(53 nodes) (2014) Growth and folding of the mammalian cerebral cortex: from molecules to malformations. network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IGF1R	Tyrosine-protein kinase receptor. (1366 aa)
	DCX	Doublecortin. (366 aa)
	LMO4	Uncharacterized protein. (218 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (332 aa)
	FGF18	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (378 aa)
	FGFR1	Fibroblast growth factor receptor. (885 aa)
	NDE1	NudE neurodevelopment protein 1. (488 aa)
	IGF2	Insulin like growth factor 2. (348 aa)
	CEP120	Centrosomal protein of 120 kDa isoform 1. (986 aa)
	SUN2	Sad1 and UNC84 domain containing 2. (860 aa)
	TRNP1	TMF1 regulated nuclear protein 1. (227 aa)
	FGFR2	Fibroblast growth factor receptor. (822 aa)
	HOOK3	Protein Hook homolog 3. (720 aa)
	EFNA5	Ephrin-A5; Belongs to the ephrin family. (228 aa)
	CDC42	Cell division control protein 42 homolog isoform 1. (191 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	CALML3	Calmodulin-like protein 3; Belongs to the calmodulin family. (149 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	FGFR3	Fibroblast growth factor receptor. (810 aa)
	CALML5	Calmodulin-like protein 5. (146 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (891 aa)
	PAX6	Paired box 6. (472 aa)
	EMX1	Empty spiracles homeobox 1. (290 aa)
	EPHA7	Ephrin type-A receptor 7. (998 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	RHOG	Rho-related GTP-binding protein RhoG. (191 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (531 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	GPSM2	G-protein-signaling modulator 2. (685 aa)
	TCOF1	Treacle ribosome biogenesis factor 1. (1456 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	FLNA	Filamin A. (2649 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	ZNF335	Zinc finger protein 335. (1345 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	FOXP2	Forkhead box P2. (738 aa)
	DOCK7	Dedicator of cytokinesis protein 7 isoform 1; Belongs to the DOCK family. (2140 aa)
	STAU1	Uncharacterized protein. (588 aa)
	NUMB	NUMB endocytic adaptor protein. (651 aa)
	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta. (727 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	CALML6	Calmodulin like 6. (180 aa)
	FANCA	FA complementation group A. (1394 aa)
	WDR62	WD repeat-containing protein 62 isoform 1. (1525 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (400 aa)
	STAU2	Double-stranded RNA-binding protein Staufen homolog 2 isoform a. (570 aa)
	MCPH1	Microcephalin isoform 1. (840 aa)
	CALML4	Calmodulin like 4. (196 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
	ASPM	Abnormal spindle microtubule assembly. (3472 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (284 aa)
	FOXG1	Forkhead box G1. (505 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT3	CASP3	ENSCJAP00000031436	ENSCJAP00000010532	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 3; Belongs to the peptidase C14A family.	0.529
AKT3	CASP9	ENSCJAP00000031436	ENSCJAP00000016114	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Caspase 9; Belongs to the peptidase C14A family.	0.955
AKT3	CCND1	ENSCJAP00000031436	ENSCJAP00000053235	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin D1; Belongs to the cyclin family.	0.406
AKT3	CDC42	ENSCJAP00000031436	ENSCJAP00000063033	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cell division control protein 42 homolog isoform 1.	0.527
AKT3	FOXG1	ENSCJAP00000031436	ENSCJAP00000011408	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box G1.	0.495
AKT3	MTOR	ENSCJAP00000031436	ENSCJAP00000004176	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.973
AKT3	PIK3R2	ENSCJAP00000031436	ENSCJAP00000025887	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.969
AKT3	PTEN	ENSCJAP00000031436	ENSCJAP00000054409	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.745
AKT3	RHOG	ENSCJAP00000031436	ENSCJAP00000053721	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Rho-related GTP-binding protein RhoG.	0.464
ASPM	CALM1	ENSCJAP00000008723	ENSCJAP00000059919	Abnormal spindle microtubule assembly.	Uncharacterized protein; Belongs to the calmodulin family.	0.513
ASPM	CALML3	ENSCJAP00000008723	ENSCJAP00000061917	Abnormal spindle microtubule assembly.	Calmodulin-like protein 3; Belongs to the calmodulin family.	0.513
ASPM	CALML5	ENSCJAP00000008723	ENSCJAP00000058230	Abnormal spindle microtubule assembly.	Calmodulin-like protein 5.	0.513
ASPM	CALML6	ENSCJAP00000008723	ENSCJAP00000019916	Abnormal spindle microtubule assembly.	Calmodulin like 6.	0.509
ASPM	CDK6	ENSCJAP00000008723	ENSCJAP00000062161	Abnormal spindle microtubule assembly.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.620
ASPM	CEP120	ENSCJAP00000008723	ENSCJAP00000069746	Abnormal spindle microtubule assembly.	Centrosomal protein of 120 kDa isoform 1.	0.526
ASPM	FOXP2	ENSCJAP00000008723	ENSCJAP00000031433	Abnormal spindle microtubule assembly.	Forkhead box P2.	0.555
ASPM	GPSM2	ENSCJAP00000008723	ENSCJAP00000048830	Abnormal spindle microtubule assembly.	G-protein-signaling modulator 2.	0.501
ASPM	MCPH1	ENSCJAP00000008723	ENSCJAP00000000364	Abnormal spindle microtubule assembly.	Microcephalin isoform 1.	0.963
ASPM	NDE1	ENSCJAP00000008723	ENSCJAP00000072461	Abnormal spindle microtubule assembly.	NudE neurodevelopment protein 1.	0.640
ASPM	SHH	ENSCJAP00000008723	ENSCJAP00000037954	Abnormal spindle microtubule assembly.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.419