STRINGSTRING
NOX4 NOX4 THY1 THY1 SRC SRC THBS1 THBS1 CDH2 CDH2 BMP7 BMP7 BMP4 BMP4 HDAC9 HDAC9 HDAC5 HDAC5 PDGFB PDGFB CDC42 CDC42 SMAD7 SMAD7 ZEB2 ZEB2 SMAD4 SMAD4 LUM LUM PPARG PPARG IL6 IL6 CCR1 CCR1 TGFB1 TGFB1 DCN DCN MMP9 MMP9 AKT2 AKT2 RHOA RHOA SNAI2 SNAI2 TGFB2 TGFB2 HDAC7 HDAC7 HDAC4 HDAC4 PLAT PLAT ID2 ID2 SMAD2 SMAD2 EGF EGF CD34 CD34 HGF HGF MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOX4NADPH oxidase 4. (556 aa)
THY1Thy-1 cell surface antigen. (165 aa)
SRCTyrosine-protein kinase. (553 aa)
THBS1Thrombospondin 1. (1178 aa)
CDH2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] (984 aa)
BMP7Bone morphogenetic protein 7. (430 aa)
BMP4Bone morphogenetic protein 4 preproprotein. (408 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1096 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1124 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
CDC42Cell division control protein 42 homolog isoform 1. (191 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1238 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LUMLumican. (338 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
IL6Interleukin 6. (212 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (355 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RHOATransforming protein RhoA. (193 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (990 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1035 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
ID2Inhibitor of DNA binding 2. (203 aa)
SMAD2Mothers against decapentaplegic homolog. (494 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
CD34Hematopoietic progenitor cell antigen CD34 isoform a. (386 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (813 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.