain-containing protein. (144 aa)
	ENSCJAP00000067376	AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSCJAP00000070985	ENSCJAP00000026859	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.964
AKT1	AKT3	ENSCJAP00000070985	ENSCJAP00000031436	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.940
AKT1	ATF4	ENSCJAP00000070985	ENSCJAP00000004703	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Activating transcription factor 4.	0.742
AKT1	BACH1	ENSCJAP00000070985	ENSCJAP00000051511	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BTB domain and CNC homolog 1.	0.419
AKT1	BACH2	ENSCJAP00000070985	ENSCJAP00000001733	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	BTB domain and CNC homolog 2.	0.419
AKT1	BRCA1	ENSCJAP00000070985	ENSCJAP00000023883	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.967
AKT1	CDKN1A	ENSCJAP00000070985	ENSCJAP00000061908	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase inhibitor 1.	0.981
AKT1	CREBBP	ENSCJAP00000070985	ENSCJAP00000036680	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	CREB-binding protein isoform a.	0.488
AKT1	CUL1	ENSCJAP00000070985	ENSCJAP00000018517	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cullin-1; Belongs to the cullin family.	0.441
AKT1	ENSCJAP00000071975	ENSCJAP00000070985	ENSCJAP00000071975	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.660
AKT1	EP300	ENSCJAP00000070985	ENSCJAP00000008779	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	E1A binding protein p300.	0.750
AKT1	GSK3B	ENSCJAP00000070985	ENSCJAP00000051282	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Glycogen synthase kinase-3 beta isoform 1; Belongs to the protein kinase superfamily.	0.994
AKT1	HMOX1	ENSCJAP00000070985	ENSCJAP00000000882	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.	0.426
AKT1	KEAP1	ENSCJAP00000070985	ENSCJAP00000012371	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Kelch-like ECH-associated protein 1.	0.400
AKT1	MYC	ENSCJAP00000070985	ENSCJAP00000023101	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.634
AKT1	NFE2L1	ENSCJAP00000070985	ENSCJAP00000014044	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor erythroid 2-related factor 1.	0.501
AKT1	NFE2L2	ENSCJAP00000070985	ENSCJAP00000078532	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 2.	0.701
AKT1	NFE2L3	ENSCJAP00000070985	ENSCJAP00000014623	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Nuclear factor, erythroid 2 like 3.	0.501
AKT1	NOTCH1	ENSCJAP00000070985	ENSCJAP00000020179	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Notch receptor 1.	0.650
AKT1	SKP2	ENSCJAP00000070985	ENSCJAP00000033902	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	S-phase kinase associated protein 2.	0.694