STRINGSTRING
NANOG NANOG INS INS ACR ACR PTPRZ1 PTPRZ1 TEKT1 TEKT1 DAZL DAZL MYC MYC CTCF CTCF CXCR4 CXCR4 PIWIL1 PIWIL1 LIF LIF NANOS3 NANOS3 BOLL BOLL KLF4 KLF4 POU5F1 POU5F1 BMP7 BMP7 BMP4 BMP4 NANOS1 NANOS1 NANOS2 NANOS2 KIT KIT SOX2 SOX2 BMP8A BMP8A POU5F1-2 POU5F1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NANOGHomeobox domain-containing protein. (305 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
ACRAcrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. (402 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2279 aa)
TEKT1Tektin-1. (418 aa)
DAZLDeleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity). (316 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
CTCFTranscriptional repressor CTCF isoform 1. (727 aa)
CXCR4C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (352 aa)
PIWIL1Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (861 aa)
LIFLIF interleukin 6 family cytokine. (241 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (167 aa)
BOLLBoule homolog, RNA binding protein. (295 aa)
KLF4Kruppel like factor 4. (507 aa)
POU5F1POU-specific domain-containing protein. (484 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
BMP4Bone morphogenetic protein 4 preproprotein. (408 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (413 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (141 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (976 aa)
SOX2Transcription factor SOX-2. (319 aa)
BMP8ABone morphogenetic protein 8B preproprotein. (402 aa)
POU5F1-2Uncharacterized protein. (146 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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