node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | FGF21 | ENSCJAP00000074271 | ENSCJAP00000000520 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.409 |
BDNF | FNDC5 | ENSCJAP00000074271 | ENSCJAP00000072388 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Fibronectin type III domain containing 5. | 0.528 |
BDNF | INS | ENSCJAP00000074271 | ENSCJAP00000034117 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.724 |
BDNF | LEP | ENSCJAP00000074271 | ENSCJAP00000032679 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.583 |
BDNF | MTOR | ENSCJAP00000074271 | ENSCJAP00000004176 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.418 |
BDNF | PPARG | ENSCJAP00000074271 | ENSCJAP00000048822 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.503 |
BMP4 | BMP7 | ENSCJAP00000070142 | ENSCJAP00000070399 | Bone morphogenetic protein 4 preproprotein. | Bone morphogenetic protein 7. | 0.824 |
BMP4 | INS | ENSCJAP00000070142 | ENSCJAP00000034117 | Bone morphogenetic protein 4 preproprotein. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.637 |
BMP7 | BMP4 | ENSCJAP00000070399 | ENSCJAP00000070142 | Bone morphogenetic protein 7. | Bone morphogenetic protein 4 preproprotein. | 0.824 |
BMP7 | FGF21 | ENSCJAP00000070399 | ENSCJAP00000000520 | Bone morphogenetic protein 7. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.401 |
BMP7 | FNDC5 | ENSCJAP00000070399 | ENSCJAP00000072388 | Bone morphogenetic protein 7. | Fibronectin type III domain containing 5. | 0.446 |
BMP7 | TMEM26 | ENSCJAP00000070399 | ENSCJAP00000013105 | Bone morphogenetic protein 7. | Transmembrane protein 26. | 0.461 |
BMP7 | UCP1 | ENSCJAP00000070399 | ENSCJAP00000005477 | Bone morphogenetic protein 7. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.478 |
CD36 | FGF21 | ENSCJAP00000005979 | ENSCJAP00000000520 | CD36 molecule; Belongs to the CD36 family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.480 |
CD36 | INS | ENSCJAP00000005979 | ENSCJAP00000034117 | CD36 molecule; Belongs to the CD36 family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.634 |
CD36 | LEP | ENSCJAP00000005979 | ENSCJAP00000032679 | CD36 molecule; Belongs to the CD36 family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.461 |
CD36 | PPARG | ENSCJAP00000005979 | ENSCJAP00000048822 | CD36 molecule; Belongs to the CD36 family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.778 |
CD36 | UCP1 | ENSCJAP00000005979 | ENSCJAP00000005477 | CD36 molecule; Belongs to the CD36 family. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.425 |
CIDEA | FGF21 | ENSCJAP00000008796 | ENSCJAP00000000520 | Cell death inducing DFFA like effector a. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.526 |
CIDEA | INS | ENSCJAP00000008796 | ENSCJAP00000034117 | Cell death inducing DFFA like effector a. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.445 |