(16 nodes) (2012) A dominant negative ERbeta splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. network (Callithrix jacchus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	ST13	ST13 Hsp70 interacting protein. (369 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (294 aa)
	LOC100385831	Histone H3; Belongs to the histone H3 family. (135 aa)
	LOC100386265	Histone domain-containing protein. (136 aa)
	ENSCJAP00000074198	Histone H3; Belongs to the histone H3 family. (124 aa)
	ENSCJAP00000065541	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100385283	Histone H3; Belongs to the histone H3 family. (136 aa)
	ENSCJAP00000063804	Histone H3; Belongs to the histone H3 family. (135 aa)
	LOC100389168	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100414113	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100413207	Histone H3; Belongs to the histone H3 family. (135 aa)
	LOC100394573	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100394455	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC100398205	Histone H3; Belongs to the histone H3 family. (136 aa)
	ESR2	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. (530 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCJAP00000063804	ESR1	ENSCJAP00000063804	ENSCJAP00000036232	Histone H3; Belongs to the histone H3 family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.525
ENSCJAP00000063804	LOC100394455	ENSCJAP00000063804	ENSCJAP00000053025	Histone H3; Belongs to the histone H3 family.	Histone H3; Belongs to the histone H3 family.	0.674
ENSCJAP00000065541	ESR1	ENSCJAP00000065541	ENSCJAP00000036232	Histone H3; Belongs to the histone H3 family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.522
ENSCJAP00000065541	LOC100394455	ENSCJAP00000065541	ENSCJAP00000053025	Histone H3; Belongs to the histone H3 family.	Histone H3; Belongs to the histone H3 family.	0.584
ENSCJAP00000074198	ESR1	ENSCJAP00000074198	ENSCJAP00000036232	Histone H3; Belongs to the histone H3 family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.522
ENSCJAP00000074198	LOC100394455	ENSCJAP00000074198	ENSCJAP00000053025	Histone H3; Belongs to the histone H3 family.	Histone H3; Belongs to the histone H3 family.	0.585
ESR1	ENSCJAP00000063804	ENSCJAP00000036232	ENSCJAP00000063804	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.525
ESR1	ENSCJAP00000065541	ENSCJAP00000036232	ENSCJAP00000065541	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.522
ESR1	ENSCJAP00000074198	ENSCJAP00000036232	ENSCJAP00000074198	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.522
ESR1	ESR2	ENSCJAP00000036232	ENSCJAP00000036235	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation.	0.995
ESR1	LOC100385283	ENSCJAP00000036232	ENSCJAP00000064017	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.522
ESR1	LOC100385831	ENSCJAP00000036232	ENSCJAP00000020356	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.525
ESR1	LOC100386265	ENSCJAP00000036232	ENSCJAP00000078339	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone domain-containing protein.	0.522
ESR1	LOC100389168	ENSCJAP00000036232	ENSCJAP00000060322	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.522
ESR1	LOC100394455	ENSCJAP00000036232	ENSCJAP00000053025	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.599
ESR1	LOC100394573	ENSCJAP00000036232	ENSCJAP00000055016	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.523
ESR1	LOC100398205	ENSCJAP00000036232	ENSCJAP00000042887	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.525
ESR1	LOC100413207	ENSCJAP00000036232	ENSCJAP00000057329	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.525
ESR1	LOC100414113	ENSCJAP00000036232	ENSCJAP00000058297	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Histone H3; Belongs to the histone H3 family.	0.522
ESR1	NGF	ENSCJAP00000036232	ENSCJAP00000023356	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nerve growth factor; Belongs to the NGF-beta family.	0.433