STRINGSTRING
IL6 IL6 TNF TNF KIT KIT IGF1 IGF1 IFNG IFNG AGT AGT BCL2 BCL2 TGFB3 TGFB3 RSPO1 RSPO1 LOC100411779 LOC100411779 TLR5 TLR5 ENSCJAP00000076309 ENSCJAP00000076309 FGF2 FGF2 CD34 CD34 EGF EGF IGF1R IGF1R BRCA1 BRCA1 BECN1 BECN1 MDM4 MDM4 BRCA2 BRCA2 ESR1 ESR1 ACE ACE STC1 STC1 SIRT1 SIRT1 LOC100398346 LOC100398346
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL6Interleukin 6. (212 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (232 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (976 aa)
IGF1Insulin like growth factor 1. (197 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. (491 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
TGFB3Transforming growth factor beta 3. (428 aa)
RSPO1R-spondin 1. (281 aa)
LOC100411779Uncharacterized protein. (230 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (869 aa)
ENSCJAP00000076309Angiotensin-converting enzyme. (703 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
CD34Hematopoietic progenitor cell antigen CD34 isoform a. (386 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
IGF1RTyrosine-protein kinase receptor. (1366 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1830 aa)
BECN1Beclin-1. (450 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
BRCA2BRCA2 DNA repair associated. (3409 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
ACEAngiotensin-converting enzyme. (1306 aa)
STC1Stanniocalcin 1. (372 aa)
SIRT1Sirtuin 1. (753 aa)
LOC100398346RAD50 homolog isoform 1 (Predicted). (1312 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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