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IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa) | ||||
PPARA | Peroxisome proliferator-activated receptor alpha. (468 aa) | ||||
TRIM28 | Tripartite motif containing 28. (835 aa) | ||||
STAT3 | Signal transducer and activator of transcription. (771 aa) | ||||
FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa) | ||||
LCK | Tyrosine-protein kinase. (539 aa) | ||||
KDM2A | Lysine demethylase 2A. (1163 aa) | ||||
WWTR1 | WW domain-containing protein. (400 aa) | ||||
CCR2 | C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (378 aa) | ||||
SMAD3 | Mothers against decapentaplegic homolog. (437 aa) | ||||
MTF1 | Metal regulatory transcription factor 1. (750 aa) | ||||
ATF4 | Activating transcription factor 4. (351 aa) | ||||
ITGAX | CD11c protein; Belongs to the integrin alpha chain family. (1161 aa) | ||||
UBE3A | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa) | ||||
ANXA2 | Annexin. (352 aa) | ||||
GPC3 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa) | ||||
SMAD2 | Mothers against decapentaplegic homolog. (494 aa) | ||||
LMNA | Uncharacterized protein; Belongs to the intermediate filament family. (677 aa) | ||||
SIRT3 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (413 aa) | ||||
FOXO3 | Forkhead box protein O3. (672 aa) | ||||
USP48 | Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1043 aa) | ||||
ABCB11 | ATP binding cassette subfamily B member 11. (1321 aa) | ||||
HADHB | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta. (444 aa) | ||||
GCK | Phosphotransferase. (478 aa) | ||||
HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1035 aa) | ||||
HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (990 aa) | ||||
PKM-2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa) | ||||
NRF1 | Nuclear respiratory factor 1. (522 aa) | ||||
LOC100385831 | Histone H3; Belongs to the histone H3 family. (135 aa) | ||||
SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa) | ||||
TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa) | ||||
BECN1 | Beclin-1. (450 aa) | ||||
HNF1A | HNF1 homeobox A. (638 aa) | ||||
AFP | Alpha fetoprotein. (609 aa) | ||||
SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa) | ||||
CROT | Peroxisomal carnitine O-octanoyltransferase isoform 2; Belongs to the carnitine/choline acetyltransferase family. (612 aa) | ||||
ACLY | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa) | ||||
SIRT6 | NAD-dependent protein deacetylase sirtuin-6 isoform 1. (355 aa) | ||||
IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) | ||||
MPO | Myeloperoxidase. (744 aa) | ||||
SIRT7 | NAD-dependent protein deacetylase sirtuin-7. (400 aa) | ||||
CLOCK | Circadian locomoter output cycles protein kaput. (850 aa) | ||||
PKM | Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa) | ||||
IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa) | ||||
LOC100397351 | Uncharacterized protein. (372 aa) | ||||
ACSL5 | Acyl-CoA synthetase long chain family member 5. (750 aa) | ||||
XBP1 | BZIP domain-containing protein. (371 aa) | ||||
TGFB1 | Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa) | ||||
ENDOG | Endonuclease. (299 aa) | ||||
LOC100398205 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
GCLC | Glutamate-cysteine ligase catalytic subunit. (643 aa) | ||||
SIRT1 | Sirtuin 1. (753 aa) | ||||
IL6 | Interleukin 6. (212 aa) | ||||
PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa) | ||||
PPARGC1A | PPARG coactivator 1 alpha. (802 aa) | ||||
LOC100394455 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
LOC100394573 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
ENSCJAP00000055722 | Pyruvate kinase; Belongs to the pyruvate kinase family. (507 aa) | ||||
ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) | ||||
LOC100413207 | Histone H3; Belongs to the histone H3 family. (135 aa) | ||||
LOC100414113 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
SCD | Acyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa) | ||||
ICAM1 | Intercellular adhesion molecule 1. (535 aa) | ||||
LOC100389168 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
ACACA | Acetyl-CoA carboxylase 1 isoform 1. (2383 aa) | ||||
SMAD7 | Mothers against decapentaplegic homolog. (426 aa) | ||||
ENSCJAP00000063804 | Histone H3; Belongs to the histone H3 family. (135 aa) | ||||
LOC100385283 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) | ||||
ENSCJAP00000065541 | Histone H3; Belongs to the histone H3 family. (136 aa) | ||||
HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1124 aa) | ||||
ENSCJAP00000066578 | Pyruvate kinase; Belongs to the pyruvate kinase family. (189 aa) | ||||
BCL2 | BCL2 apoptosis regulator. (240 aa) | ||||
TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa) | ||||
CIDEC | Cell death inducing DFFA like effector c. (263 aa) | ||||
TEAD1 | TEA domain transcription factor 1. (681 aa) | ||||
HDAC9 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1096 aa) | ||||
IGF2 | Insulin like growth factor 2. (348 aa) | ||||
PARP1 | Poly [ADP-ribose] polymerase. (1040 aa) | ||||
ENSCJAP00000074198 | Histone H3; Belongs to the histone H3 family. (124 aa) | ||||
SIRT5 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (313 aa) | ||||
NCOA2 | Nuclear receptor coactivator. (1480 aa) | ||||
RRAS2 | RAS related 2. (349 aa) | ||||
PCSK9 | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (690 aa) | ||||
CCL2 | C-C motif chemokine. (98 aa) | ||||
ENSCJAP00000077442 | Pyruvate kinase; Belongs to the pyruvate kinase family. (318 aa) | ||||
VGLL4 | Vestigial like family member 4. (496 aa) | ||||
LOC100386265 | Histone domain-containing protein. (136 aa) | ||||
NFE2L2 | Nuclear factor, erythroid 2 like 2. (622 aa) | ||||
HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa) |