STRINGSTRING
EZH2 EZH2 PPY PPY SOX17 SOX17 DYRK1A DYRK1A RETN RETN RETNLB RETNLB SOX9 SOX9 CDKN1A CDKN1A ST8SIA1 ST8SIA1 FOXA1 FOXA1 MNX1 MNX1 PAX6 PAX6 SERPINB1 SERPINB1 INSR INSR GATA4 GATA4 GPHN GPHN CDK5 CDK5 IL10 IL10 INS INS CCNA1 CCNA1 PAX4 PAX4 GHRL GHRL MYC MYC NEUROD1 NEUROD1 ISL1 ISL1 PTF1A PTF1A PRL PRL GCG GCG FOXA2 FOXA2 PAX1 PAX1 CASP8 CASP8 RFX6 RFX6 CCNA2 CCNA2 MTOR MTOR CD9 CD9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
PPYPancreatic polypeptide. (154 aa)
SOX17SRY-box transcription factor 17. (414 aa)
DYRK1ADual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1. (763 aa)
RETNResistin. (127 aa)
RETNLBUncharacterized protein. (111 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (158 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (467 aa)
MNX1Motor neuron and pancreas homeobox 1. (399 aa)
PAX6Paired box 6. (472 aa)
SERPINB1Serpin family B member 1; Belongs to the serpin family. (463 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
GATA4GATA binding protein 4. (442 aa)
GPHNMolybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. (782 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (306 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
PAX4Paired box 4. (350 aa)
GHRLAppetite-regulating hormone isoform 1 preproprotein. (117 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
PTF1APancreas associated transcription factor 1a. (332 aa)
PRLGrowth hormone A1. (227 aa)
GCGGlucagon. (263 aa)
FOXA2Forkhead box A2. (456 aa)
PAX1Paired box 1. (454 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (479 aa)
RFX6Regulatory factor X6. (928 aa)
CCNA2Cyclin-A2; Belongs to the cyclin family. (432 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CD9Tetraspanin. (228 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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