(38 nodes) (2022) Single-cell RNA sequencing in oral science: Current awareness and perspectives. network (Callithrix jacchus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CXCL14	C-X-C motif chemokine ligand 14. (191 aa)
	CXCL13	C-X-C motif chemokine ligand 13. (104 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	ACE2	Angiotensin I converting enzyme 2. (844 aa)
	TWIST1	Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...] (203 aa)
	BMP4	Bone morphogenetic protein 4 preproprotein. (408 aa)
	ICOS	Inducible T cell costimulator. (211 aa)
	THBD	Thrombomodulin. (571 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (509 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
	FOXP3	Forkhead box P3. (478 aa)
	TCF7	Transcription factor 7. (512 aa)
	S100A13	S100 calcium binding protein A13; Belongs to the S-100 family. (92 aa)
	FAP	Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa)
	C1R	Complement C1r; Belongs to the peptidase S1 family. (721 aa)
	KRT15	Keratin 15; Belongs to the intermediate filament family. (455 aa)
	C1S	Complement C1s subcomponent; Belongs to the peptidase S1 family. (688 aa)
	LAG3	Lymphocyte activating 3. (525 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	S100A6	Protein S100; Belongs to the S-100 family. (90 aa)
	FURIN	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (795 aa)
	TNFRSF21	Tumor necrosis factor receptor superfamily member 21. (655 aa)
	IL10RA	Interleukin 10 receptor subunit alpha. (579 aa)
	SNAI2	Snail family transcriptional repressor 2. (268 aa)
	AREG	Amphiregulin. (275 aa)
	AMBN	Ameloblastin. (446 aa)
	CCNB1	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (429 aa)
	CXCL12	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	RYR2	Ryanodine receptor 2. (4957 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (477 aa)
	TGFBI	Transforming growth factor-beta-induced protein ig-h3. (682 aa)
	CD4	Ig-like domain-containing protein. (457 aa)
	SNAI1	Snail family transcriptional repressor 1. (264 aa)
	PLAU	Plasminogen activator, urokinase. (443 aa)
	NOTCH3	Notch receptor 3. (2319 aa)
	CCNA2	Cyclin-A2; Belongs to the cyclin family. (432 aa)
	PRDX1	Peroxiredoxin-1. (199 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	CD4	ENSCJAP00000073088	ENSCJAP00000043597	Angiotensin I converting enzyme 2.	Ig-like domain-containing protein.	0.759
ACE2	FURIN	ENSCJAP00000073088	ENSCJAP00000017961	Angiotensin I converting enzyme 2.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.910
ACE2	IFNG	ENSCJAP00000073088	ENSCJAP00000056963	Angiotensin I converting enzyme 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.770
BMP4	SHH	ENSCJAP00000070142	ENSCJAP00000037954	Bone morphogenetic protein 4 preproprotein.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.736
BMP4	SOX9	ENSCJAP00000070142	ENSCJAP00000067837	Bone morphogenetic protein 4 preproprotein.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.446
C1R	C1S	ENSCJAP00000045806	ENSCJAP00000013126	Complement C1r; Belongs to the peptidase S1 family.	Complement C1s subcomponent; Belongs to the peptidase S1 family.	0.999
C1S	C1R	ENSCJAP00000013126	ENSCJAP00000045806	Complement C1s subcomponent; Belongs to the peptidase S1 family.	Complement C1r; Belongs to the peptidase S1 family.	0.999
CCNA2	CCNB1	ENSCJAP00000005501	ENSCJAP00000029608	Cyclin-A2; Belongs to the cyclin family.	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family.	0.860
CCNA2	CKS2	ENSCJAP00000005501	ENSCJAP00000014462	Cyclin-A2; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.848
CCNB1	CCNA2	ENSCJAP00000029608	ENSCJAP00000005501	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family.	Cyclin-A2; Belongs to the cyclin family.	0.860
CCNB1	CKS2	ENSCJAP00000029608	ENSCJAP00000014462	G2/mitotic-specific cyclin-B1; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.858
CD4	ACE2	ENSCJAP00000043597	ENSCJAP00000073088	Ig-like domain-containing protein.	Angiotensin I converting enzyme 2.	0.759
CD4	CTLA4	ENSCJAP00000043597	ENSCJAP00000064098	Ig-like domain-containing protein.	Cytotoxic T-lymphocyte associated protein 4.	0.923
CD4	CXCL12	ENSCJAP00000043597	ENSCJAP00000030009	Ig-like domain-containing protein.	C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family.	0.682
CD4	CXCL13	ENSCJAP00000043597	ENSCJAP00000075621	Ig-like domain-containing protein.	C-X-C motif chemokine ligand 13.	0.666
CD4	FOXP3	ENSCJAP00000043597	ENSCJAP00000056781	Ig-like domain-containing protein.	Forkhead box P3.	0.949
CD4	FURIN	ENSCJAP00000043597	ENSCJAP00000017961	Ig-like domain-containing protein.	Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.	0.674
CD4	HAND2	ENSCJAP00000043597	ENSCJAP00000074938	Ig-like domain-containing protein.	Heart and neural crest derivatives expressed 2.	0.476
CD4	ICOS	ENSCJAP00000043597	ENSCJAP00000069147	Ig-like domain-containing protein.	Inducible T cell costimulator.	0.871
CD4	IFNG	ENSCJAP00000043597	ENSCJAP00000056963	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.960