(28 nodes) (2021) Running the full human developmental clock in interspecies chimeras using alternative human stem cells with expanded embryonic potential. network (Callithrix jacchus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	FOXA2	Forkhead box A2. (456 aa)
	RUNX1	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
	STAT3	Signal transducer and activator of transcription. (771 aa)
	CD34	Hematopoietic progenitor cell antigen CD34 isoform a. (386 aa)
	ENSCJAP00000076309	Angiotensin-converting enzyme. (703 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	POU5F1	POU-specific domain-containing protein. (484 aa)
	PXDN	Uncharacterized protein. (691 aa)
	BMP4	Bone morphogenetic protein 4 preproprotein. (408 aa)
	GATA1	GATA binding protein 1. (413 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1252 aa)
	LCOR	Uncharacterized protein. (1551 aa)
	GATA2	Endothelial transcription factor GATA-2 isoform 1. (480 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	POU5F1-2	Uncharacterized protein. (146 aa)
	ACE	Angiotensin-converting enzyme. (1306 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	PXDNL	Peroxidasin like. (1457 aa)
	SST	Somatostatin preproprotein. (116 aa)
	AFP	Alpha fetoprotein. (609 aa)
	VTN	SMB domain-containing protein. (458 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1325 aa)
	CXCR4	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (352 aa)
	CDX4	Caudal type homeobox 4. (284 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1166 aa)
	HOXA5	Homeobox A5 (Predicted). (270 aa)
	HOXB4	Homeobox B4. (252 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	CDX4	ENSCJAP00000036755	ENSCJAP00000020910	Angiotensin-converting enzyme.	Caudal type homeobox 4.	0.481
ACE	INS	ENSCJAP00000036755	ENSCJAP00000034117	Angiotensin-converting enzyme.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.697
AFP	BMP4	ENSCJAP00000025703	ENSCJAP00000070142	Alpha fetoprotein.	Bone morphogenetic protein 4 preproprotein.	0.451
AFP	CD34	ENSCJAP00000025703	ENSCJAP00000006891	Alpha fetoprotein.	Hematopoietic progenitor cell antigen CD34 isoform a.	0.415
AFP	FOXA2	ENSCJAP00000025703	ENSCJAP00000010628	Alpha fetoprotein.	Forkhead box A2.	0.493
AFP	INS	ENSCJAP00000025703	ENSCJAP00000034117	Alpha fetoprotein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.594
AFP	POU5F1	ENSCJAP00000025703	ENSCJAP00000071643	Alpha fetoprotein.	POU-specific domain-containing protein.	0.552
AFP	POU5F1-2	ENSCJAP00000025703	ENSCJAP00000036806	Alpha fetoprotein.	Uncharacterized protein.	0.552
AFP	VTN	ENSCJAP00000025703	ENSCJAP00000023190	Alpha fetoprotein.	SMB domain-containing protein.	0.511
BMP4	AFP	ENSCJAP00000070142	ENSCJAP00000025703	Bone morphogenetic protein 4 preproprotein.	Alpha fetoprotein.	0.451
BMP4	CD34	ENSCJAP00000070142	ENSCJAP00000006891	Bone morphogenetic protein 4 preproprotein.	Hematopoietic progenitor cell antigen CD34 isoform a.	0.527
BMP4	CXCR4	ENSCJAP00000070142	ENSCJAP00000022127	Bone morphogenetic protein 4 preproprotein.	C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...]	0.402
BMP4	FOXA2	ENSCJAP00000070142	ENSCJAP00000010628	Bone morphogenetic protein 4 preproprotein.	Forkhead box A2.	0.555
BMP4	GATA2	ENSCJAP00000070142	ENSCJAP00000038400	Bone morphogenetic protein 4 preproprotein.	Endothelial transcription factor GATA-2 isoform 1.	0.406
BMP4	INS	ENSCJAP00000070142	ENSCJAP00000034117	Bone morphogenetic protein 4 preproprotein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.637
BMP4	POU5F1	ENSCJAP00000070142	ENSCJAP00000071643	Bone morphogenetic protein 4 preproprotein.	POU-specific domain-containing protein.	0.726
BMP4	POU5F1-2	ENSCJAP00000070142	ENSCJAP00000036806	Bone morphogenetic protein 4 preproprotein.	Uncharacterized protein.	0.726
BMP4	RUNX1	ENSCJAP00000070142	ENSCJAP00000005127	Bone morphogenetic protein 4 preproprotein.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.524
BMP4	SHH	ENSCJAP00000070142	ENSCJAP00000037954	Bone morphogenetic protein 4 preproprotein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.736
BMP4	STAT3	ENSCJAP00000070142	ENSCJAP00000000719	Bone morphogenetic protein 4 preproprotein.	Signal transducer and activator of transcription.	0.409