(9 nodes) (2019) Involvement of PRRSV NSP3 and NSP5 in the autophagy process. network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ALB	Albumin. (608 aa)
	CANX	Calnexin. (592 aa)
	XBP1	BZIP domain-containing protein. (371 aa)
	ATG16L1	Autophagy related 16 like 1. (633 aa)
	ENSCJAP00000059748	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (195 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	LAMP1	Lysosomal associated membrane protein 1. (449 aa)
	DDIT3	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (169 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	CANX	ENSCJAP00000025792	ENSCJAP00000018554	Albumin.	Calnexin.	0.530
ALB	LAMP1	ENSCJAP00000025792	ENSCJAP00000055138	Albumin.	Lysosomal associated membrane protein 1.	0.537
ATG12	ATG16L1	ENSCJAP00000059203	ENSCJAP00000077866	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 16 like 1.	0.999
ATG12	ATG5	ENSCJAP00000059203	ENSCJAP00000011649	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	LAMP1	ENSCJAP00000059203	ENSCJAP00000055138	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Lysosomal associated membrane protein 1.	0.642
ATG12	XBP1	ENSCJAP00000059203	ENSCJAP00000037339	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	BZIP domain-containing protein.	0.448
ATG16L1	ATG12	ENSCJAP00000077866	ENSCJAP00000059203	Autophagy related 16 like 1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG16L1	ATG5	ENSCJAP00000077866	ENSCJAP00000011649	Autophagy related 16 like 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG16L1	LAMP1	ENSCJAP00000077866	ENSCJAP00000055138	Autophagy related 16 like 1.	Lysosomal associated membrane protein 1.	0.418
ATG5	ATG12	ENSCJAP00000011649	ENSCJAP00000059203	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG16L1	ENSCJAP00000011649	ENSCJAP00000077866	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy related 16 like 1.	0.999
ATG5	CANX	ENSCJAP00000011649	ENSCJAP00000018554	Autophagy protein 5; Involved in autophagic vesicle formation.	Calnexin.	0.415
ATG5	LAMP1	ENSCJAP00000011649	ENSCJAP00000055138	Autophagy protein 5; Involved in autophagic vesicle formation.	Lysosomal associated membrane protein 1.	0.791
ATG5	XBP1	ENSCJAP00000011649	ENSCJAP00000037339	Autophagy protein 5; Involved in autophagic vesicle formation.	BZIP domain-containing protein.	0.523
CANX	ALB	ENSCJAP00000018554	ENSCJAP00000025792	Calnexin.	Albumin.	0.530
CANX	ATG5	ENSCJAP00000018554	ENSCJAP00000011649	Calnexin.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.415
CANX	LAMP1	ENSCJAP00000018554	ENSCJAP00000055138	Calnexin.	Lysosomal associated membrane protein 1.	0.613
CANX	XBP1	ENSCJAP00000018554	ENSCJAP00000037339	Calnexin.	BZIP domain-containing protein.	0.610
DDIT3	ENSCJAP00000059748	ENSCJAP00000043609	ENSCJAP00000059748	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.900
DDIT3	XBP1	ENSCJAP00000043609	ENSCJAP00000037339	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	BZIP domain-containing protein.	0.982