(11 nodes) (2023) Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy. network (Callithrix jacchus)

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Your Input:
	RB1	Retinoblastoma-associated protein. (927 aa)
	CCNT1	Cyclin T1; Belongs to the cyclin family. (730 aa)
	EGFR	Receptor protein-tyrosine kinase. (1210 aa)
	BCL2	BCL2 apoptosis regulator. (240 aa)
	BRAF	Uncharacterized protein. (805 aa)
	CHEK2	Uncharacterized protein. (543 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1252 aa)
	CDK9	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (487 aa)
	ALB	Albumin. (608 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
	CCNT2	Cyclin-T2 isoform b; Belongs to the cyclin family. (729 aa)

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALB	BCL2	ENSCJAP00000025792	ENSCJAP00000066653	Albumin.	BCL2 apoptosis regulator.	0.644
ALB	EGFR	ENSCJAP00000025792	ENSCJAP00000074658	Albumin.	Receptor protein-tyrosine kinase.	0.597
ALB	MYC	ENSCJAP00000025792	ENSCJAP00000023101	Albumin.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.610
ALB	PTPRC	ENSCJAP00000025792	ENSCJAP00000045046	Albumin.	Protein tyrosine phosphatase receptor type C.	0.640
BCL2	ALB	ENSCJAP00000066653	ENSCJAP00000025792	BCL2 apoptosis regulator.	Albumin.	0.644
BCL2	BRAF	ENSCJAP00000066653	ENSCJAP00000060924	BCL2 apoptosis regulator.	Uncharacterized protein.	0.622
BCL2	EGFR	ENSCJAP00000066653	ENSCJAP00000074658	BCL2 apoptosis regulator.	Receptor protein-tyrosine kinase.	0.664
BCL2	MYC	ENSCJAP00000066653	ENSCJAP00000023101	BCL2 apoptosis regulator.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.828
BCL2	PTPRC	ENSCJAP00000066653	ENSCJAP00000045046	BCL2 apoptosis regulator.	Protein tyrosine phosphatase receptor type C.	0.420
BRAF	BCL2	ENSCJAP00000060924	ENSCJAP00000066653	Uncharacterized protein.	BCL2 apoptosis regulator.	0.622
BRAF	EGFR	ENSCJAP00000060924	ENSCJAP00000074658	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.576
BRAF	MYC	ENSCJAP00000060924	ENSCJAP00000023101	Uncharacterized protein.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.532
CCNT1	CCNT2	ENSCJAP00000075107	ENSCJAP00000021341	Cyclin T1; Belongs to the cyclin family.	Cyclin-T2 isoform b; Belongs to the cyclin family.	0.959
CCNT1	CDK9	ENSCJAP00000075107	ENSCJAP00000036928	Cyclin T1; Belongs to the cyclin family.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.999
CCNT1	MYC	ENSCJAP00000075107	ENSCJAP00000023101	Cyclin T1; Belongs to the cyclin family.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.818
CCNT1	RB1	ENSCJAP00000075107	ENSCJAP00000016760	Cyclin T1; Belongs to the cyclin family.	Retinoblastoma-associated protein.	0.465
CCNT2	CCNT1	ENSCJAP00000021341	ENSCJAP00000075107	Cyclin-T2 isoform b; Belongs to the cyclin family.	Cyclin T1; Belongs to the cyclin family.	0.959
CCNT2	CDK9	ENSCJAP00000021341	ENSCJAP00000036928	Cyclin-T2 isoform b; Belongs to the cyclin family.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.998
CCNT2	MYC	ENSCJAP00000021341	ENSCJAP00000023101	Cyclin-T2 isoform b; Belongs to the cyclin family.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).	0.568
CCNT2	RB1	ENSCJAP00000021341	ENSCJAP00000016760	Cyclin-T2 isoform b; Belongs to the cyclin family.	Retinoblastoma-associated protein.	0.485