STRINGSTRING
KLF5 KLF5 IL6 IL6 KRT8 KRT8 IRF1 IRF1 OTX2 OTX2 IFNG IFNG SPAM1 SPAM1 SOX2 SOX2 STAT3 STAT3 SALL4 SALL4 EPCAM EPCAM KLF17 KLF17 PDGFA PDGFA WNT2 WNT2 HYAL3 HYAL3 NR5A2 NR5A2 HYAL1 HYAL1 GTF3C1 GTF3C1 FGFR4 FGFR4 DAB2 DAB2 LIFR LIFR NCOA1 NCOA1 PRDM14 PRDM14 SALL2 SALL2 TBX3 TBX3 LIN28A LIN28A MYC MYC MCM4 MCM4 ZIC3 ZIC3 NODAL NODAL JAK1 JAK1 DLK1 DLK1 HYAL4 HYAL4 PDGFRA PDGFRA NANOG NANOG POU5F1-2 POU5F1-2 KLF4 KLF4 TLR3 TLR3 TFCP2L1 TFCP2L1 GP2 GP2 POU5F1 POU5F1 TFAP2C TFAP2C ESRRB ESRRB IL7 IL7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLF5Krueppel-like factor 5. (457 aa)
IL6Interleukin 6. (212 aa)
KRT8IF rod domain-containing protein; Belongs to the intermediate filament family. (482 aa)
IRF1Interferon regulatory factor. (324 aa)
OTX2Uncharacterized protein. (35 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
SPAM1Hyaluronidase. (509 aa)
SOX2Transcription factor SOX-2. (319 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
SALL4Uncharacterized protein. (986 aa)
EPCAMEpithelial cell adhesion molecule. (173 aa)
KLF17Kruppel like factor 17. (414 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (443 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
HYAL3Hyaluronidase. (417 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
HYAL1Hyaluronidase. (780 aa)
GTF3C1General transcription factor IIIC subunit 1. (2102 aa)
FGFR4Fibroblast growth factor receptor. (801 aa)
DAB2Disabled homolog 2 isoform 1. (767 aa)
LIFRLIF receptor subunit alpha. (1105 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
PRDM14Uncharacterized protein. (571 aa)
SALL2Spalt like transcription factor 2. (1009 aa)
TBX3T-box transcription factor TBX3 isoform 2. (743 aa)
LIN28ALin-28 homolog A. (209 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
MCM4DNA helicase; Belongs to the MCM family. (955 aa)
ZIC3Zinc finger protein ZIC 3. (467 aa)
NODALNodal growth differentiation factor. (346 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
DLK1Uncharacterized protein. (713 aa)
HYAL4Hyaluronidase. (481 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
NANOGHomeobox domain-containing protein. (305 aa)
POU5F1-2Uncharacterized protein. (146 aa)
KLF4Kruppel like factor 4. (507 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
TFCP2L1Transcription factor CP2 like 1. (612 aa)
GP2Glycoprotein 2. (528 aa)
POU5F1POU-specific domain-containing protein. (484 aa)
TFAP2CTranscription factor AP-2 gamma. (548 aa)
ESRRBEstrogen related receptor beta. (454 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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