STRINGSTRING
INSR INSR CYP2C8-2 CYP2C8-2 SLX1A SLX1A CXCL1 CXCL1 TLR4 TLR4 ENSCJAP00000068201 ENSCJAP00000068201 TERT TERT IL7 IL7 AGT AGT IFNG IFNG CYP3A21 CYP3A21 SIRT1 SIRT1 CXCL2 CXCL2 CYP2D19 CYP2D19 CYP2E1 CYP2E1 MTOR MTOR STAT3 STAT3 FGF21 FGF21 NOS3 NOS3 CYP2B6 CYP2B6 UGT2A3 UGT2A3 IL10 IL10 INS INS LGALS3 LGALS3 CYP1A2 CYP1A2 IL18 IL18 NOS2 NOS2 LOC100391186 LOC100391186 CASP1 CASP1 CASP9 CASP9 PLAT PLAT NFKBIA NFKBIA CASP3 CASP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INSRTyrosine-protein kinase receptor. (1382 aa)
CYP2C8-2Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
SLX1ASulfotransferase; Belongs to the sulfotransferase 1 family. (358 aa)
CXCL1C-X-C motif chemokine. (107 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (838 aa)
ENSCJAP00000068201Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (964 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (287 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (177 aa)
AGTAngiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family. (491 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
CYP3A21Cytochrome P450 3A21; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (527 aa)
SIRT1Sirtuin 1. (753 aa)
CXCL2C-X-C motif chemokine. (109 aa)
CYP2D19Cytochrome P450 2D19; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. (497 aa)
CYP2E1Uncharacterized protein; Belongs to the cytochrome P450 family. (528 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)
CYP2B6Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (491 aa)
UGT2A3UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
LGALS3Galectin. (248 aa)
CYP1A2Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] (516 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
LOC100391186UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (426 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (400 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
NFKBIANF-kappa-B inhibitor alpha. (310 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (284 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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