(41 nodes) (2013) Generation of integration-free and region-specific neural progenitors from primate fibroblasts. network (Callithrix jacchus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	EMX1	Empty spiracles homeobox 1. (290 aa)
	IRX3	Iroquois homeobox 3. (501 aa)
	HES5	Hes family bHLH transcription factor 5. (162 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1717 aa)
	FOXG1	Forkhead box G1. (505 aa)
	HOXB6	Homeobox protein Hox-B6. (224 aa)
	HOXB4	Homeobox B4. (252 aa)
	HOXB2	Homeobox protein Hox-B2. (356 aa)
	PAX7	Paired box 7. (517 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	HOXA2	Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily. (375 aa)
	HOXA3	Homeobox A3 isoform a (Predicted). (443 aa)
	F7EMI9_CALJA	Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
	LIF	LIF interleukin 6 family cytokine. (241 aa)
	GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase. (408 aa)
	NOTCH1	Notch receptor 1. (2551 aa)
	SYN1	Synapsin I. (706 aa)
	NANOG	Homeobox domain-containing protein. (305 aa)
	POU5F1-2	Uncharacterized protein. (146 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	F7H580_CALJA	Glyceraldehyde-3-phosphate dehydrogenase. (319 aa)
	SOX2	Transcription factor SOX-2. (319 aa)
	PAX2	Paired box 2. (448 aa)
	FABP7	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (155 aa)
	ENSCJAP00000053284	Glyceraldehyde-3-phosphate dehydrogenase. (332 aa)
	EN1	Homeobox protein engrailed-like. (391 aa)
	OTX2	Uncharacterized protein. (35 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
	KLF4	Kruppel like factor 4. (507 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
	POU5F1	POU-specific domain-containing protein. (484 aa)
	CDH2	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] (984 aa)
	SYN3	Synapsin III isoform IIIa (Predicted). (580 aa)
	GBX2	Gastrulation brain homeobox 2. (348 aa)
	ENSCJAP00000066250	Glyceraldehyde-3-phosphate dehydrogenase. (357 aa)
	GFAP	Glial fibrillary acidic protein; Belongs to the intermediate filament family. (504 aa)
	ENSCJAP00000064616	Glyceraldehyde-3-phosphate dehydrogenase. (328 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (292 aa)
	HOXB8	Homeobox B8. (243 aa)
	OLIG2	Oligodendrocyte lineage transcription factor 2 (Predicted). (323 aa)
	PAX6	Paired box 6. (472 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	FGF2	ENSCJAP00000074271	ENSCJAP00000077619	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.780
BDNF	FOXG1	ENSCJAP00000074271	ENSCJAP00000011408	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Forkhead box G1.	0.507
BDNF	GAPDHS	ENSCJAP00000074271	ENSCJAP00000019030	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Glyceraldehyde-3-phosphate dehydrogenase.	0.450
BDNF	GDNF	ENSCJAP00000074271	ENSCJAP00000014402	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Glial cell derived neurotrophic factor.	0.955
BDNF	GFAP	ENSCJAP00000074271	ENSCJAP00000066163	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Glial fibrillary acidic protein; Belongs to the intermediate filament family.	0.757
BDNF	LIF	ENSCJAP00000074271	ENSCJAP00000018988	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	LIF interleukin 6 family cytokine.	0.495
BDNF	NES	ENSCJAP00000074271	ENSCJAP00000011219	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Nestin; Belongs to the intermediate filament family.	0.730
BDNF	NTF3	ENSCJAP00000074271	ENSCJAP00000062610	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.823
BDNF	OLIG2	ENSCJAP00000074271	ENSCJAP00000058533	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Oligodendrocyte lineage transcription factor 2 (Predicted).	0.553
BDNF	OTX2	ENSCJAP00000074271	ENSCJAP00000057088	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Uncharacterized protein.	0.648
BDNF	PAX6	ENSCJAP00000074271	ENSCJAP00000057969	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Paired box 6.	0.550
BDNF	POU5F1	ENSCJAP00000074271	ENSCJAP00000071643	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	POU-specific domain-containing protein.	0.410
BDNF	POU5F1-2	ENSCJAP00000074271	ENSCJAP00000036806	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Uncharacterized protein.	0.410
BDNF	SHH	ENSCJAP00000074271	ENSCJAP00000037954	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.775
BDNF	SOX2	ENSCJAP00000074271	ENSCJAP00000047836	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Transcription factor SOX-2.	0.458
BDNF	SYN1	ENSCJAP00000074271	ENSCJAP00000022965	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Synapsin I.	0.653
BDNF	SYN3	ENSCJAP00000074271	ENSCJAP00000048037	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Synapsin III isoform IIIa (Predicted).	0.556
CDH2	FGF2	ENSCJAP00000070836	ENSCJAP00000077619	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.405
CDH2	NANOG	ENSCJAP00000070836	ENSCJAP00000035305	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...]	Homeobox domain-containing protein.	0.453
CDH2	NES	ENSCJAP00000070836	ENSCJAP00000011219	Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...]	Nestin; Belongs to the intermediate filament family.	0.473