(22 nodes) (2011) MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression. network (Callithrix jacchus)

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Your Input:
	LOC100385831	Histone H3; Belongs to the histone H3 family. (135 aa)
	VCL	Vinculin. (1128 aa)
	CDC25A	M-phase inducer phosphatase 1 isoform a. (524 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	ALB	Albumin. (608 aa)
	PXDNL	Peroxidasin like. (1457 aa)
	BRCA2	BRCA2 DNA repair associated. (3409 aa)
	DROSHA	Ribonuclease 3 isoform 1. (1374 aa)
	LOC100398205	Histone H3; Belongs to the histone H3 family. (136 aa)
	MDC1	Mediator of DNA damage checkpoint 1. (2172 aa)
	LOC100398346	RAD50 homolog isoform 1 (Predicted). (1312 aa)
	LOC100394455	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100394573	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100413207	Histone H3; Belongs to the histone H3 family. (135 aa)
	LOC100414113	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100389168	Histone H3; Belongs to the histone H3 family. (136 aa)
	ENSCJAP00000063804	Histone H3; Belongs to the histone H3 family. (135 aa)
	LOC100385283	Histone H3; Belongs to the histone H3 family. (136 aa)
	ENSCJAP00000065541	Histone H3; Belongs to the histone H3 family. (136 aa)
	PXDN	Uncharacterized protein. (691 aa)
	ENSCJAP00000074198	Histone H3; Belongs to the histone H3 family. (124 aa)
	LOC100386265	Histone domain-containing protein. (136 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	LOC100394455	ENSCJAP00000025792	ENSCJAP00000053025	Albumin.	Histone H3; Belongs to the histone H3 family.	0.545
ALB	PXDN	ENSCJAP00000025792	ENSCJAP00000071540	Albumin.	Uncharacterized protein.	0.945
ALB	PXDNL	ENSCJAP00000025792	ENSCJAP00000027032	Albumin.	Peroxidasin like.	0.944
ALB	VCL	ENSCJAP00000025792	ENSCJAP00000002382	Albumin.	Vinculin.	0.492
ATM	BRCA2	ENSCJAP00000018844	ENSCJAP00000034250	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.966
ATM	CDC25A	ENSCJAP00000018844	ENSCJAP00000004914	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	M-phase inducer phosphatase 1 isoform a.	0.617
ATM	DROSHA	ENSCJAP00000018844	ENSCJAP00000035201	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ribonuclease 3 isoform 1.	0.427
ATM	ENSCJAP00000063804	ENSCJAP00000018844	ENSCJAP00000063804	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	ENSCJAP00000065541	ENSCJAP00000018844	ENSCJAP00000065541	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	ENSCJAP00000074198	ENSCJAP00000018844	ENSCJAP00000074198	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	LOC100385283	ENSCJAP00000018844	ENSCJAP00000064017	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	LOC100385831	ENSCJAP00000018844	ENSCJAP00000020356	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	LOC100386265	ENSCJAP00000018844	ENSCJAP00000078339	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone domain-containing protein.	0.464
ATM	LOC100389168	ENSCJAP00000018844	ENSCJAP00000060322	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	LOC100394455	ENSCJAP00000018844	ENSCJAP00000053025	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.545
ATM	LOC100394573	ENSCJAP00000018844	ENSCJAP00000055016	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.461
ATM	LOC100398205	ENSCJAP00000018844	ENSCJAP00000042887	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	LOC100398346	ENSCJAP00000018844	ENSCJAP00000048534	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD50 homolog isoform 1 (Predicted).	0.997
ATM	LOC100413207	ENSCJAP00000018844	ENSCJAP00000057329	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464
ATM	LOC100414113	ENSCJAP00000018844	ENSCJAP00000058297	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.464