(32 nodes) (2019) Genetics of scapula and pelvis development: An evolutionary perspective. network (Callithrix jacchus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	TBX15	T-box transcription factor 15. (602 aa)
	EMX2	Homeobox protein EMX2 isoform 1. (252 aa)
	LMX1B	LIM homeobox transcription factor 1 beta. (402 aa)
	PBX2	PBX homeobox 2. (431 aa)
	PBX1	Pre-B-cell leukemia transcription factor 1 isoform 1. (430 aa)
	PAX1	Paired box 1. (454 aa)
	PBX3	Pre-B-cell leukemia transcription factor 3 isoform 1. (434 aa)
	HOXB5	Homeobox B5. (269 aa)
	GLI3	GLI family zinc finger 3. (1578 aa)
	HOXA5	Homeobox A5 (Predicted). (270 aa)
	TBX5	T-box transcription factor TBX5 isoform 1. (518 aa)
	MSX1	Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
	PAX3	Uncharacterized protein. (484 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	GDF5	Growth differentiation factor 5. (501 aa)
	HOXC6	Homeobox C6. (290 aa)
	MYF6	Myogenic factor 6. (242 aa)
	ALX1	ALX homeobox 1. (326 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
	MYF5	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
	GDF6	Growth differentiation factor 6. (454 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	TBX4	T-box transcription factor TBX4. (545 aa)
	ALX3	ALX homeobox 3. (462 aa)
	SOX10	Transcription factor SOX-10. (467 aa)
	BMP5	Bone morphogenetic protein 5. (472 aa)
	FGFR1	Fibroblast growth factor receptor. (885 aa)
	TWIST1	Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...] (203 aa)
	PITX1	Homeobox protein. (314 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	HOXC10	Homeobox C10. (347 aa)
	HOXD12	Homeobox D12. (270 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX1	BMP5	ENSCJAP00000036128	ENSCJAP00000073771	ALX homeobox 1.	Bone morphogenetic protein 5.	0.521
ALX1	GDF5	ENSCJAP00000036128	ENSCJAP00000032881	ALX homeobox 1.	Growth differentiation factor 5.	0.533
ALX1	GDF6	ENSCJAP00000036128	ENSCJAP00000052478	ALX homeobox 1.	Growth differentiation factor 6.	0.638
ALX1	GLI3	ENSCJAP00000036128	ENSCJAP00000014298	ALX homeobox 1.	GLI family zinc finger 3.	0.459
ALX1	MYF5	ENSCJAP00000036128	ENSCJAP00000048696	ALX homeobox 1.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.449
ALX1	MYF6	ENSCJAP00000036128	ENSCJAP00000035903	ALX homeobox 1.	Myogenic factor 6.	0.625
ALX1	PBX1	ENSCJAP00000036128	ENSCJAP00000008611	ALX homeobox 1.	Pre-B-cell leukemia transcription factor 1 isoform 1.	0.524
ALX1	PBX2	ENSCJAP00000036128	ENSCJAP00000003408	ALX homeobox 1.	PBX homeobox 2.	0.659
ALX1	PBX3	ENSCJAP00000036128	ENSCJAP00000013069	ALX homeobox 1.	Pre-B-cell leukemia transcription factor 3 isoform 1.	0.553
ALX1	TBX15	ENSCJAP00000036128	ENSCJAP00000059788	ALX homeobox 1.	T-box transcription factor 15.	0.631
ALX1	TBX4	ENSCJAP00000036128	ENSCJAP00000002267	ALX homeobox 1.	T-box transcription factor TBX4.	0.457
ALX1	TWIST1	ENSCJAP00000036128	ENSCJAP00000072433	ALX homeobox 1.	Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...]	0.448
ALX3	GLI3	ENSCJAP00000075645	ENSCJAP00000014298	ALX homeobox 3.	GLI family zinc finger 3.	0.403
ALX3	PBX1	ENSCJAP00000075645	ENSCJAP00000008611	ALX homeobox 3.	Pre-B-cell leukemia transcription factor 1 isoform 1.	0.437
ALX3	TBX15	ENSCJAP00000075645	ENSCJAP00000059788	ALX homeobox 3.	T-box transcription factor 15.	0.592
ALX3	TBX4	ENSCJAP00000075645	ENSCJAP00000002267	ALX homeobox 3.	T-box transcription factor TBX4.	0.422
ALX3	TWIST1	ENSCJAP00000075645	ENSCJAP00000072433	ALX homeobox 3.	Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...]	0.414
BMP5	ALX1	ENSCJAP00000073771	ENSCJAP00000036128	Bone morphogenetic protein 5.	ALX homeobox 1.	0.521
BMP5	GDF5	ENSCJAP00000073771	ENSCJAP00000032881	Bone morphogenetic protein 5.	Growth differentiation factor 5.	0.416
BMP5	GDF6	ENSCJAP00000073771	ENSCJAP00000052478	Bone morphogenetic protein 5.	Growth differentiation factor 6.	0.406