STRINGSTRING
IHH IHH PPARA PPARA TRIM28 TRIM28 STAT3 STAT3 FZD4 FZD4 LCK LCK KDM2A KDM2A WWTR1 WWTR1 CCR2 CCR2 SMAD3 SMAD3 MTF1 MTF1 ATF4 ATF4 ITGAX ITGAX UBE3A UBE3A ANXA2 ANXA2 GPC3 GPC3 SMAD2 SMAD2 LMNA LMNA SIRT3 SIRT3 FOXO3 FOXO3 USP48 USP48 ABCB11 ABCB11 HADHB HADHB GCK GCK HDAC4 HDAC4 HDAC7 HDAC7 PKM-2 PKM-2 NRF1 NRF1 LOC100385831 LOC100385831 SMARCC2 SMARCC2 TGFB2 TGFB2 BECN1 BECN1 HNF1A HNF1A AFP AFP SIRT2 SIRT2 CROT CROT ACLY ACLY SIRT6 SIRT6 IL1B IL1B MPO MPO SIRT7 SIRT7 CLOCK CLOCK PKM PKM IL10 IL10 LOC100397351 LOC100397351 ACSL5 ACSL5 XBP1 XBP1 TGFB1 TGFB1 ENDOG ENDOG LOC100398205 LOC100398205 GCLC GCLC SIRT1 SIRT1 IL6 IL6 PKLR PKLR PPARGC1A PPARGC1A LOC100394455 LOC100394455 LOC100394573 LOC100394573 ENSCJAP00000055722 ENSCJAP00000055722 ELOVL6 ELOVL6 LOC100413207 LOC100413207 LOC100414113 LOC100414113 SCD SCD ICAM1 ICAM1 LOC100389168 LOC100389168 ACACA ACACA SMAD7 SMAD7 ENSCJAP00000063804 ENSCJAP00000063804 LOC100385283 LOC100385283 NR1H4 NR1H4 ENSCJAP00000065541 ENSCJAP00000065541 HDAC5 HDAC5 ENSCJAP00000066578 ENSCJAP00000066578 BCL2 BCL2 TP53 TP53 CIDEC CIDEC TEAD1 TEAD1 HDAC9 HDAC9 IGF2 IGF2 PARP1 PARP1 ENSCJAP00000074198 ENSCJAP00000074198 SIRT5 SIRT5 NCOA2 NCOA2 RRAS2 RRAS2 PCSK9 PCSK9 CCL2 CCL2 ENSCJAP00000077442 ENSCJAP00000077442 VGLL4 VGLL4 LOC100386265 LOC100386265 NFE2L2 NFE2L2 HDAC1 HDAC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (468 aa)
TRIM28Tripartite motif containing 28. (835 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
LCKTyrosine-protein kinase. (539 aa)
KDM2ALysine demethylase 2A. (1163 aa)
WWTR1WW domain-containing protein. (400 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (378 aa)
SMAD3Mothers against decapentaplegic homolog. (437 aa)
MTF1Metal regulatory transcription factor 1. (750 aa)
ATF4Activating transcription factor 4. (351 aa)
ITGAXCD11c protein; Belongs to the integrin alpha chain family. (1161 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (876 aa)
ANXA2Annexin. (352 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
SMAD2Mothers against decapentaplegic homolog. (494 aa)
LMNAUncharacterized protein; Belongs to the intermediate filament family. (677 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (413 aa)
FOXO3Forkhead box protein O3. (672 aa)
USP48Ubiquitin specific peptidase 48; Belongs to the peptidase C19 family. (1043 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
HADHBHydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta. (444 aa)
GCKPhosphotransferase. (478 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1035 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (990 aa)
PKM-2Pyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
NRF1Nuclear respiratory factor 1. (522 aa)
LOC100385831Histone H3; Belongs to the histone H3 family. (135 aa)
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2. (1245 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BECN1Beclin-1. (450 aa)
HNF1AHNF1 homeobox A. (638 aa)
AFPAlpha fetoprotein. (609 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
CROTPeroxisomal carnitine O-octanoyltransferase isoform 2; Belongs to the carnitine/choline acetyltransferase family. (612 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6 isoform 1. (355 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
MPOMyeloperoxidase. (744 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (400 aa)
CLOCKCircadian locomoter output cycles protein kaput. (850 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
LOC100397351Uncharacterized protein. (372 aa)
ACSL5Acyl-CoA synthetase long chain family member 5. (750 aa)
XBP1BZIP domain-containing protein. (371 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENDOGEndonuclease. (299 aa)
LOC100398205Histone H3; Belongs to the histone H3 family. (136 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (643 aa)
SIRT1Sirtuin 1. (753 aa)
IL6Interleukin 6. (212 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
PPARGC1APPARG coactivator 1 alpha. (802 aa)
LOC100394455Histone H3; Belongs to the histone H3 family. (136 aa)
LOC100394573Histone H3; Belongs to the histone H3 family. (136 aa)
ENSCJAP00000055722Pyruvate kinase; Belongs to the pyruvate kinase family. (507 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
LOC100413207Histone H3; Belongs to the histone H3 family. (135 aa)
LOC100414113Histone H3; Belongs to the histone H3 family. (136 aa)
SCDAcyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
ICAM1Intercellular adhesion molecule 1. (535 aa)
LOC100389168Histone H3; Belongs to the histone H3 family. (136 aa)
ACACAAcetyl-CoA carboxylase 1 isoform 1. (2383 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ENSCJAP00000063804Histone H3; Belongs to the histone H3 family. (135 aa)
LOC100385283Histone H3; Belongs to the histone H3 family. (136 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
ENSCJAP00000065541Histone H3; Belongs to the histone H3 family. (136 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1124 aa)
ENSCJAP00000066578Pyruvate kinase; Belongs to the pyruvate kinase family. (189 aa)
BCL2BCL2 apoptosis regulator. (240 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (396 aa)
CIDECCell death inducing DFFA like effector c. (263 aa)
TEAD1TEA domain transcription factor 1. (681 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1096 aa)
IGF2Insulin like growth factor 2. (348 aa)
PARP1Poly [ADP-ribose] polymerase. (1040 aa)
ENSCJAP00000074198Histone H3; Belongs to the histone H3 family. (124 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (313 aa)
NCOA2Nuclear receptor coactivator. (1480 aa)
RRAS2RAS related 2. (349 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] (690 aa)
CCL2C-C motif chemokine. (98 aa)
ENSCJAP00000077442Pyruvate kinase; Belongs to the pyruvate kinase family. (318 aa)
VGLL4Vestigial like family member 4. (496 aa)
LOC100386265Histone domain-containing protein. (136 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (622 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (540 aa)
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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