(12 nodes) (2017) A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in ... network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD3	Mothers against decapentaplegic homolog. (437 aa)
	LOC100393688	Creatine kinase, mitochondrial 1A (Predicted); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	ACE	Angiotensin-converting enzyme. (1306 aa)
	CKMT2	Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (419 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	GDF11	Growth differentiation factor 11. (408 aa)
	MSTN	Myostatin. (380 aa)
	SMAD2	Mothers against decapentaplegic homolog. (494 aa)
	FST	Follistatin isoform FST344. (344 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	CKM	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (441 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	GDF11	ENSCJAP00000036755	ENSCJAP00000014653	Angiotensin-converting enzyme.	Growth differentiation factor 11.	0.691
ACE	MSTN	ENSCJAP00000036755	ENSCJAP00000010392	Angiotensin-converting enzyme.	Myostatin.	0.503
CKM	CKMT2	ENSCJAP00000053595	ENSCJAP00000036222	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family.	Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family.	0.974
CKM	LOC100393688	ENSCJAP00000053595	ENSCJAP00000044680	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family.	Creatine kinase, mitochondrial 1A (Predicted); Belongs to the ATP:guanido phosphotransferase family.	0.927
CKMT2	CKM	ENSCJAP00000036222	ENSCJAP00000053595	Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family.	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family.	0.974
CKMT2	LOC100393688	ENSCJAP00000036222	ENSCJAP00000044680	Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family.	Creatine kinase, mitochondrial 1A (Predicted); Belongs to the ATP:guanido phosphotransferase family.	0.964
FST	GDF11	ENSCJAP00000057505	ENSCJAP00000014653	Follistatin isoform FST344.	Growth differentiation factor 11.	0.946
FST	MSTN	ENSCJAP00000057505	ENSCJAP00000010392	Follistatin isoform FST344.	Myostatin.	0.988
FST	SMAD2	ENSCJAP00000057505	ENSCJAP00000008504	Follistatin isoform FST344.	Mothers against decapentaplegic homolog.	0.615
FST	SMAD3	ENSCJAP00000057505	ENSCJAP00000003797	Follistatin isoform FST344.	Mothers against decapentaplegic homolog.	0.477
FST	SMAD4	ENSCJAP00000057505	ENSCJAP00000056533	Follistatin isoform FST344.	Mothers against decapentaplegic homolog.	0.490
FST	TGFB1	ENSCJAP00000057505	ENSCJAP00000037471	Follistatin isoform FST344.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.478
GDF11	ACE	ENSCJAP00000014653	ENSCJAP00000036755	Growth differentiation factor 11.	Angiotensin-converting enzyme.	0.691
GDF11	FST	ENSCJAP00000014653	ENSCJAP00000057505	Growth differentiation factor 11.	Follistatin isoform FST344.	0.946
GDF11	SMAD2	ENSCJAP00000014653	ENSCJAP00000008504	Growth differentiation factor 11.	Mothers against decapentaplegic homolog.	0.693
GDF11	SMAD3	ENSCJAP00000014653	ENSCJAP00000003797	Growth differentiation factor 11.	Mothers against decapentaplegic homolog.	0.651
GDF11	SMAD4	ENSCJAP00000014653	ENSCJAP00000056533	Growth differentiation factor 11.	Mothers against decapentaplegic homolog.	0.662
LOC100393688	CKM	ENSCJAP00000044680	ENSCJAP00000053595	Creatine kinase, mitochondrial 1A (Predicted); Belongs to the ATP:guanido phosphotransferase family.	Creatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family.	0.927
LOC100393688	CKMT2	ENSCJAP00000044680	ENSCJAP00000036222	Creatine kinase, mitochondrial 1A (Predicted); Belongs to the ATP:guanido phosphotransferase family.	Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family.	0.964
MSTN	ACE	ENSCJAP00000010392	ENSCJAP00000036755	Myostatin.	Angiotensin-converting enzyme.	0.503