(29 nodes) (2019) Amelioration of Huntingtons disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntingtons disease monkeys. network (Callithrix jacchus)

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Your Input:
	SOD2	Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (318 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (915 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (400 aa)
	NES	Nestin; Belongs to the intermediate filament family. (1717 aa)
	GRM1	Metabotropic glutamate receptor 1 isoform alpha. (1194 aa)
	GRM5	Metabotropic glutamate receptor 5 isoform a. (1210 aa)
	CASP3	Caspase 3; Belongs to the peptidase C14A family. (284 aa)
	MAP2	Microtubule-associated protein. (1945 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
	BMP2	Bone morphogenetic protein 2. (401 aa)
	CCL5	C-C motif chemokine. (91 aa)
	HTT	Huntingtin. (3127 aa)
	POU5F1	POU-specific domain-containing protein. (484 aa)
	ALDH1L1	Aldehyde dehydrogenase 1 family member L1; Belongs to the aldehyde dehydrogenase family. (944 aa)
	FOXO4	Forkhead box O4. (508 aa)
	TH	Tyrosine hydroxylase. (623 aa)
	FZD1	Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (580 aa)
	GAD1	Glutamate decarboxylase 1. (710 aa)
	BCL2	BCL2 apoptosis regulator. (240 aa)
	CASP2	Caspase-2 isoform 1 preproprotein; Belongs to the peptidase C14A family. (452 aa)
	CXCR1	C-X-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	PAX6	Paired box 6. (472 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
	SOX2	Transcription factor SOX-2. (319 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (883 aa)
	BCL2L1	Bcl-2-like protein 1 isoform 1. (233 aa)
	LCN2	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (412 aa)
	POU5F1-2	Uncharacterized protein. (146 aa)
	APOE	Apolipoprotein E. (320 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH1L1	GAD1	ENSCJAP00000070610	ENSCJAP00000066747	Aldehyde dehydrogenase 1 family member L1; Belongs to the aldehyde dehydrogenase family.	Glutamate decarboxylase 1.	0.495
APOE	BCL2	ENSCJAP00000023984	ENSCJAP00000066653	Apolipoprotein E.	BCL2 apoptosis regulator.	0.406
APOE	BDNF	ENSCJAP00000023984	ENSCJAP00000074271	Apolipoprotein E.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.628
APOE	CASP3	ENSCJAP00000023984	ENSCJAP00000010532	Apolipoprotein E.	Caspase 3; Belongs to the peptidase C14A family.	0.573
APOE	MAP2	ENSCJAP00000023984	ENSCJAP00000074988	Apolipoprotein E.	Microtubule-associated protein.	0.533
APOE	PPARG	ENSCJAP00000023984	ENSCJAP00000048822	Apolipoprotein E.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.667
BCL2	APOE	ENSCJAP00000066653	ENSCJAP00000023984	BCL2 apoptosis regulator.	Apolipoprotein E.	0.406
BCL2	BCL2L1	ENSCJAP00000066653	ENSCJAP00000038660	BCL2 apoptosis regulator.	Bcl-2-like protein 1 isoform 1.	0.930
BCL2	BDNF	ENSCJAP00000066653	ENSCJAP00000074271	BCL2 apoptosis regulator.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.820
BCL2	CASP2	ENSCJAP00000066653	ENSCJAP00000064733	BCL2 apoptosis regulator.	Caspase-2 isoform 1 preproprotein; Belongs to the peptidase C14A family.	0.621
BCL2	CASP3	ENSCJAP00000066653	ENSCJAP00000010532	BCL2 apoptosis regulator.	Caspase 3; Belongs to the peptidase C14A family.	0.963
BCL2	CASP9	ENSCJAP00000066653	ENSCJAP00000016114	BCL2 apoptosis regulator.	Caspase 9; Belongs to the peptidase C14A family.	0.943
BCL2	PPARG	ENSCJAP00000066653	ENSCJAP00000048822	BCL2 apoptosis regulator.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.568
BCL2	SOD2	ENSCJAP00000066653	ENSCJAP00000021521	BCL2 apoptosis regulator.	Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.488
BCL2	TH	ENSCJAP00000066653	ENSCJAP00000068563	BCL2 apoptosis regulator.	Tyrosine hydroxylase.	0.439
BCL2L1	BCL2	ENSCJAP00000038660	ENSCJAP00000066653	Bcl-2-like protein 1 isoform 1.	BCL2 apoptosis regulator.	0.930
BCL2L1	CASP2	ENSCJAP00000038660	ENSCJAP00000064733	Bcl-2-like protein 1 isoform 1.	Caspase-2 isoform 1 preproprotein; Belongs to the peptidase C14A family.	0.701
BCL2L1	CASP3	ENSCJAP00000038660	ENSCJAP00000010532	Bcl-2-like protein 1 isoform 1.	Caspase 3; Belongs to the peptidase C14A family.	0.831
BCL2L1	CASP9	ENSCJAP00000038660	ENSCJAP00000016114	Bcl-2-like protein 1 isoform 1.	Caspase 9; Belongs to the peptidase C14A family.	0.950
BDNF	APOE	ENSCJAP00000074271	ENSCJAP00000023984	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	Apolipoprotein E.	0.628