STRINGSTRING
HDAC1 HDAC1 PAX5 PAX5 LOC100385831 LOC100385831 MYC MYC LOC100398205 LOC100398205 LOC100394455 LOC100394455 LOC100394573 LOC100394573 LOC100413207 LOC100413207 LOC100414113 LOC100414113 LOC100389168 LOC100389168 FOXA1 FOXA1 TLE1 TLE1 ENSCJAP00000063804 ENSCJAP00000063804 LOC100385283 LOC100385283 ENSCJAP00000065541 ENSCJAP00000065541 SIX2 SIX2 ENSCJAP00000074198 ENSCJAP00000074198 LOC100386265 LOC100386265
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa)
PAX5Paired box 5. (393 aa)
LOC100385831Histone H3; Belongs to the histone H3 family. (135 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
LOC100398205Histone H3; Belongs to the histone H3 family. (136 aa)
LOC100394455Histone H3; Belongs to the histone H3 family. (136 aa)
LOC100394573Histone H3; Belongs to the histone H3 family. (136 aa)
LOC100413207Histone H3; Belongs to the histone H3 family. (135 aa)
LOC100414113Histone H3; Belongs to the histone H3 family. (136 aa)
LOC100389168Histone H3; Belongs to the histone H3 family. (136 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (467 aa)
TLE1TLE family member 1, transcriptional corepressor. (804 aa)
ENSCJAP00000063804Histone H3; Belongs to the histone H3 family. (135 aa)
LOC100385283Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCJAP00000065541Histone H3; Belongs to the histone H3 family. (136 aa)
SIX2Homeobox protein SIX2. (291 aa)
ENSCJAP00000074198Histone H3; Belongs to the histone H3 family. (124 aa)
LOC100386265Histone domain-containing protein. (136 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.