node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALK | EML4 | ENSCJAP00000016156 | ENSCJAP00000027215 | Tyrosine-protein kinase receptor. | EMAP like 4. | 0.995 |
ALK | KRAS | ENSCJAP00000016156 | ENSCJAP00000054102 | Tyrosine-protein kinase receptor. | KRAS proto-oncogene, GTPase. | 0.681 |
ALK | PTEN | ENSCJAP00000016156 | ENSCJAP00000054409 | Tyrosine-protein kinase receptor. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.566 |
ALK | TP53 | ENSCJAP00000016156 | ENSCJAP00000066800 | Tyrosine-protein kinase receptor. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.467 |
BRCA1 | BRCA2 | ENSCJAP00000023883 | ENSCJAP00000034250 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | BRCA2 DNA repair associated. | 0.999 |
BRCA1 | KRAS | ENSCJAP00000023883 | ENSCJAP00000054102 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | KRAS proto-oncogene, GTPase. | 0.435 |
BRCA1 | PTEN | ENSCJAP00000023883 | ENSCJAP00000054409 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.609 |
BRCA1 | TP53 | ENSCJAP00000023883 | ENSCJAP00000066800 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.746 |
BRCA2 | BRCA1 | ENSCJAP00000034250 | ENSCJAP00000023883 | BRCA2 DNA repair associated. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.999 |
BRCA2 | KRAS | ENSCJAP00000034250 | ENSCJAP00000054102 | BRCA2 DNA repair associated. | KRAS proto-oncogene, GTPase. | 0.492 |
BRCA2 | PTEN | ENSCJAP00000034250 | ENSCJAP00000054409 | BRCA2 DNA repair associated. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.668 |
BRCA2 | TP53 | ENSCJAP00000034250 | ENSCJAP00000066800 | BRCA2 DNA repair associated. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.760 |
EML4 | ALK | ENSCJAP00000027215 | ENSCJAP00000016156 | EMAP like 4. | Tyrosine-protein kinase receptor. | 0.995 |
EML4 | KRAS | ENSCJAP00000027215 | ENSCJAP00000054102 | EMAP like 4. | KRAS proto-oncogene, GTPase. | 0.475 |
EML4 | PTEN | ENSCJAP00000027215 | ENSCJAP00000054409 | EMAP like 4. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.460 |
KRAS | ALK | ENSCJAP00000054102 | ENSCJAP00000016156 | KRAS proto-oncogene, GTPase. | Tyrosine-protein kinase receptor. | 0.681 |
KRAS | BRCA1 | ENSCJAP00000054102 | ENSCJAP00000023883 | KRAS proto-oncogene, GTPase. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.435 |
KRAS | BRCA2 | ENSCJAP00000054102 | ENSCJAP00000034250 | KRAS proto-oncogene, GTPase. | BRCA2 DNA repair associated. | 0.492 |
KRAS | EML4 | ENSCJAP00000054102 | ENSCJAP00000027215 | KRAS proto-oncogene, GTPase. | EMAP like 4. | 0.475 |
KRAS | PTEN | ENSCJAP00000054102 | ENSCJAP00000054409 | KRAS proto-oncogene, GTPase. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | 0.686 |