STRINGSTRING
DRD5 DRD5 WNT1 WNT1 SHH SHH POU5F1-2 POU5F1-2 CORIN CORIN E2F1 E2F1 INS INS FGF8 FGF8 HMGCR HMGCR GHRL GHRL IL1B IL1B RET RET MYC MYC FGF20 FGF20 MSX1 MSX1 SFRP1 SFRP1 LIF LIF GDNF GDNF GLI1 GLI1 PINK1 PINK1 CASP3 CASP3 DAPK1 DAPK1 LMX1A LMX1A EGF EGF NEUROG2 NEUROG2 PARK7 PARK7 HDAC1 HDAC1 FGF2 FGF2 KLF4 KLF4 BDNF BDNF POU5F1 POU5F1 TGFB3 TGFB3 BCL2 BCL2 GBX2 GBX2 LMX1B LMX1B OTX2 OTX2 IFNG IFNG IGF1 IGF1 NOG NOG ASCL1 ASCL1 IL6 IL6 DRD3 DRD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (476 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
POU5F1-2Uncharacterized protein. (146 aa)
CORINCorin, serine peptidase. (1042 aa)
E2F1E2F transcription factor 1. (439 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
GHRLAppetite-regulating hormone isoform 1 preproprotein. (117 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1115 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
SFRP1Secreted frizzled-related protein 1. (314 aa)
LIFLIF interleukin 6 family cytokine. (241 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
GLI1GLI family zinc finger 1. (1106 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (284 aa)
DAPK1Death-associated protein kinase 1. (1430 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
NEUROG2Neurogenin 2. (272 aa)
PARK7Protein DJ-1. (189 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (326 aa)
KLF4Kruppel like factor 4. (507 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
POU5F1POU-specific domain-containing protein. (484 aa)
TGFB3Transforming growth factor beta 3. (428 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
LMX1BLIM homeobox transcription factor 1 beta. (402 aa)
OTX2Uncharacterized protein. (35 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
IGF1Insulin like growth factor 1. (197 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (232 aa)
IL6Interleukin 6. (212 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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