STRINGSTRING
MAOB MAOB KLF4 KLF4 BDNF BDNF SRC SRC PRKN PRKN POU5F1 POU5F1 BMP4 BMP4 TH TH SOX9 SOX9 FOXA1 FOXA1 MEF2C MEF2C LMX1B LMX1B OTX2 OTX2 IFNG IFNG EN1 EN1 MAOA MAOA FOSL2 FOSL2 PPARG PPARG SOX2 SOX2 IL6 IL6 MTOR MTOR TARDBP TARDBP HDAC6 HDAC6 LMX1A LMX1A CASP3 CASP3 FOXA2 FOXA2 PINK1 PINK1 ADARB2 ADARB2 SOD1 SOD1 LIF LIF MSX1 MSX1 MYC MYC BACE1 BACE1 CSF2 CSF2 PSEN1 PSEN1 CROT CROT LPGAT1 LPGAT1 PLPP3 PLPP3 NFIA NFIA WNT7A WNT7A FGF8 FGF8 PITX3 PITX3 NR3C1 NR3C1 LOC100397351 LOC100397351 POU5F1-2 POU5F1-2 SHH SHH IL34 IL34 ATP6V1A ATP6V1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAOBAmine oxidase. (520 aa)
KLF4Kruppel like factor 4. (507 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (330 aa)
SRCTyrosine-protein kinase. (553 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (476 aa)
POU5F1POU-specific domain-containing protein. (484 aa)
BMP4Bone morphogenetic protein 4 preproprotein. (408 aa)
THTyrosine hydroxylase. (623 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (467 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform 3. (483 aa)
LMX1BLIM homeobox transcription factor 1 beta. (402 aa)
OTX2Uncharacterized protein. (35 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
EN1Homeobox protein engrailed-like. (391 aa)
MAOAAmine oxidase. (930 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
SOX2Transcription factor SOX-2. (319 aa)
IL6Interleukin 6. (212 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TARDBPTAR DNA-binding protein 43. (414 aa)
HDAC6Histone deacetylase 6. (1254 aa)
LMX1ALIM homeobox transcription factor 1 alpha. (382 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (284 aa)
FOXA2Forkhead box A2. (456 aa)
PINK1Serine/threonine-protein kinase PINK1, mitochondrial. (581 aa)
ADARB2Adenosine deaminase RNA specific B2 (inactive). (709 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
LIFLIF interleukin 6 family cytokine. (241 aa)
MSX1Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis (By similarity). (303 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
BACE1Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family. (501 aa)
CSF2Colony stimulating factor 2 (Predicted). (144 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
CROTPeroxisomal carnitine O-octanoyltransferase isoform 2; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (401 aa)
PLPP3Lipid phosphate phosphohydrolase 3. (311 aa)
NFIANuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (554 aa)
WNT7AProtein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal [...] (349 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PITX3Homeobox protein. (302 aa)
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (778 aa)
LOC100397351Uncharacterized protein. (372 aa)
POU5F1-2Uncharacterized protein. (146 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
IL34Interleukin 34. (242 aa)
ATP6V1AV-type proton ATPase catalytic subunit A. (617 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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